Dysthymic reactions of women undergoing chorionic villus sampling for prenatal diagnosis of hemoglobinopathies or karyotyping.

Abstract:

OBJECTIVES:The aim of the study was to investigate the levels of anxiety and depression, as well as liability to depression, of women undergoing chorionic villus sampling (CVS) due to the risk of giving birth to a child suffering from hemoglobinopathy, or trisomy. METHODS:The study population consisted of 309 women who attended the Fetal Medicine Unit of Alexandra Hospital, University of Athens, Athens, Greece for a first trimester chorionic villus sampling (CVS). One hundred and fifty-nine women (group A) underwent CVS due to increased possibility of carrying an embryo with beta-thalassemia, while 150 women had the procedure because of an increased nuchal translucency measurement, or a positive first trimester biochemical screening (group B). Three hundred and nine women, matched by age and gestational age with those of the study group, who were not subjected to any diagnostic intervention formed the control group. We further investigated differences of dysthymic reactions among three subgroups of women at risk for hemoglobinopathy: (a) women undergoing their first pregnancy; (b) women who had been pregnant more than once but had not any children, and (c) women who had given birth to at least one healthy child, irrespective of previous terminations. RESULTS:The incidence of clinically elevated levels of anxiety and depression was significantly higher in groups A and B compared to controls (p<0.001), while no significant difference was found in mean anxiety and depression, as well as the liability to depression among the three groups. Clinically elevated levels of depression were found in 10.1 and 4.7% of the women of the hemoglobinopathy and karyotyping group, respectively. Especially women who had no children, due to previous pregnancy terminations presented significantly higher incidence of elevated depression compared to women who were pregnant for the first time, or women who had given birth to at least one healthy child in their life. CONCLUSIONS:The findings of this study highlight the necessity of training medical and nursing personnel to understand and respond to the psychological and social needs of women undergoing CVS due to increased risk for hemoglobinopathy, and especially to those who have no children and who have a history of pregnancy termination due to an affected fetus.

journal_name

Fetal Diagn Ther

authors

Lykeridou K,Daskalakis G,Papadatou D,Vaslamatzis G,Dafni O,Antsaklis A

doi

10.1159/000075140

keywords:

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

149-54

issue

2

eissn

1015-3837

issn

1421-9964

pii

75140

journal_volume

19

pub_type

杂志文章
  • Increased nuchal translucency in a case of long-chain 3-hydroxyacyl- coenzyme A dehydrogenase deficiency.

    abstract::We present a case where the embryo showed an increased nuchal edema and a metabolic disorder. At 31 weeks of gestation the fetus developed a cardiomegaly and a hydrops. In this case, a long-chain 3-hydroxacyl-coenzyme A dehydrogenase deficiency (LCHAD deficiency) was confirmed by biochemical investigations in cultured...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000021029

    authors: Tercanli S,Uyanik G,Hösli I,Cagdas A,Holzgreve W

    更新日期:2000-11-01 00:00:00

  • Why cell culture is successful after early amniocentesis.

    abstract::The current interest in early amniocentesis as a possible alternative to chorion villus sampling has driven many centres to attempt cell culture from first trimester amniotic fluid. This study examines the cellular content of 125 amniotic fluid specimens collected between 8 and 18 weeks of gestation and shows that the...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263628

    authors: Byrne D,Azar G,Nicolaides K

    更新日期:1991-01-01 00:00:00

  • Pulmonary Vein Flow Impedance: An Early Predictor of Cardiac Dysfunction in Intrauterine Growth Restriction.

    abstract:INTRODUCTION:In intrauterine growth restriction (IUGR), increased uteroplacental vascular impedance contributes to preferential flow to left ventricle (LV), with consequent alteration of its compliance and increased left atrial (LA) pressure. Pulmonary vein pulsatility index (PVPI) reflects the increased impedance to L...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000488281

    authors: Bravo-Valenzuela NJM,Zielinsky P,Zurita-Peralta J,Nicoloso LH,Piccoli A Jr,Ferreira Van der Sand L,Miranda Sulis N,Carvalho Ritter C

    更新日期:2019-01-01 00:00:00

  • Thoraco-amniotic shunting.

    abstract::Thoraco-amniotic shunting was performed in 51 singleton pregnancies for decompression and chronic drainage of fetal pleural effusions (n = 47), pericardial effusion (n = 1), or pulmonary cysts (n = 3). Five fetuses had chromosomal defects and in 4 the parents elected termination of pregnancy. All 18 non-hydropic fetus...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000263586

    authors: Nicolaides KH,Azar GB

    更新日期:1990-01-01 00:00:00

  • Prenatal diagnosis of vein of Galen aneurysmal malformations.

