Abstract：
BACKGROUND:The DNA methylating agent temozolomide was developed primarily for treatment of glioblastoma. However, preclinical data have suggested a broader application for treatment of childhood cancer. Temozolomide was tested against the PPTP solid tumor and ALL models. PROCEDURES:Temozolomide was tested against the PPTP in vitro panel at concentrations ranging from 0.1 to 1,000 µM and was tested against the PPTP in vivo panels at doses from 22 to 100 mg/kg administered orally daily for 5 days, repeated at day 21. RESULTS:In vitro temozolomide showed cytotoxicity with a median relative IC50 (rIC50 ) value of 380 µM against the PPTP cell lines (range 1 to > 1,000 µM). The three lines with rIC50 values lesser than 10 µM had low MGMT expression compared to the remaining cell lines. In vivo temozolomide demonstrated significant toxicity at 100 mg/kg, but induced tumor regressions in 15 of 23 evaluable solid tumor models (13 maintained CR [MCR], 2 CR) and 5 of 8 ALL models (3 MCR, 2 CR). There was a steep dose response curve, with lower activity at 66 mg/kg temozolomide and with tumor regressions at 22 and 44 mg/kg restricted to models with low MGMT expression. CONCLUSIONS:Temozolomide demonstrated high level antitumor activity against both solid tumor and leukemia models, but also elicited significant toxicity at the highest dose level. Lowering the dose of TMZ to more closely match clinical exposures markedly reduced the antitumor activity for many xenograft lines with responsiveness at lower doses closely related to low MGMT expression.
journal_name
Pediatr Blood Cancerjournal_title
Pediatric blood & cancerauthors
Keir ST,Maris JM,Reynolds CP,Kang MH,Kolb EA,Gorlick R,Lock R,Carol H,Morton CL,Wu J,Kurmasheva RT,Houghton PJ,Smith MAdoi
10.1002/pbc.24368subject
Has Abstractpub_date
2013-05-01 00:00:00pages
783-90issue
5eissn
1545-5009issn
1545-5017journal_volume
60pub_type
杂志文章abstract：BACKGROUND:Advanced irradiation techniques, including intensity-modulated radiation therapy (IMRT), aim to limit irradiation to adjoining tissues by conforming beams to a well-defined volume. In intracranial germinomas, whole-ventricular IMRT decreases the volume of irradiation to surrounding parenchyma. This study exa...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.28005
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:The combined inhibition of insulin-growth factor type 1 receptor (IGF-1R) and the mammalian target of rapamycin (mTOR) has shown activity in preclinical models of pediatric sarcoma and in adult sarcoma patients. We evaluated the activity of the anti-IGF-1R antibody cixutumumab with the mTOR inhibitor temsiro...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,多中心研究
doi：10.1002/pbc.25334
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Hematopoietic stem cell transplantation (HSCT) provides a curative therapy for children severely affected by sickle cell disease (SCD). Rejection-free survival after matched sibling donor (MSD) HSCT is very high, but adoption of HSCT as a curative SCD therapy has been slow. In this study, we assess providers...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.28861
更新日期：2021-03-01 00:00:00
abstract：:The provision of tele-practice symptom management is often without the provision of evidence-based guidelines. Under the auspices of the Pediatric Oncology Group of Ontario, a nursing task force was established to appraise the evidence and develop guidelines. Promising new efforts to enhance symptom management through...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,实务指引,评审
doi：10.1002/pbc.22993
更新日期：2011-10-01 00:00:00
abstract：:In HLH-94, the first prospective international treatment study for hemophagocytic lymphohistiocytosis (HLH), diagnosis was based on five criteria (fever, splenomegaly, bicytopenia, hypertriglyceridemia and/or hypofibrinogenemia, and hemophagocytosis). In HLH-2004 three additional criteria are introduced; low/absent NK...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.21039
更新日期：2007-02-01 00:00:00
abstract：:Time-to-antibiotic administration (TTA) has been suggested as a quality-of-care (QOC) measure for pediatric oncology patients with febrile neutropenia (FN). Unknown, however, is to what extent pediatric oncology centers utilize TTA. Therefore, we designed and administered an electronic survey (68% response rate) of pr...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.23148
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Most commonly a tissue diagnosis of rhabdomyosarcoma (RMS) in children is made by biopsy as opposed to primary resection. Open surgical procedures are often recommended to obtain sufficient material for accurate and complete diagnostic work up. Our institution has routinely used image-guided needle biopsies ...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.22059
