Transsphenoidal microsurgery: past, present and future.

abstract：:Early diagnosis of lung cancer is important due to high mortality in late stages of the disease. An ideal approach for population screening could be the breath analysis, due to its non-invasiveness, simplicity and cheapness. Using sensitive methods of analysis like gas chromatography/mass spectrometry in exhaled air o...

journal_title：Expert review of anticancer therapy

authors： Taivans I,Bukovskis M,Strazda G,Jurka N

更新日期：2013-12-13 00:00:00

abstract：:The incidence of thyroid cancer is increasing by 4% per year. Thyroid cancer has become the eighth most common malignancy diagnosed in women. Papillary cancer accounts for 80% of all thyroid cancer. The management of papillary thyroid cancer is challenging, primarily because there have been no prospective randomized t...

journal_title：Expert review of anticancer therapy

authors： Rosenbaum MA,McHenry CR

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:Serous tubal intraepithelial carcinoma (STIC) is most likely precursor lesion of the most part of high-grade serous pelvis carcinomas, carcinosarcoma and undifferentiated carcinoma with incidence of 0.6% to 7% in BRCA carriers or women with strong family history of breast or ovarian carcinoma. STIC is a pa...

journal_title：Expert review of anticancer therapy

authors： Weinberger V,Bednarikova M,Cibula D,Zikan M

更新日期：2016-12-01 00:00:00

abstract：:Adrenocortical carcinoma is a rare disorder with a prevalence of one case per 1.7 million people and a generally poor prognosis. It accounts for 0.02% of all cancer cases and 0.2% of cancer deaths. Within the past three decades, accurate diagnosis, precise radiologic localization, satisfactory preoperative medical man...

journal_title：Expert review of anticancer therapy

authors： Haleblian GE,Wilson C,Haddad D,Albala DM

更新日期：2007-09-01 00:00:00

abstract：:Despite being a common cancer worldwide, management of transitional cell carcinoma of the bladder currently relies primarily on clinical staging and histopathologic parameters. Assaying alterations in molecular pathways can contribute valuable information that can accurately predict outcome and chemotherapeutic respon...

journal_title：Expert review of anticancer therapy

authors： Bartsch G,Mitra AP,Cote RJ

更新日期：2010-12-01 00:00:00

abstract：:While early-stage endometrial cancer is highly curable after hysterectomy for the majority of patients afflicted with this disease, recurrent and metastatic endometrial cancer continues to pose a significant challenge. The median survival of women with advanced or recurrent uterine cancer on most recent clinical trial...

journal_title：Expert review of anticancer therapy

authors： Dellinger TH,Monk BJ

更新日期：2009-07-01 00:00:00

abstract：:With the introduction of orally-active, potent and selective third-generation aromatase inhibitors and inactivators--anastrozole, letrozole and exemestane--approaches to the treatment of advanced breast cancer are undergoing re-evaluation. In advanced breast cancer, aromatase inhibitors and inactivators are likely to ...

journal_title：Expert review of anticancer therapy

authors： Dixon JM

更新日期：2002-06-01 00:00:00

abstract：:The year 2006 will mark a turning point in the daily management of patients with metastatic renal cell carcinoma. The impact of immunotherapy with interferon-alpha or interleukin-2 has been shown to be restricted to a minority of patients. The growing understanding of molecular mechanisms involved in the pathogenesis ...

journal_title：Expert review of anticancer therapy

authors： Pouessel D,Culine S

更新日期：2006-12-01 00:00:00

abstract：:As with many human malignancies, pancreatic cancer is a complex genetic disorder. Several thousand disease-associated alterations on the DNA, mRNA, miRNA and protein levels have been reported to date. Some of these alterations, including a number of gatekeeper mutations, which are of pre-eminent importance for the ons...

journal_title：Expert review of anticancer therapy

authors： Buchholz M,Gress TM

更新日期：2009-10-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common primary brain malignancy. The current standard of therapy consists of surgical resection followed by concurrent chemoradiotherapy with temozolomide. Despite steady advances in all therapeutic modalities, clinical improvements have been slow and the prognosis remains poo...

