Treatment late effects in long-term survivors of pediatric sarcoma.

abstract：BACKGROUND:This study aimed to compare the health related quality of life (HRQoL) of children and adolescents after malignant bone tumor surgery of the leg with healthy controls. PROCEDURE:Patients between 8 and 25 years old were cross-sectional recruited. Patients under 16 years of age received the TNO (Netherlands O...

journal_title：Pediatric blood & cancer

authors： Bekkering WP,Vliet Vlieland TP,Koopman HM,Schaap GR,Schreuder HW,Beishuizen A,Tissing WJ,Hoogerbrugge PM,Anninga JK,Taminiau AH

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Symptoms of epidural compression (SEC) in children with neuroblastoma (particularly infants) may be misinterpreted, leading to delay in diagnosis. PATIENTS AND METHODS:Clinical, imaging and follow-up data of 34 infants with neuroblastoma and SEC diagnosed between 2000 and 2011 at Italian AIEOP centers were ...

journal_title：Pediatric blood & cancer

authors： De Bernardi B,Quaglietta L,Haupt R,Castellano A,Tirtei E,Luksch R,Mastrangelo S,Viscardi E,Indolfi P,Cellini M,Tamburini A,Erminio G,Gandolfo C,Sorrentino S,Vetrella S,Gigliotti AR

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The objective of this retrospective study was to assess protection against vaccine preventable diseases (VPDs) in children treated for acute lymphoblastic leukemia (ALL). PROCEDURE:Clinical characteristics and vaccination records were collected. Antibodies against VPDs were measured after completion of chem...

journal_title：Pediatric blood & cancer

authors： de de la Fuente Garcia I,Coïc L,Leclerc JM,Laverdière C,Rousseau C,Ovetchkine P,Tapiéro B

更新日期：2017-02-01 00:00:00

abstract：:We report two survivors of Wilms tumor (WT) who developed inflammatory myofibroblastic tumor (IMT). The first patient had IMT in the mainstem bronchus 1 year after WT therapy that included vincristine, dactinomycin, doxorubicin (VDA) and whole lung radiation therapy (XRT). The second patient had IMT in the cecum 7 yea...

journal_title：Pediatric blood & cancer

authors： Ortiz MV,Rossi CT,Hill DA,Guzzetta PC,Qureshi F,Dome JS

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Physical fitness is an important determinant of quality of life (QOL) after hematopoietic stem cell transplantation. Cardiac function can influence exercise performance. The aim of this study was to assess these factors and their interrelationship. PROCEDURE:Children underwent cardiopulmonary exercise testi...

journal_title：Pediatric blood & cancer

authors： Vandekerckhove K,De Waele K,Minne A,Coomans I,De Groote K,Panzer J,Dhooge C,Bordon V,De Wolf D,Boone J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Several sickle cell clinical trials have closed due to inability to enroll patients. To limit the early cessation of a proposed clinical trial due to low accrual rates, we sought to better understand barriers and facilitators to enrolling parents of children with sickle cell anemia (SCD) into clinical trials...

journal_title：Pediatric blood & cancer

authors： Lebensburger JD,Sidonio RF,Debaun MR,Safford MM,Howard TH,Scarinci IC

更新日期：2013-08-01 00:00:00

abstract：:X-linked lymphoproliferative syndrome (XLP) is caused by mutations in SH2D1A, and is associated with overwhelming infectious mononucleosis, aplastic anemia, hypogammaglobulinemia, and B-cell lymphomas. However, the frequency of SH2D1A mutations in males who present with B NHL is unknown. Five cases of XLP were diagnos...

journal_title：Pediatric blood & cancer

authors： Sandlund JT,Shurtleff SA,Onciu M,Horwitz E,Leung W,Howard V,Rencher R,Conley ME

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Subspecialty-specific normative values for clinical productivity of practicing pediatric hematologist/oncologists have not been well established. This information could be a useful adjunct in administrative decision-making in areas such as necessary levels of physician staffing and development of compensatio...

journal_title：Pediatric blood & cancer

authors： Griffin TC,Hutter JJ,Johnson KK,Moscow JA

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Bleomycin is associated with pulmonary toxic side effects including pneumonitis and pulmonary fibrosis. We evaluated the prevalence of long-term pulmonary function abnormalities in children receiving bleomycin therapy in the context of current chemotherapeutic regimens. METHODS:A retrospective review of pat...

journal_title：Pediatric blood & cancer

authors： De A,Guryev I,LaRiviere A,Kato R,Wee CP,Mascarenhas L,Keens TG,Venkatramani R

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Nephrogenic rests (NRs) are abnormally persistent foci of embryonal cells, thought to be the precursor lesion of Wilms tumors (WTs). To date, their presence has not been systematically examined in WTs treated with preoperative chemotherapy. METHODS:A systematic analysis of the data on NRs in WTs treated wit...

journal_title：Pediatric blood & cancer

authors： Vujanić GM,Apps JR,Moroz V,Ceroni F,Williams RD,Sebire NJ,Pritchard-Jones K