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Survival rates for patients with bone tumors have increased dramatically over the past few decades. Unfortunately, many patients face functional limitations resulting from disease management, but there is little evidence regarding physical functioning in adolescents with bone tumors. This lack is largely due...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,评审
doi：10.1002/pbc.20383
更新日期：2005-10-15 00:00:00
abstract：BACKGROUND:To investigate the incidence, clinical characteristics and survival of malignant tumours of the gastrointestinal tract in children in the West Midlands in Britain over a 44-year span time, to identify any change over this period and to compare the data with the world literature. PROCEDURE:Retrospective popu...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.20086
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:The role of local analgesics for lumbar punctures (LPs) in pediatric oncology patients has not been specifically studied. AIM:To compare the efficacy of eutectic mixture of local anesthetics (EMLA) cream to 1% lidocaine injection for LPs. METHOD:This was a retrospective observational study of all patients ...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.27957
更新日期：2019-11-01 00:00:00
abstract：:Acute splenic sequestration crisis (ASSC) is a hematological emergency in young children with sickle cell disease (SCD), characterized by worsening anemia and splenomegaly, usually with reticulocytosis and thrombocytopenia. Transient aplastic crisis (TAC) due to parvovirus B19 infection occurs in older children with S...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.22035
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Population-based evidence suggests that lower socioeconomic status (SES) negatively impacts the overall survival (OS) of children with leukemia; however, the relationships between SES and treatment-related mortality, relapse, and timing of relapse remain unclear. PROCEDURE:We examined OS, event-free surviva...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.25928
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Clear cell sarcoma of the kidney (CCSK) is known for its propensity to metastasize to bone, but it also spreads to other sites including the brain. This study was undertaken to describe the treatment and outcomes of patients with recurrent CCSK involving the brain. METHODS:A retrospective records review was...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.21131
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Currently, there is no standardized treatment for adolescents, aged 15 years or older, with mature B-cell non-Hodgkin lymphoma (B-NHL), although this age group has been reported to have a poorer prognosis than younger patients. PROCEDURE:The present study analyzed the data of 321 patients with B-NHL, enroll...
journal_title：Pediatric blood & cancer
pub_type： 临床试验,杂志文章
doi：10.1002/pbc.27068
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Iron overload is well documented in patients with β-thalassemia major, and patients who have undergone hematopoietic stem cell transplantation (HSCT) remain at risk as a result of pre- and immediate post-HSCT transfusions. PROCEDURE:This is a prospective, randomized, 1-year clinical trial that compares the ...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,随机对照试验
doi：10.1002/pbc.26213
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Abandonment of treatment is one of the toughest challenges to deal with in pediatric oncology. It leads to unnecessary mortality and morbidity in patients from low- and middle-income countries. PROCEDURE:The objective of our retrospective study was to determine the prevalence and predictors for abandonment ...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.26818
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:The transition from the pediatric setting to adult care is a well-described period of morbidity and mortality for persons with sickle cell disease (SCD). We sought to measure the feasibility and effectiveness of providing skill-based educational handouts on improving self-management and transition readiness ...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.27722
更新日期：2019-07-01 00:00:00
abstract：INTRODUCTION:To describe the quality of life (QOL) of pediatric brain tumor survivors (PBTSs) prospectively and to identify potential medical, personal and family contextual factors associated with QOL. METHODS:Ninety-one PBTSs (8-16 years) who were off treatment and attending a regular classroom participated. Self- a...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.26481
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Sickle cell disease (SCD) is an important, hidden cause of childhood mortality worldwide. It is most prevalent in sub-Saharan Africa where national newborn screening programs remain unavailable and most children in rural areas are never diagnosed. We conducted a study at a rural district hospital ...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.28620
