Abstract:
:In order to develop a sensitive audiometric protocol for identifying ototoxicity in children, a retrospective study of 16 children treated with cisplatin and/or carboplatin was performed. Audiometric testing was done by means of pure-tone threshold audiometry (PTA), high-frequency audiometry (HFA), and distortion product otoacoustic emissions (DPOAEs). Cisplatin caused a sensorineural high-frequency hearing loss in the study group compared to the controls (p < 0.01). Sixty-six percent of the cisplatin patients had a grade 2 or 3 ototoxicity. However, ototoxicity was not found in the patients treated with carboplatin. An excellent correlation was found between DPOAE levels and results obtained by audiometry (r = 0.82). Patients exposed to cisplatin are at significant risk for the development of drug-induced sensorineural hearing loss. Because of the several advantages of DPOAEs (noninvasive, objective, rapid, easy to use, sensitive) this method should be added in the audiological follow-up in infants and toddlers.
journal_name
Int J Audioljournal_title
International journal of audiologyauthors
Dhooge I,Dhooge C,Geukens S,De Clerck B,De Vel E,Vinck BMdoi
10.1080/14992020600582117subject
Has Abstractpub_date
2006-06-01 00:00:00pages
337-43issue
6eissn
1499-2027issn
1708-8186pii
J229V287Q2T35241journal_volume
45pub_type
杂志文章abstract::Audiometric measurements through a hearing aid ('in-situ') may facilitate provision of hearing services where these are limited. This study investigated the validity and reliability of in-situ air conduction hearing thresholds measured with closed and open domes relative to thresholds measured with insert earphones, a...
journal_title:International journal of audiology
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abstract::The purpose of this study was to examine the current status of newborn/infant hearing screening programs in public sector hospitals in South Africa by means of a descriptive survey. Data was gathered using a self-administered postal questionnaire, which included questions on screening resources and protocols, follow-u...
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journal_title:International journal of audiology
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journal_title:International journal of audiology
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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journal_title:International journal of audiology
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journal_title:International journal of audiology
pub_type: 杂志文章,随机对照试验
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更新日期:2016-07-01 00:00:00
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journal_title:International journal of audiology
pub_type: 杂志文章,多中心研究
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更新日期:2014-03-01 00:00:00
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更新日期:2009-01-01 00:00:00
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journal_title:International journal of audiology
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更新日期:2005-05-01 00:00:00
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journal_title:International journal of audiology
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journal_title:International journal of audiology
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