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A case of Muir-Torre syndrome associated with mucinous hepatic cholangiocarcinoma and a novel germline mutation of the MSH2 gene.

Abstract：

:Muir-Torre syndrome (MTS) is a rare cancer-predisposing syndrome that is autosomal dominantly inherited and characterized by the development of sebaceous skin lesions (adenomas, epitheliomas, basaliomas and carcinomas). These lesions are typically associated with tumors that belong to the spectrum of hereditary nonpolyposis colorectal cancer (HNPCC) (i.e., tumors of the colorectum, endometrium, stomach or ovary). Biliary malignancy in association with MTS has only rarely been reported. We report a case of Muir-Torre syndrome associated with intrahepatic cholangiocarcinoma, a location not previously described, and associated with a novel missense mutation of the MSH2 gene (c.2026T > C), predicted to disrupt the function of the gene.

journal_name

Fam Cancer

journal_title

Familial cancer

authors

Vernez M,Hutter P,Monnerat C,Halkic N,Gugerli O,Bouzourene H

doi

10.1007/s10689-006-9105-9

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

141-5

issue

1

eissn

1389-9600

issn

1573-7292

journal_volume

6

pub_type

杂志文章

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