Calsyntenin-1 docks vesicular cargo to kinesin-1.

abstract：:Brd2 is a member of the bromodomain extra terminal (BET) protein family, which consists of four chromatin-interacting proteins that regulate gene expression. Each BET protein contains two N-terminal bromodomains, which recognize acetylated histones, and the C-terminal protein-protein interaction domain. Using a genome...

journal_title：Molecular biology of the cell

authors： Hnilicová J,Hozeifi S,Stejskalová E,Dušková E,Poser I,Humpolíčková J,Hof M,Staněk D

更新日期：2013-11-01 00:00:00

abstract：:Kinetochores are the proteinaceous complexes that assemble on centromeric DNA and direct eukaryotic chromosome segregation. The mechanisms by which higher eukaryotic cells define centromeres are poorly understood. Possible molecular contributors to centromere specification include the underlying DNA sequences and epig...

journal_title：Molecular biology of the cell

authors： Edwards NS,Murray AW

更新日期：2005-04-01 00:00:00

abstract：:During a search for genes controlling conidial dormancy in Aspergillus fumigatus, two dehydrin-like genes, DprA and DprB, were identified. The deduced proteins had repeated stretches of 23 amino acids that contained a conserved dehydrin-like protein (DPR) motif. Disrupted DprAΔ mutants were hypersensitive to oxidative...

journal_title：Molecular biology of the cell

authors： Wong Sak Hoi J,Lamarre C,Beau R,Meneau I,Berepiki A,Barre A,Mellado E,Read ND,Latgé JP

更新日期：2011-06-01 00:00:00

abstract：:Large cargoes require multiple receptors for efficient transport through the nuclear pore complex. The 60S ribosomal subunit is one of the bulkiest transport cargoes, and in yeast three different receptors, Crm1, Mex67/Mtr2, and Arx1, collaborate in its export. However, only Crm1, recruited by the adapter Nmd3, appear...

journal_title：Molecular biology of the cell

authors： Lo KY,Johnson AW

更新日期：2009-03-01 00:00:00

abstract：:During constitutive secretion, proteins synthesized at the endoplasmic reticulum (ER) are transported to the Golgi complex for processing and then to the plasma membrane for incorporation or extracellular release. This study uses a unique live-cell constitutive secretion assay to establish roles for the molecular moto...

journal_title：Molecular biology of the cell

authors： Bond LM,Peden AA,Kendrick-Jones J,Sellers JR,Buss F

更新日期：2011-01-01 00:00:00

abstract：:Cell migration is involved in various physiological and pathogenic events, and the complex underlying molecular mechanisms have not been fully elucidated. The simple eukaryote Dictyostelium discoideum displays chemotactic locomotion in stages of its life cycle. By characterizing a Dictyostelium mutant defective in che...

journal_title：Molecular biology of the cell

authors： Lin WC,Wang LC,Pang TL,Chen MY

更新日期：2015-03-15 00:00:00

abstract：:Endoplasmic reticulum (ER) calcium homeostasis is disrupted in diverse pathologies, including neurodegeneration, cardiovascular diseases, and diabetes. Temporally defining calcium dysregulation during disease progression, however, has been challenging. Here we describe secreted ER calcium-monitoring proteins (SERCaMPs...

journal_title：Molecular biology of the cell

authors： Henderson MJ,Wires ES,Trychta KA,Richie CT,Harvey BK

更新日期：2014-09-15 00:00:00

abstract：:Telomere dysfunction results in fertility defects in a number of organisms. Although data from fission yeast and Caenorhabditis elegans suggests that telomere dysfunction manifests itself primarily as defects in proper meiotic chromosome segregation, it is unclear how mammalian telomere dysfunction results in germ cel...

journal_title：Molecular biology of the cell

authors： Hemann MT,Rudolph KL,Strong MA,DePinho RA,Chin L,Greider CW

更新日期：2001-07-01 00:00:00

abstract：:Cdc42-associated tyrosine kinase 1 (ACK1) is a specific down-stream effector of Cdc42, a Rho family small G-protein. Previous studies have shown that ACK1 interacts with clathrin heavy chain and is involved in clathrin-coated vesicle endocytosis. Here we report that ACK1 interacted with epidermal growth factor recepto...

journal_title：Molecular biology of the cell

authors： Shen F,Lin Q,Gu Y,Childress C,Yang W

更新日期：2007-03-01 00:00:00

abstract：:Lamellipodia of crawling cells represent both the motor for cell advance and the primary building site for the actin cytoskeleton. The organization of actin in the lamellipodium reflects actin dynamics and is of critical importance for the mechanism of cell motility. In previous structural studies, the lamellipodial a...