journal_title：Expert review of anticancer therapy

authors： Wardak Z,Choe KS

更新日期：2013-11-01 00:00:00

abstract：:The desmoid tumors (DTs) are unusual soft-tissue tumors that have a propensity for aggressive local growth and may develop during, or soon after pregnancy. Pregnancy-associated DTs are uncommon and optimal management of this tumor has yet to be defined. Currently, controversy centers on the timing of surgical resectio...

journal_title：Expert review of anticancer therapy

authors： Johner A,Tiwari P,Zetler P,Wiseman SM

更新日期：2009-11-01 00:00:00

abstract：INTRODUCTION:The therapeutic armamentarium for advanced soft tissue sarcoma (STS) has increased over the last few years. Doxorubicin monotherapy or in combination is now the established first line treatment. Beyond first line treatment, no standard therapy has been established. Novel drugs have reached the late-clinica...

journal_title：Expert review of anticancer therapy

authors： Skafida E,Kokkali S,Nikolaou M,Digklia A

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:In the majority of cases, multiple myeloma is a disease occurring in elderly patients. In the last decades, a major improvement in myeloma patients' outcome has been achieved with the introduction of several new drugs. However, this positive outcome was less likely to occur in elderly patients. Areas cover...

journal_title：Expert review of anticancer therapy

authors： Salvini M,D'Agostino M,Bonello F,Boccadoro M,Bringhen S

更新日期：2018-09-01 00:00:00

abstract：:Until now, no effective systemic treatment options have been available for patients with unresectable advanced hepatocellular carcinoma (HCC). In the Sorafenib Hepatocellular Carcinoma Assessment Randomized Protocol (SHARP), patients with unresectable advanced HCC with Child-Pugh liver function class A and who had not...

journal_title：Expert review of anticancer therapy

authors： Rimassa L,Santoro A

更新日期：2009-06-01 00:00:00

abstract：:Raltitrexed is a cytotoxic agent, rationally designed to inhibit a specific molecular target, thymidylate synthase. In contrast to other agents, raltitrexed inhibits thymidylate synthase directly and specifically in a mixed, noncompetitive manner, which may lead to an improved toxicity profile. After promising Phase I...

journal_title：Expert review of anticancer therapy

authors： Surmont VF,van Meerbeeck JP

更新日期：2011-10-01 00:00:00

abstract：:Regional lymph node irradiation is usually indicated in patients with positive node breast cancer. However, there are some controversies regarding the clinical benefits of adding regional nodal irradiation to whole-breast or thoracic-wall irradiation after breast surgery especially for patients with 1 to 3 positive ax...

journal_title：Expert review of anticancer therapy

authors： Marta GN,de Moraes FY

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:: Renal cell carcinoma is no longer considered a monolithic disease, but a group of different entities exhibiting unique molecular alterations requiring a tailored systemic approach. One of the remaining challenges is the identification of the best candidate for a particular therapeutic regimen. AREAS COV...

journal_title：Expert review of anticancer therapy

authors： González J,Gaynor JJ,Ciancio G

更新日期：2021-01-29 00:00:00

abstract：:Introduction: The microbiota is recognized for its impact on both human health and disease. The human microbiota is made up of trillions of cells, including bacteria, viruses, and fungi. The largest population of microbes reside in the gut, prompting research for better understanding of the impact of gastrointestinal ...

journal_title：Expert review of anticancer therapy

authors： Garajová I,Balsano R,Wang H,Leonardi F,Giovannetti E,Deng D,Peters GJ

更新日期：2020-12-08 00:00:00

abstract：:The role of neoadjuvant chemotherapy in muscle-invasive bladder cancer has been clarified by recent randomized studies and meta-analyses, which all showed that cisplatin-based, combination chemotherapy offers a significant survival advantage. Preoperative chemotherapy results in downstaging in a significant percentage...

journal_title：Expert review of anticancer therapy

authors： Bamias A,Dimopoulos MA

更新日期：2005-12-01 00:00:00

abstract：INTRODUCTION:In breast cancer, estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) are essential biomarkers to predict response to endocrine and anti-HER2 therapies, respectively. In metastatic breast cancer, the use of these receptors and targeted therapies present additional challenges: tempora...

