Abstract:
AIM:To test if treatment with GnRH analogue, which leads to a significant reduction in myoma volume, changes expression of leptin genes and gene coding leptin receptor isoforms in uterine myomas and in the surrounding unaltered myometrium. METHODS:Using RT-PCR, expression of leptin genes and leptin receptor genes was studied in myomas and in the surrounding myometrium in women with uterine myomas, untreated or treated with GnRH analogue. In the randomly selected cases presence of leptin protein and of leptin receptor proteins was examined also by Western blotting. RESULTS:Expression of leptin genes was demonstrated both in myomas and in the surrounding myometrium, and a similar pattern of expression was found for leptin receptor isoforms. The results of RT-PCR were confirmed by Western blotting, which documented the identical distribution of leptin proteins and leptin receptor proteins in studied tissues. Treatment with GnRH analogue had no effect on the expression pattern of studied genes. CONCLUSION:The results of the present study on the administration of GnRH analogue to females with myomas suggest that no direct or immediate inter-relationship exists between expression of leptin genes in uterine myomas on one hand and estrogen, progesterone and leptin levels in the blood on the other. Expression seems to be of a more durable nature but factors that induce such expression remain unknown.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
Markowska A,Rucinski M,Drews K,Malendowicz LKsubject
Has Abstractpub_date
2006-01-01 00:00:00pages
379-84issue
4eissn
0392-2936issn
2709-0086journal_volume
27pub_type
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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