Lentiviral-mediated fetal gene therapy for monogenic disorders: development of an in vitro rabbit model.

abstract：INTRODUCTION:To determine the accuracy of estimated fetal weight (EFW) at the limit of viability in a delivery room setting and its impact on the prediction of neonatal outcome. MATERIAL AND METHODS:In this retrospective, single-center cohort study we included patients with preterm birth between 230/7 and 260/7 weeks ...

journal_title：Fetal diagnosis and therapy

authors： Zdanowicz JA,Huber C,Gerull R,Mueller M,Raio L,Surbek D

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To validate previously computed correction factors for free β-human chorionic gonadotrophin (fβ-hCG) and pregnancy-associated plasma protein-A (PAPP-A) in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) pregnancies with hormone treatment and to determine the effect on false-positive r...

journal_title：Fetal diagnosis and therapy

authors： Engels MA,Pajkrt E,Groot DT,Schats R,Twisk JW,van Vugt JM

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:To determine if maternal serum levels of 25(OH)D at 11-13 weeks' gestation are altered in pregnancies that subsequently deliver small for gestational age (SGA) neonates and whether the levels are related to placental function reflected in serum concentration of pregnancy-associated plasma protein-A (PAPP-A)....

journal_title：Fetal diagnosis and therapy

authors： Ertl R,Yu CK,Samaha R,Akolekar R,Nicolaides KH

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the perinatal and long-term neurodevelopmental outcome in a cohort of children with intracranial haemorrhage (ICH) due to fetal and neonatal alloimmune thrombocytopenia (FNAIT) and to clearly outline the burden of this disease. SUBJECTS AND METHODS:We performed an observational cohort study and ...

journal_title：Fetal diagnosis and therapy

authors： Winkelhorst D,Kamphuis MM,Steggerda SJ,Rijken M,Oepkes D,Lopriore E,van Klink JMM

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To determine whether myomectomy during pregnancy in selected patients improves outcome. METHODS:Retrospective analysis of 18 patients who underwent myomectomy between the 6th and 24th week of gestational age. Surgical management of tumors was required on the basis of the characteristics of the myomas and sym...

journal_title：Fetal diagnosis and therapy

authors： De Carolis S,Fatigante G,Ferrazzani S,Trivellini C,De Santis L,Mancuso S,Caruso A

更新日期：2001-03-01 00:00:00

abstract：:Acute hydramnios is a rare complication of pregnancy, usually of idiopathic etiology and associated with a very poor perinatal prognosis. In this single case report, acute hydramnios at 21 weeks' gestation, associated with fetal CMV infection, was treated by a single large volume reduction amniocentesis combined with ...

journal_title：Fetal diagnosis and therapy

authors： Bondagji N,Manning FA,Martel J,Harman CR,Morrison I

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to review previous work reporting the concentration of solutes measured in maternal circulation, extra-embryonic celomic fluid, and amniotic fluid, to gain insights into the mechanism that could lead to compartmentalization of fluid and solutes within the gestational sac prior to th...

journal_title：Fetal diagnosis and therapy

authors： Santolaya-Forgas J,De Leon-Luis J,Espinoza J,Gonçalves LF,Romero R

更新日期：2006-01-01 00:00:00

abstract：:We present a case where the embryo showed an increased nuchal edema and a metabolic disorder. At 31 weeks of gestation the fetus developed a cardiomegaly and a hydrops. In this case, a long-chain 3-hydroxacyl-coenzyme A dehydrogenase deficiency (LCHAD deficiency) was confirmed by biochemical investigations in cultured...

journal_title：Fetal diagnosis and therapy

authors： Tercanli S,Uyanik G,Hösli I,Cagdas A,Holzgreve W

更新日期：2000-11-01 00:00:00

abstract：:Functional residual capacity (FRC) was measured at 2-8 (median 4) weeks of age in 100 infants whose mothers had entered a randomized trial of amniocentesis versus chorion villus sampling (CVS) at 10-13 weeks gestation. At measurement all of the infants were well and none had respiratory problems. No significant differ...

journal_title：Fetal diagnosis and therapy

authors： Thompson PJ,Greenough A,Nicolaides KH

更新日期：1991-01-01 00:00:00

abstract：:This report describes a fetus with a large multiloculated cystic liver mass. Two small abdominal cysts were seen on ultrasound at 19 weeks of gestation but the patient was referred to us at 23 weeks, after the mass had grown to 8.0 x 5.6 x 7.0 cm, displacing intra-abdominal organs, heart and diaphragm. There was a sma...

