An update on pharmacological treatment of erectile dysfunction with phosphodiesterase type 5 inhibitors.

abstract：INTRODUCTION:Chronic hepatitis C infection is a global disease with 160 million people infected worldwide. Until recently, therapy was characterized by long duration, suboptimal success rates and significant adverse drug reactions. The development of direct-acting antivirals initiated a dramatic change in the treatment...

journal_title：Expert opinion on pharmacotherapy

authors： Stirnimann G

更新日期：2014-12-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a frequent disease leading to functional impairment and socioeconomic burden. Anti-TNF-alpha therapy has brought new perspectives in this condition. Two agents are currently used in the treatment of AS and spondyloarthropathies - infliximab (a chimeric monoclonal antibody) and etanercept...

journal_title：Expert opinion on pharmacotherapy

authors： Wendling D,Toussirot E

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Patients with rheumatoid arthritis (RA) have an increased risk of atherosclerotic cardiovascular disease which cannot be explained by traditional cardiovascular risk factors alone. Atherosclerosis is considered an inflammatory condition and inflammation experienced in RA may contribute to accelerated atheros...

journal_title：Expert opinion on pharmacotherapy

authors： Avouac J,Allanore Y

更新日期：2008-05-01 00:00:00

abstract：:Antiplatelet therapy is the cornerstone of treatment for patients who present with acute coronary syndrome (ACS) or undergo percutaneous coronary intervention (PCI). Clopidogrel, in combination with aspirin, is associated with improvement in long-term clinical outcomes in these patients and is currently the antiplatel...

journal_title：Expert opinion on pharmacotherapy

authors： Angiolillo DJ,Suryadevara S,Capranzano P,Bass TA

更新日期：2008-11-01 00:00:00

abstract：:Osteoporosis is a severe condition, associated with significant disability as a result of fragility fractures and increased mortality. Oral bisphosphonates effectively reduce the risk of osteoporotic fracture and are generally well tolerated. Unfortunately, patient outcomes are often compromised by suboptimal therapeu...

journal_title：Expert opinion on pharmacotherapy

authors： Reginster JY

更新日期：2005-10-01 00:00:00

abstract：INTRODUCTION:Breast cancer is a common, life-threatening disease among women. Contemporary hormonal therapy with third-generation aromatase inhibitors for estrogen-receptor-positive breast cancers in postmenopausal women is still facing the challenge of interpatient variability in therapeutic response and intensity of ...

journal_title：Expert opinion on pharmacotherapy

authors： Turkistani A,Marsh S

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:The epidermal growth factor receptor (EGFR) is mutated in 15% of adenocarcinomas of the lung. In addition, the anaplastic lymphoma kinase (ALK) is altered in 8% of adenocarcinomas of the lung. Treatment of EGFR mutant and ALK translocation-positive tumors in NSCLC with tyrosine kinase inhibitors (TKI) resu...

journal_title：Expert opinion on pharmacotherapy

authors： Somasundaram A,Socinski MA,Burns TF

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:With growing knowledge of the molecular pathway of carcinogenesis, targeted therapies have become the 'blue ocean' of cancer treatment. sorafenib is an oral multikinase inhibitor that targets Raf/mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase (ERK) (Raf/MEK/ERK) and several ty...

journal_title：Expert opinion on pharmacotherapy

authors： Woo HY,Heo J

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Hodgkin lymphoma (HL) is a lymphoid malignancy with an incidence of 2 - 3/100,000/year. Young adults are most often affected. Due to the development of highly active multi-agent chemotherapy protocols and the optimization of radiotherapy (RT) fields and doses, HL has become one of the malignancies with the...

journal_title：Expert opinion on pharmacotherapy

authors： Eichenauer DA,Böll B,Diehl V

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:Patients with advanced pancreatic cancer (APC) refractory to first-line therapy have a dismal prognosis and limited therapeutic options, with only one option consisting of nanoliposomal irinotecan in combination with fluorouracil and folinic acid which was approved by FDA based upon results of the phase II...

journal_title：Expert opinion on pharmacotherapy

authors： Passero FC Jr,Saif MW

更新日期：2017-10-01 00:00:00

abstract：:Although panic disorder usually emerges in early to middle adulthood, adults with panic disorder often retrospectively report that their panic symptoms began in childhood or early adolescence. The majority of these juvenile cases are being misdiagnosed, and/or do not come to clinical attention. Awareness of early-onse...

