Cardiovascular and pulmonary effects of betamethasone during midtrimester on fetal rats.

Abstract:

:In order to elucidate the effects of corticosteroids on fetal hearts during midtrimester, pregnant rats were injected with a daily dose of betamethasone (1 mg/kg) from the 12th day through the 17th day of pregnancy. The fetal cardiovascular and pulmonary systems were studied on the 21st day of pregnancy (term). The treated fetuses showed the following signs of hydrops fetalis: retarded growth, pale, edematous skin, and decreased movement. The thymus and lung displayed prominent hypoplasia. The morphometry of the treated fetuses revealed: decreased right ventricle mass by 37% and decreased left ventricle mass by 29%. We concluded betamethasone had a significant effect on the developing fetal cardiovascular system, inducing hydrops fetalis. Additionally, beta-methasone caused hypoplasia of the thymus and lung.

journal_name

Fetal Diagn Ther

authors

Wu FF,Momma K,Takao A

doi

10.1159/000263754

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

89-94

issue

2

eissn

1015-3837

issn

1421-9964

journal_volume

8

pub_type

杂志文章
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    doi:10.1159/000020980

    authors: Hartung J,Chaoui R,Bollmann R

    更新日期:2000-03-01 00:00:00

  • The influence of smoking and parity on serum markers for Down's syndrome screening.

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    authors: Tislarić D,Brajenović-Milić B,Ristić S,Latin V,Zuvić-Butorac M,Bacić J,Petek M,Kapović M

    更新日期:2002-01-01 00:00:00

  • Liver position is a prenatal predictive factor of prosthetic repair in congenital diaphragmatic hernia.

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    doi:10.1159/000123611

    authors: Kunisaki SM,Barnewolt CE,Estroff JA,Nemes LP,Jennings RW,Wilson JM,Fauza DO

    更新日期:2008-01-01 00:00:00

  • Retrospective diagnosis of Pallister-Killian syndrome by CGH array.

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    authors: Delahaye A,Pipiras E,Delorme-Vincent C,Benkhalifa M,Kasakyan S,Devisme L,Wolf JP,Benzacken B

    更新日期:2006-01-01 00:00:00

  • Dysthymic reactions of women undergoing chorionic villus sampling for prenatal diagnosis of hemoglobinopathies or karyotyping.

    abstract:OBJECTIVES:The aim of the study was to investigate the levels of anxiety and depression, as well as liability to depression, of women undergoing chorionic villus sampling (CVS) due to the risk of giving birth to a child suffering from hemoglobinopathy, or trisomy. METHODS:The study population consisted of 309 women wh...

    journal_title:Fetal diagnosis and therapy

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    authors: Lykeridou K,Daskalakis G,Papadatou D,Vaslamatzis G,Dafni O,Antsaklis A

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  • Mathematical models for fetal growth: application for biparietal diameter measurement.

    abstract::Evaluation of the adequacy of fetal growth by measurements of fetal size required theoretical formulae for the assessment of present size from previous measurements. The various models presented in the literature assume the same mathematical formula for the whole pregnancy. In this study, a model of different polynomi...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263955

    authors: Nitzan M,Tadmor OP,Skomorowski Y,Rabinowitz R,Diamant Y

    更新日期:1994-09-01 00:00:00

  • Isolated fetal bilateral radial ray reduction associated with valproic acid usage.

    abstract::The authors describe the first case of an isolated bilateral radial ray reduction occurring in a fetus exposed in utero to valproic acid; the diagnosis was made by ultrasound during the second trimester. This case of an isolated radial ray reduction associated with valproic acid use in pregnancy is a reminder for sono...

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    pub_type: 杂志文章

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    authors: Langer B,Haddad J,Gasser B,Maubert M,Schlaeder G

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    abstract::We have analyzed morphometric measurements from midgestational fetal necropsies and shown that arm and foot lengths are linear relationships versus gestational age (GA). Using foot length as the GA determinant, we found that the ratio of arm:foot length was also a linear relationship and was decreased in trisomy 21 fe...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章

    doi:10.1159/000263920

    authors: Johnson MP,Michaelson JE,Barr M Jr,Treadwell MC,Isada NB,Dombrowski MP,Pryde PG,Addis J,Evans MI

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  • Prenatal Diagnosis of Dextrocardia with Complex Congenital Heart Disease Using Fetal Intelligent Navigation Echocardiography (FINE) and a Literature Review.

    abstract::Fetal dextrocardia is a type of cardiac malposition where the major axis from base to apex points to the right side. This condition is usually associated with a wide spectrum of complex cardiac defects. As a result, dextrocardia is conceptually difficult to understand and diagnose on prenatal ultrasound. The advantage...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000468929

    authors: Yeo L,Luewan S,Markush D,Gill N,Romero R

    更新日期:2018-01-01 00:00:00

  • Think of the Conus Medullaris at the Time of Diagnosis of Fetal Sacral Agenesis.

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    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000451080

    authors: Mottet N,Martinovic J,Baeza C,Guimiot F,Bault JP,Aubry MC,Riethmuller D,Zerah M,Cretolle C,Benachi A

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  • The role of echocardiography in the intraoperative management of the fetus undergoing myelomeningocele repair.