journal_title：Expert review of anticancer therapy

authors： Martínez-Pérez C,Turnbull AK,Dixon JM

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:The success of the immune checkpoint inhibitors in melanoma has reinvigorated the field of immunotherapy. Immune checkpoint inhibitors are now the standard of care in multiple cancer types including lung cancer, head and neck cancer, urothelial cancer and renal cell cancer. The field of immunotherapy is cu...

journal_title：Expert review of anticancer therapy

authors： O'reilly A,Larkin J

更新日期：2017-07-01 00:00:00

abstract：:Total mesorectal excision has been established as a standard surgical procedure for rectal cancer. MRI is now routinely used for preoperative staging of rectal cancer and provides accurate assessment of the tumor relative to the circumferential margin, that is, the mesorectal fascia. This identifies patients at risk o...

journal_title：Expert review of anticancer therapy

authors： Jhaveri KS,Sadaf A

更新日期：2009-04-01 00:00:00

abstract：:This article reviews the current status of robotic-assisted radical prostatectomy (RARP) with outcome analysis. The published English literature (PubMed) database was searched extensively for major publications and large series on RARP. The search was carried out over the preceding 3-year period. Selected series were ...

journal_title：Expert review of anticancer therapy

authors： Singh I,Hemal AK

更新日期：2010-05-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients with metastases limited in site and number, termed oligometastases, may represent a unique subpopulation of advanced NSCLC with improved prognosis. The optimal management of these patients remains unclear with the treatment approach currently undergoing a paradigm shift. The...

journal_title：Expert review of anticancer therapy

authors： Bergsma DP,Salama JK,Singh DP,Chmura SJ,Milano MT

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:About 50% of all patients with advanced testicular cancer demonstrate residual retroperitoneal or extraretroperitoneal masses. About two thirds of the masses harbour necrosis/fibrosis only whereas as about 10% and 40% harbour vital cancer or teratoma. Appropriate therapy will result in a high cure rate if ...

journal_title：Expert review of anticancer therapy

authors： Heidenreich A,Paffenholz P,Nestler T,Pfister D

更新日期：2019-04-01 00:00:00

abstract：:As diagnostic and therapeutic options increase, strategies for the treatment of non-small-cell lung cancer (NSCLC) are becoming more tailored for specific patient subpopulations and individual patients. The introduction of therapy targeted against the EGF receptor (EGFR) pathway has provided new treatment options for ...

journal_title：Expert review of anticancer therapy

authors： Batus M,Fidler MJ,Bonomi PD

更新日期：2010-10-01 00:00:00

abstract：:For most sporadic cancers, genetic susceptibility results from the additive effect of multiple genetic variants, each of which contributes a modest risk individually. The study of genetic single nucleotide polymorphisms (SNPs) may help explain the differences in individual cancer susceptibility and may assist in ident...

journal_title：Expert review of anticancer therapy

authors： Meyer LA,Westin SN,Lu KH,Milam MR

更新日期：2008-07-01 00:00:00

abstract：:Androgen receptor (AR) signaling is necessary for the development of prostate cancer. Androgen-deprivation therapy (ADT) for prostate cancer was described over 50 years ago and ADT remains the mainstay of systemic therapy. AR signaling remains intact as the disease evolves to castration-resistant prostate cancer (CRPC...

journal_title：Expert review of anticancer therapy

authors： Taplin ME

更新日期：2008-09-01 00:00:00

abstract：:Nonseminomatous germ cell tumors of the testicle are highly treatable and curable. The evolution of cancer control for this disease has demonstrated an effective integration of medical and surgical approaches over the last 30 years. Current emphasis in the therapy of nonseminomatous germ cell tumors focuses on minimiz...

journal_title：Expert review of anticancer therapy

authors： Yoon GH,Stein JP,Skinner DG

更新日期：2005-02-01 00:00:00

abstract：:Diffuse brain stem glioma is the most devastating of pediatric malignancies. Virtually all children with this disease die within 1-2 years of diagnosis. After three decades of exhaustive research, the key to controlling this malignancy still eludes us. Attempts to improve survival using radiation, chemotherapy and bio...

journal_title：Expert review of anticancer therapy

authors： Korones DN

更新日期：2007-05-01 00:00:00