Neoadjuvant chemotherapy in invasive bladder cancer.

Abstract:

:The role of neoadjuvant chemotherapy in muscle-invasive bladder cancer has been clarified by recent randomized studies and meta-analyses, which all showed that cisplatin-based, combination chemotherapy offers a significant survival advantage. Preoperative chemotherapy results in downstaging in a significant percentage of patients, which is an independent factor of favorable prognosis. Nevertheless, the optimal sequence of perioperative chemotherapy remains undefined. The authors examine the results of large Phase II and randomized studies as well as the role of neoadjuvant chemotherapy in the context of bladder preservation strategies. Finally, issues of improving therapeutic efficacy and directing clinical research are discussed.

authors

Bamias A,Dimopoulos MA

doi

10.1586/14737140.5.6.993

keywords:

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

993-1000

issue

6

eissn

1473-7140

issn

1744-8328

journal_volume

5

pub_type

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