journal_title：Fetal diagnosis and therapy

authors： Laberge JM,Patenaude Y,Desilets V,Cartier L,Khalife S,Jutras L,Chen MF

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVES:To examine the assumption that amniotic fluid alpha-fetoprotein (AFAFP) levels are different in female and male twin fetuses. DESIGN:Amniotic fluid levels of AFP in pregnancies with female and male fetuses in gender-concordant and gender-discordant twins were compared. A t test of p < 0.05 was considered si...

journal_title：Fetal diagnosis and therapy

authors： Sharony R,Drugan A,Amiel A,Grinshpun-Cohen J,Markov S,Fejgin MD

更新日期：2003-07-01 00:00:00

abstract：INTRODUCTION:The aim of this study is to evaluate the incidence and causes of intentional fetal and neonatal demise in twin-twin transfusion syndrome (TTTS). MATERIAL AND METHODS:All TTTS pregnancies managed at our centre between 2000 and 2014 were included. We evaluated incidence and causes of intentional fetal/neona...

journal_title：Fetal diagnosis and therapy

authors： Spruijt MS,Tameeris E,Zhao DP,Middeldorp JM,Haak MC,Oepkes D,Lopriore E

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:To determine whether brachial artery flow-mediated dilation (FMD) assessed by ultrasonography during the late first trimester is able to predict the occurrence of hypertensive disorders during pregnancy. METHODS:Maternal endothelial function was assessed by flow-mediated dilation (FMD) of the brachial arter...

journal_title：Fetal diagnosis and therapy

authors： Alves JA,Miyague AH,de Sousa PC,Maia SB,Costa Fda S,Martins WP

更新日期：2015-01-01 00:00:00

abstract：:In order to elucidate the effects of corticosteroids on fetal hearts during midtrimester, pregnant rats were injected with a daily dose of betamethasone (1 mg/kg) from the 12th day through the 17th day of pregnancy. The fetal cardiovascular and pulmonary systems were studied on the 21st day of pregnancy (term). The tr...

journal_title：Fetal diagnosis and therapy

authors： Wu FF,Momma K,Takao A

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:To report on the initial experience in a single Brazilian university clinic of the use of fetoscopic endotracheal occlusion (FETO) to treat severe isolated congenital diaphragmatic hernia (CDH). METHODS:The inclusion criteria for FETO for this prospective study were isolated CDH and intrathoracic herniation ...

journal_title：Fetal diagnosis and therapy

authors： Peralta CF,Sbragia L,Bennini JR,de Fátima Assunção Braga A,Sampaio Rousselet M,Machado Rosa IR,Barini R

更新日期：2011-01-01 00:00:00

abstract：:Although δ-globin gene mutations have no clinical implications, association of β- and δ-thalassemia may lead to misdiagnosis. We describe the case of a Chinese woman who was assumed to have an α-thalassemia heterozygote, but was later shown to have β-thalassemia with a normal amount of HbA(2) caused by the -77 mutatio...

journal_title：Fetal diagnosis and therapy

authors： Li J,Xie XM,Zhou JY,Li DZ

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to describe the association between fetal echogenic bowel (FEB) diagnosed during the second trimester and adverse perinatal outcomes in an Australian antenatal population. METHODS:A retrospective analysis of ultrasound scans was performed between March 1, 2004 and March 1, 2009 a...

journal_title：Fetal diagnosis and therapy

authors： Ameratunga DM,Said JM,Reidy K,Palma-Dias R

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the relationship between maternal serum levels of human placental growth hormone (hPGH) and fetal Down syndrome at gestational midtrimester. METHODS:We retrospectively analyzed samples of serum from 21 women with Down syndrome pregnancies detected at gestational midtrimester. The samples were obt...

journal_title：Fetal diagnosis and therapy

authors： Papadopoulou E,Sifakis S,Giahnakis E,Fragouli Y,Karkavitsas N,Koumantakis E,Kalmanti M

更新日期：2008-01-01 00:00:00

abstract：:Two cases of lissencephaly were prenatally diagnosed by a magnetic resonance image (MRI). Smooth surface of brain and remarkable sylvian fissure, which were barely detectable by ultrasound, were easily observed in MRI. MRI is the most appropriate tool in diagnosing lissencephaly. ...

journal_title：Fetal diagnosis and therapy

authors： Okamura K,Murotsuki J,Sakai T,Matsumoto K,Shirane R,Yajima A

更新日期：1993-01-01 00:00:00

abstract：:Total anomalous pulmonary venous return (TAPVR) is a congenital heart malformation that can be diagnosed in the fetus by indirect indicators on an echocardiogram, such as inability to demonstrate the pulmonary veins returning to the left atrium by color Doppler, the presence of a chamber or the pulmonary venous conflu...