    abstract::Vein of Galen aneurysmal malformations are rarely seen intracranial malformations. They represent less than 1% of the cerebral arteriovenous malformations. Prenatal diagnosis of an arteriovenous fistula malformation may be achieved by real-time and Doppler sonography with color flow imaging, by identifying dilated vei...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000073133

    authors: Paternoster DM,Manganelli F,Moroder W,Nicolini U

    更新日期:2003-11-01 00:00:00

  • Fetal responses to inadvertent contact with the needle during amniocentesis.

    abstract::Fetal responses in 7 cases of mid-trimester amniocentesis, complicated by inadvertent contact between the amniocentesis needle and fetal parts, were analyzed by retrospective videotape review. The incidence of inadvertent needle contact with the fetus was 0.4% (7 of 1,458). Responses included brisk withdrawal of the '...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264210

    authors: Petrikovsky BM,Kaplan GP

    更新日期:1995-03-01 00:00:00

  • Relationship between meconium staining and amniotic fluid volume in term pregnancies.

    abstract:OBJECTIVE:Our purpose was to evaluate the relationship between meconium-stained amniotic fluid (MEC-AF) and amniotic fluid volume (AFV) and their impact on the risk of cesarean delivery for fetal indications in term pregnancies. METHODS:1,655 live-born singleton gestations delivering at > or = 37 weeks within 7 days o...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000048013

    authors: Blackwell SC,Wolfe HM,Redman ME,Hassan SS,Berry SM,Treadwell MC,Zador I,Carreno CA,Sorokin Y

    更新日期:2002-03-01 00:00:00

  • Assessment of the risk of fetal loss after the coelocentesis procedure using a baboon model.

    abstract:OBJECTIVES:The aims of this study were to gain some insight with regard to the safety of the coelocentesis procedure and, to determine pH, pCO2, and base excess status of the extracoelomic fluid 40 days after fertilization. METHODS:Twenty-eight timed-mated baboons from the breeding colony of the Biological Resource La...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000020850

    authors: Santolaya-Forgas J,Vengalil S,Kushwaha A,Bieniarz A,Fortman J

    更新日期:1998-07-01 00:00:00

  • Echocardiographic risk stratification of fetuses with sacrococcygeal teratoma and twin-reversed arterial perfusion.

    abstract:OBJECTIVE:To evaluate pre-intervention echocardiographic parameters of cardiac function in fetuses who survive without hydrops as compared to fetuses who develop hydrops or perinatal death in the setting of sacrococcygeal teratoma (SCT) and twin-reversed arterial perfusion sequence (TRAP). METHODS:Clinical, echocardio...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000330762

    authors: Byrne FA,Lee H,Kipps AK,Brook MM,Moon-Grady AJ

    更新日期:2011-01-01 00:00:00

  • The influence of smoking and parity on serum markers for Down's syndrome screening.

    abstract:OBJECTIVE:To evaluate the impact of smoking and number of previous births on maternal serum levels of alpha-fetoprotein and free beta-subunit of human chorionic gonadotropin (free beta-hCG). METHODS:The study included 3,252 completed unaffected singleton pregnancies that proceeded beyond 37 weeks' gestation and result...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000047999

    authors: Tislarić D,Brajenović-Milić B,Ristić S,Latin V,Zuvić-Butorac M,Bacić J,Petek M,Kapović M

    更新日期:2002-01-01 00:00:00

  • First-trimester diagnosis of sirenomelia. A case report.

    abstract::We report a case of sirenomelia diagnosed at 13 gestational weeks. This rare malformation sequence is characterized by fusion and rotation of the lower limbs to various degrees and anorectal atresia, usually associated with absence of bladder and agenesis or dysgenesis of the kidneys. Diagnosis is commonly made later ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000053929

    authors: Carbillon L,Seince N,Largillière C,Bucourt M,Uzan M

    更新日期:2001-09-01 00:00:00

  • Successful management of intrauterine twin and concomitant cervical pregnancy: a case report.

    abstract::Use of in vitro fertilization techniques increases the frequency of pathological implantation. However, simultaneous pregnancies are a rarity. Ectopic implantation of the embryo may occur in the cervical canal. This is the first case report, which describes successful management of an intrauterine twin pregnancy which...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000089300

    authors: Ujvari E,Krizsa F,Sebestyen A,Varbiro S,Paulin F

    更新日期:2006-01-01 00:00:00

  • Prenatal Growth in Fetuses with Isolated Cyanotic and Non-Cyanotic Congenital Heart Defects.

    abstract:BACKGROUND:Fetal growth may vary significantly in different congenital heart defects (CHDs). OBJECTIVES:To investigate prenatal growth of CHD fetuses and its correlation with classifications based upon expected oxygen delivery to the fetal brain or structural findings. METHODS:Seventy-nine euploid fetuses with isolat...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000493938

    authors: Inversetti A,Fesslova V,Deprest J,Candiani M,Giorgione V,Cavoretto P

    更新日期:2020-01-01 00:00:00

  • Single umbilical artery: Does side matter?

