Abstract:
OBJECTIVE:Inflammaging, a state of chronic inflammation in the elderly, is now thought to be a key element of the ageing process and contributor to age-related disease. In a previously published study, we identified a significant association between inflammation levels and severity of presbycusis among individuals aged 63 to 73 ('younger old") within an available audiometric range 0.5 to 4 kHz. Our aim was to see if this association would be identified among participants in the MRC national study of hearing, and whether the strength of the association would increase with greater age, or for very low or very high audiometric frequencies. DESIGN:Cross-sectional analysis of cohort data. STUDY SAMPLE:Three hundred and sixty community-dwelling adults age 60 years and over, representing all those with white blood cell count and audiometric data available. RESULTS:A significant independent association between (higher) WBC and (worse) hearing level was identified. This effect increased with age. The strongest association was among those over 75, for whom average hearing threshold levels among those with lower WBC was 17 dB better than those with higher WBC. CONCLUSIONS:The current findings support an association between inflammaging (a condition potentially amenable to pharmacological treatment or lifestyle management) and presbycusis.
journal_name
Int J Audioljournal_title
International journal of audiologyauthors
Verschuur C,Agyemang-Prempeh A,Newman TAdoi
10.3109/14992027.2014.891057subject
Has Abstractpub_date
2014-07-01 00:00:00pages
469-75issue
7eissn
1499-2027issn
1708-8186journal_volume
53pub_type
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journal_title:International journal of audiology
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