journal_title：Expert opinion on pharmacotherapy

authors： Masi G,Pari C,Millepiedi S

更新日期：2006-04-01 00:00:00

abstract：:The increasing burden of cardiovascular diseases in developed, as well as developing countries, underscores the need for the more widespread and appropriate use of aspirin in secondary prevention of occlusive vascular events during acute evolving myocardial infarction (MI) and in primary prevention. Aspirin should be ...

journal_title：Expert opinion on pharmacotherapy

authors： Williams A,Hennekens CH

更新日期：2004-01-01 00:00:00

abstract：:Migraine is a multifactorial and disabling syndrome often in comorbidity with psychiatric illnesses. Triptans are the first-line treatment in acute attacks and the most effective drugs in various types of migraine. Sumatriptan was the first medication of this group. Thanks to multiple types of formulations that greatl...

journal_title：Expert opinion on pharmacotherapy

authors： Napoletano F,Lionetto L,Martelletti P

更新日期：2014-02-01 00:00:00

abstract：:The prevalence of obesity has noticeably increased worldwide. The clinician is now frequently facing the challenge of managing patients with concomitant chronic obstructive pulmonary disease (COPD) or asthma and obesity. Obesity is often associated with a poorer control of these chronic respiratory diseases and the op...

journal_title：Expert opinion on pharmacotherapy

authors： Lessard A,Maltais F,Boulet LP

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:When estimating the cost-effectiveness or budget impact of chronic obstructive pulmonary disease (COPD) medication, it is common practice to use trial data for clinical inputs. However, such inputs do not always reflect the real-world situation. Previous reviews recognized the need for taking real-world da...

journal_title：Expert opinion on pharmacotherapy

authors： Fens T,Zhou G,Postma MJ,van Puijenbroek EP,van Boven JFM

更新日期：2021-01-13 00:00:00

abstract：:Numerous pregnant women suffer from asthma and the use of asthma medications during pregnancy may be a necessity. Although some information is known about the effects of asthma medications during pregnancy, there is still a significant amount of information to learn and particular attention is required when prescribin...

journal_title：Expert opinion on pharmacotherapy

authors： Demoly P,Piette V,Daures JP

更新日期：2003-07-01 00:00:00

abstract：:Vaginal ring delivery systems are a highly promising approach to hormone replacement therapy (HRT). The vagina is an excellent route for steroid absorption. Menopausal vaginal rings can be designed to allow very low dose local delivery of oestrogen to the vagina for the large percentage of postmenopausal women experie...

journal_title：Expert opinion on pharmacotherapy

authors： Dezarnaulds G,Fraser IS

更新日期：2003-02-01 00:00:00

abstract：:Efavirenz is a non-nucleoside reverse transcriptase inhibitor that in most treatment guidelines is recommended to be taken combined with two nucleoside analogue reverse transcriptase inhibitors, as a preferred first-line regimen for the treatment of HIV-1 infection. The antiretroviral efficacy of efavirenz-based combi...

journal_title：Expert opinion on pharmacotherapy

authors： Vrouenraets SM,Wit FW,van Tongeren J,Lange JM

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To explore the treatment response, tolerability and safety of once-monthly paliperidone palmitate (PP1M) in non-acute patients switched from oral antipsychotics, stratified by time since diagnosis as recently diagnosed (≤3 years) or chronic patients (>3 years). RESEARCH DESIGN AND METHODS:Post hoc analysis o...

journal_title：Expert opinion on pharmacotherapy

authors： Hargarter L,Bergmans P,Cherubin P,Keim S,Conca A,Serrano-Blanco A,Bitter I,Bilanakis N,Schreiner A

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:This comparison of PRAsugrel and clopidogrel in Japanese patients with ischemic STROke (PRASTRO)-I trial investigates the noninferiority of prasugrel to clopidogrel sulfate in the prevention of recurrence of primary events (ischemic stroke, myocardial infarction, and death from other vascular causes), and th...

journal_title：Expert opinion on pharmacotherapy

authors： Nagao T,Toyoda K,Kitagawa K,Kitazono T,Yamagami H,Uchiyama S,Tanahashi N,Matsumoto M,Minematsu K,Nagata I,Nishikawa M,Nanto S,Abe K,Ikeda Y,Ogawa A