journal_title：Molecular biology of the cell

authors： Verkhovsky AB,Chaga OY,Schaub S,Svitkina TM,Meister JJ,Borisy GG

更新日期：2003-11-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are extracellular proteases highly expressed at wound sites. However, the precise function of MMPs during reepithelialization in vivo has been elusive in mammalian models because of the high level of redundancy among the 24 mammalian MMPs. For this reason we used Drosophila melanogaste...

journal_title：Molecular biology of the cell

authors： Stevens LJ,Page-McCaw A

更新日期：2012-03-01 00:00:00

abstract：:Vascular endothelial (VE)-cadherin, the major adherens junction adhesion molecule in endothelial cells, interacts with p120-catenin and β-catenin through its cytoplasmic tail. However, the specific functional contributions of the catenins to the establishment of strong adhesion are not fully understood. Here we use bi...

journal_title：Molecular biology of the cell

authors： Oas RG,Nanes BA,Esimai CC,Vincent PA,García AJ,Kowalczyk AP

更新日期：2013-03-01 00:00:00

abstract：:The skin's epidermis is a multilayered epithelial tissue and the first line of defense against mechanical stress. Its barrier function depends on an integrated assembly and reorganization of cell-matrix and cell-cell junctions in the basal layer and on different intercellular junctions in suprabasal layers. However, h...

journal_title：Molecular biology of the cell

authors： Noethel B,Ramms L,Dreissen G,Hoffmann M,Springer R,Rübsam M,Ziegler WH,Niessen CM,Merkel R,Hoffmann B

更新日期：2018-09-15 00:00:00

abstract：:During meiosis, homologues are linked by crossover, which is required for bipolar chromosome orientation before chromosome segregation at anaphase I. The repetitive ribosomal DNA (rDNA) array, however, undergoes little or no meiotic recombination. Hyperrecombination can cause chromosome missegregation and rDNA copy nu...

journal_title：Molecular biology of the cell

authors： Li P,Jin H,Yu HG

更新日期：2014-10-01 00:00:00

abstract：:The homotypic fusion of yeast vacuoles requires the Rab-family GTPase Ypt7p and its effector complex, homotypic fusion and vacuole protein sorting complex (HOPS). Although the vacuolar kinase Yck3p is required for the sensitivity of vacuole fusion to proteins that regulate the Rab GTPase cycle-Gdi1p (GDP-dissociation ...

journal_title：Molecular biology of the cell

authors： Zick M,Wickner W

更新日期：2012-09-01 00:00:00

abstract：:The gene encoding NFKB1 is autoregulated, responding to NF-kappa B/Rel activation through NF-kappa B binding sites in its promoter, which also contains putative sites for Ets proteins. One of the Ets sites, which we refer to as EBS4, is located next to an NF-kappa B/Rel binding site, kB3, which is absolutely required ...

journal_title：Molecular biology of the cell

authors： Lambert PF,Ludford-Menting MJ,Deacon NJ,Kola I,Doherty RR

更新日期：1997-02-01 00:00:00

abstract：:Phosphatidylinositol transfer proteins (PITPs) regulate the interface between lipid metabolism and specific steps in membrane trafficking through the secretory pathway in eukaryotes. Herein, we describe the cis-acting information that controls PITPbeta localization in mammalian cells. We demonstrate PITPbeta localizes...

journal_title：Molecular biology of the cell

authors： Phillips SE,Ile KE,Boukhelifa M,Huijbregts RP,Bankaitis VA

更新日期：2006-06-01 00:00:00

abstract：:Previously published reports support the concept that, besides promoting homotypic intercellular adhesion, cadherins may transfer intracellular signals. However, the signaling pathways triggered by cadherin clustering and their biological significance are still poorly understood. We report herein that transfection of ...

journal_title：Molecular biology of the cell

authors： Lampugnani MG,Zanetti A,Breviario F,Balconi G,Orsenigo F,Corada M,Spagnuolo R,Betson M,Braga V,Dejana E

更新日期：2002-04-01 00:00:00

abstract：:Members of the LC7/Roadblock family of light chains (LCs) have been found in both cytoplasmic and axonemal dyneins. LC7a was originally identified within Chlamydomonas outer arm dynein and associates with this motor's cargo-binding region. We describe here a novel member of this protein family, termed LC7b that is als...

journal_title：Molecular biology of the cell

authors： DiBella LM,Sakato M,Patel-King RS,Pazour GJ,King SM

更新日期：2004-10-01 00:00:00

abstract：:The function currently attributed to tetraspanins is to organize molecular complexes in the plasma membrane by using multiple cis-interactions. Additionally, the tetraspanin CD9 may be a receptor that binds the soluble ligand PSG17, a member of the immunoglobulin superfamily (IgSF)/CEA subfamily. However, previous dat...

