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From hyperinsulinaemic hypoglycaemia to ketotic hypoglycaemia: the range of glucose abnormalities in patients born with intrauterine growth retardation.

Abstract：

INTRODUCTION:Newborns with intrauterine growth retardation (IUGR) have multiple risk factors for developing hypoglycaemia. Hyperinsulinism, both transient and prolonged, is one of the major risk factors responsible for the hypoglycaemia observed in some newborns with IUGR. Once the child has progressed beyond the infancy period, the most common cause of hypoglycaemia is ketotic hypoglycaemia. We report our observations of ketotic hypoglycaemia in six children who were born with IUGR and developed hyperinsulinaemic hypoglycaemia (HH) that required treatment with diazoxide and chlorothiazide. RESULTS:In one of these children the ketotic hypoglycaemia was found to be due to growth hormone deficiency; in the remaining five patients, however, no cause for the hypoglycaemia could be found, despite extensive investigations. These observations suggest that ketotic hypoglycaemia may be more common in children with a history of IUGR. Further studies are required to understand why some newborns with IUGR and HH have an increased risk of ketotic hypoglycaemia in childhood. CONCLUSION:Newborns with a history of IUGR and HH have an increased risk of developing ketotic hypoglycaemia in the childhood period.

journal_name

Eur J Pediatr

journal_title

European journal of pediatrics

authors

Kochar IS,Hussain K

doi

10.1007/s00431-006-0371-1

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

1003-7

issue

10

eissn

0340-6199

issn

1432-1076

journal_volume

166

pub_type

杂志文章

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