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:In non-exacerbation chronic obstructive pulmonary disease (COPD) with mild lung function impairment, single bronchodilator therapy might be as effective as combined inhaled corticosteroid/bronchodilator therapy, whereas the risk of pneumonia associated with the latter would be practically absent. AREAS CO...

journal_title：Expert opinion on pharmacotherapy

authors： Ruxandra U,Antoniu SA,Mihaltan F,Boisteanu D

更新日期：2015-01-01 00:00:00

abstract：:Following Huggins' original observation of the dependence of the prostate on androgens, testosterone suppression by either orchiectomy or oestrogen compounds (e.g., diethylstilbesterol [DES]) became the standard palliative treatment for advanced prostate cancer. Early studies showed testosterone suppression improved s...

journal_title：Expert opinion on pharmacotherapy

authors： Perez-Marrero R,Tyler RC

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:Pharmacological treatment plays a major role in the management of advanced, persistent or recurrent uterine leiomyosarcoma (LMS), whereas its usefulness in the adjuvant setting is still debated. A thorough literature search was undertaken using the Pubmed databases. Systematic reviews and controlled trials...

journal_title：Expert opinion on pharmacotherapy

authors： Gadducci A,Guerrieri ME

更新日期：2015-02-01 00:00:00

abstract：:There is accumulating evidence that tumour necrosis factor (TNF) plays a major role in the pathogenesis of rheumatoid arthritis (RA). Recent biotechnological advances have allowed for the development of agents that directly target TNF, a pro-inflammatory cytokine. In the last 2 years, the US FDA and the EU's Commissio...

journal_title：Expert opinion on pharmacotherapy

authors： Mikuls TR,Moreland LW

更新日期：2001-01-01 00:00:00

abstract：:This is a review of the literature comparing the efficacy and safety of drug-eluting stents (DES) versus bare-metal stents (BMS) in patients with acute myocardial infarction (MI). The present article reviews whether DES are beneficial in the setting of primary percutaneous coronary intervention (PCI), and this has bee...

journal_title：Expert opinion on pharmacotherapy

authors： Yeter E,Kurt M,Silay Y,Anderson HV,Denktas AE

更新日期：2009-01-01 00:00:00

abstract：:Introduction: Psoriatic arthritis (PsA) is a chronic inflammatory condition that is associated with progressive joint destruction and reduced quality of life. Despite the common use of disease-modifying anti-rheumatic drugs (DMARDs) in PsA, their influence has been investigated in a number of studies with conflicting ...

journal_title：Expert opinion on pharmacotherapy

authors： Abdulrahim H,Sharlala H,Adebajo AO

更新日期：2019-11-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Diabetes mellitus is the most common endocrine disease in childhood. The global incidence of diabetes emphasizes the health, social and financial magnitude of this disease and the importance of optimizing disease management and prevention. AREAS COVERED IN THIS REVIEW:This article reviews the t...

journal_title：Expert opinion on pharmacotherapy

authors： Verrotti A,Chiuri RM,Blasetti A,Mohn A,Chiarelli F

更新日期：2010-10-01 00:00:00

abstract：:The International Continence Society has defined overactive bladder (OAB) as urinary urgency, with or without urge urinary incontinence, usually with urinary frequency and nocturia. Approximately 17% of men and women in the US report OAB symptoms, which can affect quality of life. Trospium chloride, which has recently...

journal_title：Expert opinion on pharmacotherapy

authors： Zinner NR

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:In a previous multicentre study including 129 HIV-infected children, non-adherence to antiretroviral therapy was detected in 16% of patients and was mainly related to psychosocial rather than clinical or demographic features. The aim of this study was to explore the evolving pattern of adherence and its deter...

journal_title：Expert opinion on pharmacotherapy

authors： Giannattasio A,Albano F,Giacomet V,Guarino A

更新日期：2009-12-01 00:00:00

abstract：:Itraconazole is a broad spectrum triazole antifungal agent. It has favourable pharmacodynamic and pharmacokinetic profiles and is available as both oral and i.v. formulations. Over the last two decades, clinical and animal infection studies have demonstrated the efficacy of itraconazole in a wide range of superficial ...

journal_title：Expert opinion on pharmacotherapy

authors： Piérard GE,Arrese JE,Piérard-Franchimont C

更新日期：2000-01-01 00:00:00