Anal Canal Carcinoma in a Child With Disorders of Sex Development.

Abstract:

:Squamous cell carcinoma of the anal canal in children is rare. To date, the etiology and outcome of this condition have been not fully understood. Here, we report an 11-year-old child with anal canal cancer who had concomitant disorders of sex development. Radiotherapy followed by salvage surgery achieved disease-free survival of 3 years. Since overexpression of cell cycle regulatory protein p16 was immunohistochemically evident in tumor tissue, human papillomavirus infection was considered as a causative factor in the carcinogenesis.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Watanabe T,Horikawa R,Masaki H,Yoshioka T,Matsumoto K,Kanamori Y

doi

10.1002/pbc.25988

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

1293-5

issue

7

eissn

1545-5009

issn

1545-5017

journal_volume

63

pub_type

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