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    authors: Rychik J,Cohen D,Tran KM,Szwast A,Natarajan SS,Johnson MP,Moldenhauer JS,Khalek N,Martinez-Poyer J,Flake AW,Hedrick HL,Adzick NS

    更新日期:2015-01-01 00:00:00

  • Mass Effect Alone May Not Explain Pulmonary Vascular Pathology in Severe Congenital Diaphragmatic Hernia.

    abstract::Congenital diaphragmatic hernia (CDH) and congenital pulmonary airway malformation (CPAM) are diseases in which chest-occupying lesions can result in severe pulmonary hypoplasia. However, significant postnatal mortality due to pulmonary hypertension (PH) is more often seen in patients with CDH. We analyzed prenatal ec...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000434643

    authors: Derderian SC,Jayme CM,Cheng LS,Keller RL,Moon-Grady AJ,MacKenzie TC

    更新日期:2016-01-01 00:00:00

  • Cord Occlusion in Monochorionic Twins with Early Selective Intrauterine Growth Restriction and Abnormal Umbilical Artery Doppler: A Consecutive Series of 90 Cases.

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    pub_type: 杂志文章

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    authors: Parra-Cordero M,Bennasar M,Martínez JM,Eixarch E,Torres X,Gratacós E

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  • Beckwith-Wiedemann syndrome presenting with an elevated triple screen in the second trimester of pregnancy.

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    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000095837

    authors: Aagaard-Tillery KM,Buchbinder A,Boente MP,Ramin KD

    更新日期:2007-01-01 00:00:00

  • Increased nuchal translucency in a case of long-chain 3-hydroxyacyl- coenzyme A dehydrogenase deficiency.

    abstract::We present a case where the embryo showed an increased nuchal edema and a metabolic disorder. At 31 weeks of gestation the fetus developed a cardiomegaly and a hydrops. In this case, a long-chain 3-hydroxacyl-coenzyme A dehydrogenase deficiency (LCHAD deficiency) was confirmed by biochemical investigations in cultured...

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    pub_type: 杂志文章

    doi:10.1159/000021029

    authors: Tercanli S,Uyanik G,Hösli I,Cagdas A,Holzgreve W

    更新日期:2000-11-01 00:00:00

  • Is Cisterna Magna Width a Useful First-Trimester Marker of Aneuploidy?

    abstract:OBJECTIVE:To assess whether the cisterna magna (CM) width measured in first-trimester fetuses is a useful marker for aneuploidy detection. METHODS:This was a prospective study in 2 different cohorts in a tertiary referral center. The first cohort comprised 913 fetuses from the general pregnancy population during the p...

    journal_title:Fetal diagnosis and therapy

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    doi:10.1159/000503386

    authors: Pauta M,Grande M,Borobio V,Illanes C,Soler A,Nogué L,Borrell A

    更新日期:2020-01-01 00:00:00

  • Screening of fetal stem cells for infection and cytogenetic abnormalities.

    abstract::Fetal stem cell transplantation may rely on material from therapeutic abortions. It is essential that the stem cell transplant does not transmit any microorganisms that may affect the fetus and that genetically abnormal cells are avoided. To evaluate such contamination, human fetal stem cells collected February 1992 -...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264065

    authors: Ek S,Westgren M,Pschera H,Seiger A,Sundström E,Bui TH,Ringdén O

    更新日期:1994-11-01 00:00:00

  • Prenatal diagnosis of an epignathus associated with a 49,XXXXY karyotype--a case report.

    abstract:BACKGROUND:Epignathus is a rare form of congenital teratoma, originating from the base of the skull, most commonly the hard palate, or mandible. It has been associated with a poor prognosis due to complications including polyhydramnios and respiratory compromise at birth as a consequence of upper airway obstructions. I...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000160219

    authors: Staboulidou I,Miller K,Göhring G,Hillemanns P,Wüstemann M

    更新日期:2008-01-01 00:00:00

  • Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgery.

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    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000361021

    authors: Ridding G,Schluter PJ,Hyett JA,McLennan AC

    更新日期:2014-01-01 00:00:00

  • Thoraco-omphalopagus conjoined twins detected at as early as 9 weeks of gestation: transvaginal two-dimensional ultrasound, color Doppler and fetoplacental Doppler velocity waveform findings.

    abstract::Here we report a case of conjoined twins that were diagnosed antenatally by routine two-dimensional transvaginal ultrasound examination at as early as the 9th week of gestational age. The fetuses were of the thoraco-omphalopagus type and were sharing the liver, as confirmed by color Doppler. There was a reversed flow ...

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    authors: Basgül A,Kavak ZN,Sezen D,Basgul A,Gokaslan H

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    abstract::Congenital cardiac diverticula are transmural localized protrusions within the free wall of the ventricles. Right ventricular diverticula are rarely diagnosed during the fetal period, and due to their rarity, their natural history remains unclear. We present a case of prenatal diagnosis of right ventricular diverticul...

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  • New first-trimester crown-rump length equations from a French general population.

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    pub_type: 杂志文章

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    doi:10.1159/000020819

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    doi:10.1159/000346564

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