    abstract:INTRODUCTION:The aim of this study was to determine if laterality of an absent umbilical artery (AUA) is associated with specific sonographic findings, chromosomal defects or postpartum birth defects. MATERIALS AND METHODS:In this retrospective cohort study, ultrasound reports and medical records of patients who recei...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000338133

    authors: Santillan M,Santillan D,Fleener D,Stegmann B,Zamba G,Hunter S,Yankowitz J

    更新日期:2012-01-01 00:00:00

  • Reported exposure to chickenpox: a predictor of positive anti-varicella-zoster antibodies in parturient women.

    abstract:OBJECTIVE:To determine the positive and negative predictive values of recalled exposure to chickenpox for identifying anti-varicella-zoster virus (VZV) seropositive parturient women. METHODS:Blood samples were taken from laboring women during February 1998: All women completed questionnaires concerning a history of ch...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000053952

    authors: Linder N,Ferber A,Kopilov U,Smetana Z,Barzilai A,Mendelson E,Sirota L

    更新日期:2001-11-01 00:00:00

  • Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgery.

    abstract:OBJECTIVE:To evaluate lower extremity neuromotor function (LENF) and short-term ambulatory potential following fetal myelomeningocele (fMMC) closure. METHODS:Retrospective chart review of 54 children that underwent fMMC closure at our institution prior to the NIHCD-MOMS trial. Neonatal LENF was compared to predicted f...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000197359

    authors: Danzer E,Gerdes M,Bebbington MW,Sutton LN,Melchionni J,Adzick NS,Wilson RD,Johnson MP

    更新日期:2009-01-01 00:00:00

  • Calprotectin in Serially Collected Meconium Portions as a Biomarker for Intrauterine Fetal Environment.

    abstract:OBJECTIVE:Understanding the pathomechanisms underlying high meconium calprotectin concentrations is the key to the potential uses of this parameter for the assessment of the intrauterine environment in which the fetus develops. The aim of this study was to measure calprotectin concentrations in serial meconium portions...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000472150

    authors: Lisowska-Myjak B,Skarżyńska E,Żytyńska-Daniluk J

    更新日期:2018-01-01 00:00:00

  • Soluble intercellular adhesion molecule 1 in umbilical cord serum: potential for the diagnosis of neonatal infections.

    abstract:OBJECTIVE:To evaluate the diagnostic relevance to neonatal infections of the soluble intercellular adhesion molecule 1 (sICAM-1) cord serum level. METHODS:The case-control study included 66 term newborn infants with and without risk factors for neonatal infections. Cord blood serum determinations of white blood cell c...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000048032

    authors: Daraï E,Poncelet C,Soriano D,Lejeune V,Bringuier AF,Madelenat P,Feldmann G,Scoazec JY

    更新日期:2002-05-01 00:00:00

  • Self-Amputation of the Extra Digit in a Fetus with Polydactyly: First Ultrasound Demonstration.

    abstract::We herein report the first ultrasound evidence of the self-amputation of an extra digit in case of fetal polydactyly. The prenatal evidence of fetal polydactyly is not always followed by postnatal confirmation. This is not always due to ultrasound misdiagnosis, but often to an in utero self-amputation phenomenon. We d...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000464462

    authors: Volpe N,Franchi L,Mazzone E,Migliavacca C,Raboni S,Percesepe A,Kaihura CT,Frusca T,Ghi T

    更新日期:2017-01-01 00:00:00

  • Ominous normalization of middle cerebral artery flow velocity waveforms preceding fetal death: case report.

    abstract::The loss of middle cerebral artery compensatory vasodilation appears to be ominous in fetuses with absent end-diastolic umbilical waveforms. The authors report a case with a loss of the 'brain-sparing effect' 24 h before fetal death. Current pathophysiological explanations are discussed. ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264215

    authors: Chitrit Y,Zorn B,Filidori M,Bucourt M,Chasseray JE,Caubel P

    更新日期:1995-03-01 00:00:00

  • Long-Term Outcome of Monochorionic Twins after Fetoscopic Laser Therapy Compared to Matched Dichorionic Twins.

    abstract:INTRODUCTION:The only causal therapy is fetoscopic laser surgery (FLS). The aims of this study were to analyze the long-term outcome of monochorionic twins treated by FLS, including their school career, need for therapy and special aid equipment, and free-time activities, and compare their outcome to matched dichorioni...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000509400

    authors: Rüegg L,Hüsler M,Krähenmann F,Zimmermann R,Natalucci G,Ochsenbein-Kölble N

    更新日期:2020-01-01 00:00:00

  • Perinatal outcome of monochorionic twins with selective intrauterine growth restriction and different types of umbilical artery Doppler under expectant management.

