Abstract:
:Reduced intensity conditioning followed by allogeneic SCT (RIC-SCT) has recently emerged as promising new salvage option for children suffering from Langerhans cell histiocytosis (LCH) with risk organ involvement and failure to conventional therapy. We report on the posttransplant course of female toddler with high-risk LCH, who achieved complete remission after RIC-SCT, despite a posttransplant chimerism constellation, in which only the T-cell subset proved to be of donor origin in the long-term. We therefore suggest that allogeneic T-cells have played a crucial role in controlling disease activity in this patient and may exert the major curative effect after RIC-SCT for LCH.
journal_name
Haematologicajournal_title
Haematologicaauthors
Steiner M,Matthes-Martin S,Attarbaschi A,Lawitschka A,Minkov M,Mittheisz E,Fritsch G,Lion T,Zoubek A,Gadner Hdoi
10.3324/haematol.10993subject
Has Abstractpub_date
2007-01-01 00:00:00pages
e3-4issue
1eissn
0390-6078issn
1592-8721journal_volume
92pub_type
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