journal_title：Molecular biology of the cell

authors： Ellerman DA,Ha C,Primakoff P,Myles DG,Dveksler GS

更新日期：2003-12-01 00:00:00

abstract：:Recognition of surface-tethered antigens (Ags) by B-cells leads to the formation of an immune synapse that promotes Ag uptake for presentation onto MHC-II molecules. Extraction of immobilized Ags at the immune synapse of B-cells relies on the local secretion of lysosomes, which are recruited to the Ag contact site by ...

journal_title：Molecular biology of the cell

authors： Obino D,Diaz J,Sáez JJ,Ibañez-Vega J,Sáez PJ,Alamo M,Lankar D,Yuseff MI

更新日期：2017-04-01 00:00:00

abstract：:Glycerol and other polyols are used as osmoprotectants by many organisms. Several yeasts and other fungi can take up glycerol by proton symport. To identify genes involved in active glycerol uptake in Saccharomyces cerevisiae we screened a deletion mutant collection comprising 321 genes encoding proteins with 6 or mor...

journal_title：Molecular biology of the cell

authors： Ferreira C,van Voorst F,Martins A,Neves L,Oliveira R,Kielland-Brandt MC,Lucas C,Brandt A

更新日期：2005-04-01 00:00:00

abstract：:Yeast sulfur metabolism is transcriptionally regulated by the activator Met4. Met4 lacks DNA-binding ability and relies on interactions with Met31 and Met32, paralogous proteins that bind the same cis-regulatory element, to activate its targets. Although Met31 and Met32 are redundant for growth in the absence of methi...

journal_title：Molecular biology of the cell

authors： Carrillo E,Ben-Ari G,Wildenhain J,Tyers M,Grammentz D,Lee TA

更新日期：2012-05-01 00:00:00

abstract：:The structural maintenance of chromosomes (SMC) protein encoded by the fission yeast rad18 gene is involved in several DNA repair processes and has an essential function in DNA replication and mitotic control. It has a heterodimeric partner SMC protein, Spr18, with which it forms the core of a multiprotein complex. We...

journal_title：Molecular biology of the cell

authors： Taylor EM,Moghraby JS,Lees JH,Smit B,Moens PB,Lehmann AR

更新日期：2001-06-01 00:00:00

abstract：:Condensins are highly conserved proteins that are important for chromosome maintenance in nearly all forms of life. Although many organisms employ two forms of the condensin complex, the condensin genes in Tetrahymena have expanded even further. Here we report a form of condensin that is specifically active during sex...

journal_title：Molecular biology of the cell

authors： Howard-Till R,Tian M,Loidl J

更新日期：2019-05-15 00:00:00

abstract：:Yarrowia lipolytica Pex23p and Saccharomyces cerevisiae Pex30p, Pex31p, and Pex32p comprise a family of dysferlin domain-containing peroxins. We show that the deletion of their Pichia pastoris homologues, PEX30 and PEX31, does not affect the function or division of methanol-induced peroxisomes but results in fewer and...

journal_title：Molecular biology of the cell

authors： Yan M,Rachubinski DA,Joshi S,Rachubinski RA,Subramani S

更新日期：2008-03-01 00:00:00

abstract：:Stearoyl-coenzyme A desaturase (SCD) is a key regulator of membrane fluidity, turns over rapidly, and represents a prototype for selective degradation of resident proteins of the endoplasmic reticulum. Using detergent-solubilized, desaturase-induced rat liver microsomes we have characterized a protease that degrades S...

journal_title：Molecular biology of the cell

authors： Heinemann FS,Ozols J

更新日期：1998-12-01 00:00:00

abstract：:Saccharomyces cerevisiae mating pheromones induce production of Afr1p, a protein that negatively regulates pheromone receptor signaling and is required for normal formation of the projection of cell growth that becomes the site of cell fusion during conjugation. Afr1p interacts with Cdc12p, which belongs to a family o...

journal_title：Molecular biology of the cell

authors： Giot L,Konopka JB

更新日期：1997-06-01 00:00:00

abstract：:We previously reported the identification of a novel nuclear compartment detectable in heat-shocked HeLa cells that we termed stress-induced Src-activated during mitosis nuclear body (SNB). This structure is the recruitment center for heat shock factor 1 and for a number of RNA processing factors, among a subset of Se...

journal_title：Molecular biology of the cell

authors： Denegri M,Moralli D,Rocchi M,Biggiogera M,Raimondi E,Cobianchi F,De Carli L,Riva S,Biamonti G

更新日期：2002-06-01 00:00:00

abstract：:What started as a game of discovery for a child with a chemistry set has resulted in a lifetime of fulfillment and dedication to science. It is deeply rewarding to continuously let my curiosity ask questions for which there are no known answers. Equally rewarding has been the opportunity to mentor young students and p...

journal_title：Molecular biology of the cell

authors： Garcia JV

更新日期：2013-11-01 00:00:00