journal_title：Fetal diagnosis and therapy

authors： Cormier CM,Kramer LA,Gupta-Malhotra M

更新日期：2010-01-01 00:00:00

abstract：:Microbial invasion and growth in amniotic fluid play an important role in infectious perinatal morbidity and mortality. In order to determine the influence of amniocentesis (ACT) on intra-amniotic infection development, we performed a study of 239 complete microbiological examinations of amniotic fluid specimens obtai...

journal_title：Fetal diagnosis and therapy

authors： Terzić MM,Plećas DV,Stimec BV,Petković SV

更新日期：1994-01-01 00:00:00

abstract：:A spontaneous intra-amniotic hemorrhage is a very rare condition, which has been previously described in symptomatic patients. We report a case of an asymptomatic spontaneous intra-amniotic hemorrhage at 38 weeks of gestation, resulting in a favorable maternal and neonatal outcome following sonographic antenatal detec...

journal_title：Fetal diagnosis and therapy

authors： Gilboa Y,Duvdevani N,Yinon Y,Achiron R

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the reproducibility of both a new contrast-enhancing technique (Oblique View eXtended Imaging, OVIX; Samsung) and the recently reported 3-D multiplanar technique (MPT) in the measurement of the subpubic angle (SPA) among a group of women at term gestation. In addition, we ...

journal_title：Fetal diagnosis and therapy

authors： Ghi T,Youssef A,Martelli F,Montaguti E,Krsmanovic J,Pacella G,Pilu G,Rizzo N,Gabrielli S

更新日期：2015-01-01 00:00:00

abstract：:Spontaneous preterm birth has enormous consequences for newborns, children, and families. Intra-amniotic inflammation (IAI) is the leading cause of spontaneous preterm delivery, mainly at earlier gestational ages. Amniocentesis is the only method used to identify IAI in clinical practice. Although it is an invasive pr...

journal_title：Fetal diagnosis and therapy

authors： Cobo T,Kacerovsky M,Jacobsson B

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:We investigated to see the effect of antibiotics on interleukin (IL)-6 and IL-8 in cervicovaginal fluid in patients with premature rupture of the membranes. STUDY DESIGN:Cervicovaginal fluid was sampled on admission and before delivery for measurement of IL-6 and IL-8 from 31 patients with less than 35 weeks...

journal_title：Fetal diagnosis and therapy

authors： Matsuda Y,Kouno S,Nakano H

更新日期：2002-07-01 00:00:00

abstract：:The process of monozygotic twinning in animals and humans is presented. In addition, congenital defects in monozygotic twins versus dizygotic twins and singletons is discussed. Overall, the rates of congenital anomalies are higher among whites as compared to blacks, males as compared to females, and multiples as compa...

journal_title：Fetal diagnosis and therapy

authors： Luke B,Keith LG

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Assessment of the dimensions of the cardiac chambers and the great arteries in the human fetus may be helpful in the prenatal diagnosis of congenital heart disease. The purpose of this prospective cross-sectional study was to compile normative data in fetal cardiac measurements in early pregnancy. The struct...

journal_title：Fetal diagnosis and therapy

authors： Gembruch U,Shi C,Smrcek JM

更新日期：2000-01-01 00:00:00

abstract：AIM:To establish normal ranges of maternal placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and sFlt-1/PlGF ratio at 32-41 weeks' gestation and to evaluate the influence of maternal characteristics, and of fetoplacental Doppler. MATERIAL AND METHODS:Serum levels of PlGF, sFlt-1 and sFlt-1/Pl...

journal_title：Fetal diagnosis and therapy

authors： Lobmaier SM,Figueras F,Mercade I,Crovetto F,Peguero A,Parra-Saavedra M,Ortiz JU,Crispi F,Gratacós E

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To describe the course of total and ionized magnesium and total calcium levels in maternal serum during low-risk pregnancies and to compare women who developed preterm labor and delivery with those who delivered at term. METHODS:209 women with low-risk pregnancies were enrolled in a prospective trial before...

journal_title：Fetal diagnosis and therapy

authors： Arikan GM,Panzitt T,Gücer F,Scholz HS,Reinisch S,Haas J,Weiss PA

更新日期：1999-11-01 00:00:00

abstract：:Congenital diaphragmatic hernia (CDH) and congenital pulmonary airway malformation (CPAM) are diseases in which chest-occupying lesions can result in severe pulmonary hypoplasia. However, significant postnatal mortality due to pulmonary hypertension (PH) is more often seen in patients with CDH. We analyzed prenatal ec...

journal_title：Fetal diagnosis and therapy

authors： Derderian SC,Jayme CM,Cheng LS,Keller RL,Moon-Grady AJ,MacKenzie TC

更新日期：2016-01-01 00:00:00