    abstract:OBJECTIVES:To evaluate the prognosis of monochorionic twins with selective intrauterine growth restriction (sIUGR), classified according to the type of umbilical artery Doppler, under expectant management. METHODS:The outcome of 81 cases with isolated sIUGR was evaluated according to a classification based on umbilica...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000253880

    authors: Ishii K,Murakoshi T,Takahashi Y,Shinno T,Matsushita M,Naruse H,Torii Y,Sumie M,Nakata M

    更新日期:2009-01-01 00:00:00

  • Perinatal outcome of conservative management versus fetal intervention for twin reversed arterial perfusion sequence with a small acardiac twin.

    abstract:OBJECTIVE:To examine the outcomes of patients with twin reversed arterial perfusion (TRAP) sequence in which the acardiac twin was

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000295176

    authors: Jelin E,Hirose S,Rand L,Curran P,Feldstein V,Guevara-Gallardo S,Jelin A,Gonzales K,Goldstein R,Lee H

    更新日期:2010-01-01 00:00:00

  • First trimester diagnosis of sirenomelia by 2D and 3D ultrasound.

    abstract::A case of sirenomelia in a 27-year-old woman detected at 11 weeks 5 days of gestation is presented. It was suspected by two-dimensional sonography and color Doppler imaging. Three-dimensional ultrasound confirmed the final diagnosis. With detailed evaluation of the acquired volumes, valuable information was obtained a...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000236359

    authors: Contu R,Zoppi MA,Axiana C,Ibba RM,Monni G

    更新日期:2009-01-01 00:00:00

  • Pre- and perinatal relations of hemophilia A and B.

    abstract:OBJECTIVE:The authors conducted a retrospective study of obstetric and genetic data, obstetric problems, and pregnancy outcome by investigating 149 pregnancies of patients who received genetic counselling because of hemophilia A or B over a 20-year period. METHODS:In cases with a heterozygous mother, fetal sex was det...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000066378

    authors: Beke A,Bán Z,Nagy B,Tóth-Pál E,Papp C,Csaba A,Papp Z

    更新日期:2003-01-01 00:00:00

  • Brain damage to the survivor within 30 min of co-twin demise in monochorionic twins.

    abstract::Single fetal death in a twin pregnancy in the late second or early third trimester is associated with significant morbidity and mortality rate in the surviving co-twin, especially in monochorionic twin pregnancies. The common causes are twin-to-twin transfusion syndrome, chromosomal abnormalities, and congenital anoma...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000082429

    authors: Karageyim Karsidag AY,Kars B,Dansuk R,Api O,Unal O,Turan MC,Goynumer G

    更新日期:2005-03-01 00:00:00

  • Neonatal leukemoid reaction and early development of bronchopulmonary dysplasia in a very low-birth-weight infant.

    abstract::The factors controlling the recruitment of inflammatory cells and the activation of the cytokine cascade in low-birth-weight premature infants have been implicated in the sequence of multiorgan inflammatory diseases, including the chronic lung disease of prematurity, bronchopulmonary dysplasia. This article describes ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000053900

    authors: Zanardo V,Magarotto M,Rosolen A

    更新日期:2001-05-01 00:00:00

  • Refining the Prediction and Prevention of Emergency Operative Deliveries with the Fetal Reserve Index.

    abstract::Electronic fetal monitoring (EFM) is a poor predictor of outcomes attributable to delivery problems. Contextualizing EFM by adding maternal, obstetrical, and fetal risk-related information to create an index called the Fetal Reserve Index (FRI) improves the predictive capacity and facilitates the timing of interventio...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000494617

    authors: Britt DW,Evans MI,Schifrin BS,Eden RD

    更新日期:2019-01-01 00:00:00

  • Prenatal diagnosis of lissencephaly by magnetic resonance image.

    abstract::Two cases of lissencephaly were prenatally diagnosed by a magnetic resonance image (MRI). Smooth surface of brain and remarkable sylvian fissure, which were barely detectable by ultrasound, were easily observed in MRI. MRI is the most appropriate tool in diagnosing lissencephaly. ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263748

    authors: Okamura K,Murotsuki J,Sakai T,Matsumoto K,Shirane R,Yajima A

    更新日期:1993-01-01 00:00:00

  • The Aortic Isthmus: A Significant yet Underexplored Watershed of the Fetal Circulation.

    abstract::The aortic isthmus (AoI) is a unique fetal watershed with a waveform reflecting its complex haemodynamic physiology. The systolic component represents left and right ventricular systolic ejection, and the diastolic component represents comparative downstream vascular impedance between the brachiocephalic and subdiaphr...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000446942

    authors: Tynan D,Alphonse J,Henry A,Welsh AW

    更新日期:2016-01-01 00:00:00