更新日期：2017-11-01 00:00:00

abstract：:Hemorrhagic cystitis (HC) is a common complication after stem cell transplantation (SCT) that occurs more frequently in patients with Fanconi anemia (FA) because of hypersensitivity of their cells to the agents used in the preparation for SCT (chemo and radiation). Many HC cases respond to therapy with hyperhydration ...

journal_title：Pediatric blood & cancer

authors： Al-Seraihi A,Ayas M

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Although respiratory syncytial virus (RSV) is the leading cause of pediatric lower respiratory tract infections, the burden of RSV in children with sickle cell disease (SCD) is unknown. METHODS:We conducted a retrospective, nested, case-control study of children with SCD <18 years who had respiratory viral ...

journal_title：Pediatric blood & cancer

authors： Rostad CA,Maillis AN,Lai K,Bakshi N,Jerris RC,Lane PA,Yee ME,Yildirim I

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The DNA methylating agent temozolomide was developed primarily for treatment of glioblastoma. However, preclinical data have suggested a broader application for treatment of childhood cancer. Temozolomide was tested against the PPTP solid tumor and ALL models. PROCEDURES:Temozolomide was tested against the ...

journal_title：Pediatric blood & cancer

authors： Keir ST,Maris JM,Reynolds CP,Kang MH,Kolb EA,Gorlick R,Lock R,Carol H,Morton CL,Wu J,Kurmasheva RT,Houghton PJ,Smith MA

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Survival of osteosarcoma patients has reached a plateau with the addition of chemotherapy and in part predicted based on histologic response. Risk-adapted therapy might be an alternative approach. We aimed to identify risk groups using clinical variables available at time of diagnosis in order to better pred...

journal_title：Pediatric blood & cancer

authors： Lee JA,Kim MS,Kim DH,Lim JS,Park KD,Song WS,Cho WH,Lee SY,Jeon DG

更新日期：2009-03-01 00:00:00

abstract：:Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor arising mainly in the orofacial bones. Among more than 200 cases described in articles, only seven cases involved orbital regions. We present a case of newborn with recurrent MNTI in the lateral wall of right orbit. The patient underwent complete surgic...

journal_title：Pediatric blood & cancer

authors： Nakanishi K,Hori H,Matsubara T,Matsuda K,Deguchi T,Komada Y

更新日期：2008-09-01 00:00:00

abstract：:VPS45-associated severe congenital neutropenia (SCN) is a rare disorder characterized by life-threating infections, neutropenia, neutrophil and platelet dysfunction, poor response to filgrastim, and myelofibrosis with extramedullary hematopoiesis. We present a patient with SCN due to a homozygous c.1403C>T (p.P468L) m...

journal_title：Pediatric blood & cancer

authors： Shah RK,Munson M,Wierenga KJ,Pokala HR,Newburger PE,Crawford D

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:While pediatric low-grade glioma/glioneuronal tumors (LGG/LGGNTs) are considered slow-growing, indolent tumors with excellent long-term prognosis, mortality due to the disease is not unknown. Few studies have addressed the cause of death in this population. METHODS:Retrospective review of clinicopathologic ...

journal_title：Pediatric blood & cancer

authors： Upadhyaya SA,Ghazwani Y,Wu S,Broniscer A,Boop FA,Gajjar A,Qaddoumi I

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Few data exist regarding the clinical outcome of patients with Ewing sarcoma (EWS) treated with pencil beam scanning proton therapy (PT). We report the outcome of children, adolescents and young adults (AYA) treated with PT at the Paul Scherrer Institute. MATERIALS:Thirty-eight patients (median age, 9.9 yea...

journal_title：Pediatric blood & cancer

authors： Weber DC,Murray FR,Correia D,Bolsi A,Frei-Welte M,Pica A,Lomax AJ,Schneider R,Bachtiary B

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Carboplatin is the most effective drug in retinoblastoma but systemic clearance is variable in young patients. While most regimens use a flat dose, individualized targeting may provide a more adjusted systemic exposure. PATIENTS AND METHODS:We compared carboplatin doses between two groups of children with r...

journal_title：Pediatric blood & cancer

authors： Allen S,Wilson MW,Watkins A,Billups C,Qaddoumi I,Haik BH,Rodriguez-Galindo C

更新日期：2010-07-15 00:00:00

abstract：:Squamous cell carcinoma of the anal canal in children is rare. To date, the etiology and outcome of this condition have been not fully understood. Here, we report an 11-year-old child with anal canal cancer who had concomitant disorders of sex development. Radiotherapy followed by salvage surgery achieved disease-free...

journal_title：Pediatric blood & cancer

authors： Watanabe T,Horikawa R,Masaki H,Yoshioka T,Matsumoto K,Kanamori Y

更新日期：2016-07-01 00:00:00

abstract：:Almost all of what is known about neurologic and cognitive development in hemophilia derives from the Hemophilia Growth and Development Study, conducted during an era when treatment regimens and comorbidities differed significantly from the current environment. Results suggested hemophilia and human immunodeficiency v...