更新日期：2020-11-01 00:00:00
abstract：:Ameloblastic fibro-odontosarcoma (AFOS) is an extremely rare malignant odontogenic tumor. Complete surgical excision is the treatment of choice. Deaths due to disease recurrence and/or progression are documented. Here, we report the case of a 15-year-old female with multiple recurrent AFOS. She responded to chemothera...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.25627
更新日期：2015-11-01 00:00:00
abstract：:Beckwith-Wiedemann syndrome (BWS) is a genetic overgrowth and cancer predisposition syndrome, associated with both benign and malignant adrenal findings. Literature review and an institutional case series elucidate the wide spectrum of adrenal findings in BWS patients. The altered expression of the 11p15 region is lik...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,评审
doi：10.1002/pbc.26432
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:The views and clinical practice of children's cancer units were surveyed regarding management of central venous catheter (CVC) occlusion (CVC-occlusion), CVC-related thrombosis (CVC-thrombosis) and thromboembolism (CVC-thromboembolism). PROCEDURE:A questionnaire was sent to all 22 United Kingdom Children's ...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,多中心研究
doi：10.1002/pbc.21332
更新日期：2008-04-01 00:00:00
abstract：:Most publications report the adverse (negative) health issues in childhood cancer survivors. Presenting information to the newly diagnosed patient in a positive manner is advocated, while noting that recurrence is the most likely adverse event. Re-analysis of population-based studies on life-threatening toxicities fro...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,评审
doi：10.1002/pbc.22975
更新日期：2011-12-15 00:00:00
abstract：BACKGROUND:Premature newborns are vulnerable to iron imbalance, although the iron homeostasis during the perinatal period remains unclear. To clarify the iron metabolism of premature infants, we measured serum prohepcidin concentrations of preterm infants, and analyzed the association with iron parameters. METHODS:Sev...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.22773
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Ultrasound-guided (USG) cannulation of the brachiocephalic vein (BCV) is gaining worldwide consensus for central venous access in children. This study reports a 20-month experience with this approach in children. METHODS:All patients who underwent percutaneous USG central venous catheter (CVC) positioning i...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.26202
更新日期：2017-02-01 00:00:00
abstract：:Opportunities for cancer prevention in adolescents range from limitation of sun exposure to the use of human papillomavirus vaccines. Those who develop malignant disease experience longer waiting times for diagnosis and treatment than do children, especially when referred to adult treatment centers, and they are less ...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,评审
doi：10.1002/pbc.20634
更新日期：2006-03-01 00:00:00
abstract：:Ovarian tumors have a low incidence in childhood, accounting for 1% of malignancies within the ages of 0-17 years. Small cell carcinoma of the ovary is a rare histology and historically has a poor prognosis. We report a case of an 11-year-old female diagnosed with small cell carcinoma of the ovary and hypercalcemia (S...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.22184
更新日期：2009-12-15 00:00:00
abstract：:Hereditary deficiency in human glucose-6-phosphate dehydrogenase (G6PD) is mostly caused by single nucleotide change in the G6PD gene which leads to single amino acid substitution. In 104 cases of Chinese children with G6PD deficiency, RT-PCR-DGGE (denaturing gradient gel electrophoresis) combined with DNA sequencing ...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.22517
更新日期：2010-08-01 00:00:00
abstract：:Twenty-eight patients were maintained on subcutaneous immunoglobulin replacement for persistent B-cell aplasia and agammaglobulinemia following CD19-targeted chimeric antigen receptor T-cell therapy for B-cell lymphoblastic leukemia. Patients were transitioned from intravenous to subcutaneous immunoglobulin replacemen...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.28092
更新日期：2020-03-01 00:00:00
abstract：:There is growing evidence that some chronic diseases are caused, or promoted, by infectious disease. 'Population mixing' has been used as a proxy for the range and dose of infectious agents circulating in a community. Given the speculation over the role of population mixing in many chronic diseases, we review the vari...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,评审
doi：10.1002/pbc.21570
更新日期：2008-08-01 00:00:00