journal_title：Pediatric blood & cancer

authors： Buranahirun C,Walsh KS,Mrakotsky C,Croteau SE,Rajpurkar M,Kearney S,Hannemann C,Wilkening GN,Shapiro KA,Cooper DL

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Childhood cancer survivors (CCS) are at risk of developing long-term morbidity, which is likely to be presented to a primary care physician (PCP). Therefore, insight into CCS's PCP-based health care use is needed. We investigated the volume and underlying health problems of PCP-based health care use and the ...

journal_title：Pediatric blood & cancer

authors： Streefkerk N,Heins MJ,Teepen JC,Feijen EAM,Bresters D,van Dulmen-den Broeder E,van der Heiden-van der Loo M,van den Heuvel-Eibrink MM,van Leeuwen FE,Loonen JJ,van der Pal HJH,Ronckers CM,Versluys AB,Tissing WJE,Korevaar JC,

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Although hematopoietic stem cell transplantation (HSCT) is offered as a curative therapy for pediatric myelodysplastic syndrome (MDS), it may cause severe complications and mortality. Several reports have shown the efficacy of immunosuppressive therapy (IST) in adult patients with refractory anemia (RA), but...

journal_title：Pediatric blood & cancer

authors： Hasegawa D,Manabe A,Yagasaki H,Ohtsuka Y,Inoue M,Kikuchi A,Ohara A,Tsuchida M,Kojima S,Nakahata T,Japanese Childhood MDS Study Group.

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Clear cell sarcoma of the kidney (CCSK) is known for its propensity to metastasize to bone, but it also spreads to other sites including the brain. This study was undertaken to describe the treatment and outcomes of patients with recurrent CCSK involving the brain. METHODS:A retrospective records review was...

journal_title：Pediatric blood & cancer

authors： Radulescu VC,Gerrard M,Moertel C,Grundy PE,Mathias L,Feusner J,Diller L,Dome JS

更新日期：2008-02-01 00:00:00

abstract：:To assess safety and tolerability, we administered valacyclovir, an oral anti-viral medication that inhibits erythrocyte sickling in vitro, to 14 subjects with sickle-cell anemia for 1 week at a standard dose of 1,000 mg every 8 hr. No clinically significant adverse effects occurred. In 11 subjects in steady state, th...

journal_title：Pediatric blood & cancer

authors： Ender KL,DeBellis RH,Erlanger BF,Billote GB,Brittenham GM

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Severe congenital neutropenia is a rare disease, and autosomal dominantly inherited ELANE mutation is the most frequently observed genetic defect in the registries from North America and Western Europe. However, in eastern countries where consanguineous marriages are common, autosomal recessive forms might b...

journal_title：Pediatric blood & cancer

authors： Yılmaz Karapınar D,Patıroğlu T,Metin A,Çalışkan Ü,Celkan T,Yılmaz B,Karakaş Z,Karapınar TH,Akıncı B,Özkınay F,Onay H,Yeşilipek MA,Akar HH,Tüysüz G,Tokgöz H,Özdemir GN,Aslan Kıykım A,Karaman S,Kılınç Y,Oymak Y,Küpe

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Resource-rich countries tend to have a higher incidence of childhood acute lymphoblastic leukemia (ALL), whereas lower rates are seen in more deprived countries. This study describes the incidence of childhood acute leukemia in Brazil, an upper middle-income country, based on data from 16 population-based ca...

journal_title：Pediatric blood & cancer

authors： de Souza Reis R Sr,de Camargo B,de Oliveira Santos M,de Oliveira JM,Azevedo Silva F,Pombo-de-Oliveira MS

更新日期：2011-01-01 00:00:00

abstract：:In Wilms tumor (WT), mutations in the gene encoding p53, TP53, are correlated with anaplasia; however TP53 variants have not been studied in favorable histology (FH) WTs. A single nucleotide polymorphism of TP53 encoding either arginine or proline at codon 72 is suggested to alter in vitro p53 behavior. Therefore, we ...

journal_title：Pediatric blood & cancer

authors： Cost NG,Mitui M,Khokhar S,Wickiser JE,Baker LA,Rakheja D

更新日期：2012-08-01 00:00:00

abstract：:Neuroblastoma is the most common extracranial solid tumor of childhood, and the outcomes for children with high-risk and relapsed disease remain poor. However, new international strategies for risk stratification and for treatment based on novel tumor targets and including immunotherapy are being employed in attempts ...

journal_title：Pediatric blood & cancer

authors： Zage PE,Louis CU,Cohn SL

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Premature newborns are vulnerable to iron imbalance, although the iron homeostasis during the perinatal period remains unclear. To clarify the iron metabolism of premature infants, we measured serum prohepcidin concentrations of preterm infants, and analyzed the association with iron parameters. METHODS:Sev...

journal_title：Pediatric blood & cancer

authors： Kitajima J,Ohga S,Kinjo T,Ochiai M,Takahata Y,Honjo S,Hara T

更新日期：2011-02-01 00:00:00