Abstract:
OBJECTIVE:The aim of this study was to assess the longterm efficacy, safety, and tolerability of risperidone, over a cumulative period of 3 years, in treating children with disruptive behaviour disorders and below average intelligence (IQ 35-84). METHOD:This trial included 35 children (aged 6-16 years), diagnosed with disruptive behaviour disorder. All subjects had previously completed a 1-year, open-label risperidone study, and this extension study followed them for an additional 2 years of treatment. Safety was assessed using the Extrapyramidal Symptom Rating Scale (ESRS), clinical laboratory tests, electrocardiograms, and the recording of adverse events, vital signs, Tanner score, and changes in body mass index (BMI). Efficacy was measured using the Clinical Global Impression of Severity (CGI-S) scale. RESULTS:The beneficial effects observed in the original trial were maintained during the extension. Few extrapyramidal side-effects occurred, as assessed by the ESRS, and there were no cases of tardive dyskinesia. The children showed a modest increase in BMI, part of which may be attributed to normal growth over the 2-year period. Most adverse events were mild or moderate in severity, and none of them were considered probably or very likely related to risperidone. CONCLUSION:Continuing low-dose risperidone for up to 3 years appears to be safe and effective in children with disruptive behaviour disorders.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Reyes M,Olah R,Csaba K,Augustyns I,Eerdekens Mdoi
10.1007/s00787-006-0504-0keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
97-104issue
2eissn
1018-8827issn
1435-165Xjournal_volume
15pub_type
临床试验,杂志文章,多中心研究abstract::Psychosocial problems during adolescence are heterogenic, rather common, and unstable. At the same time, they are associated with an elevated risk of developing psychiatric disorders later in life. We aimed to describe the trajectories of psychosocial problems during adolescence and examine potential markers of persis...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01321-9
更新日期:2019-12-01 00:00:00
abstract::Functional enuresis is a heterogeneous group of syndromes with different aetiology and pathophysiology. The aim was to identify specific somatic correlates of enuresis non-invasively in child psychiatric patients after exclusion of neurologic and structural forms of incontinence. One hundred sixty-seven consecutive ch...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870050092
更新日期:1999-06-01 00:00:00
abstract::While slow processing speed (PS) is well documented in youth with ADHD, growing evidence suggests that this difficulty affects children with other neuropsychiatric conditions. Clarifying the relationship between slow PS and different forms of psychopathology is important clinically, given the potential impact of PS on...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01455-w
更新日期:2020-10-01 00:00:00
abstract::Metabolic control in adolescents with diabetes is difficult to achieve and seems to depend in part on personality and the family environment. We tried to identify relevant characteristics in this study. We administered the Children's Manifest Anxiety Scale, a Self-Competence scale, a Locus of Control Scale, and a stru...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF02091790
更新日期:1992-04-01 00:00:00
abstract::Gender and sexually diverse adolescents have been reported to be at an elevated risk for suicidal thoughts and behaviors. For transgender adolescents, there has been variation in source of ascertainment and how suicidality was measured, including the time-frame (e.g., past 6 months, lifetime). In studies of clinic-ref...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01663-9
更新日期:2020-11-09 00:00:00
abstract::This study aims at determining serum levels of tryptophan and other metabolites of the kynurenine pathway in children with attention deficit hyperactivity disorder (ADHD) compared to healthy controls. Such metabolites interact with glutamate receptors in the central nervous system, potentially modulating mechanisms th...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-017-1002-2
更新日期:2017-12-01 00:00:00
abstract::This study investigates the prevalence and subtypes of conduct disorder (CD) and behavioral problems among youth in two communities characterized by prolonged parent-child separation upon immigration. CD and problem behaviors were assessed in 252 Caribbean-Canadian and Filipino-Canadian adolescents (12-19-year-old) us...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-007-0640-1
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:Based on the investigation of 144 families (144 patients affected by Multiple Sclerosis (MS), 109 partners, and 192 children) examined in three different European child and adolescent psychiatric University centres by means of questionnaires, we evaluated the prevalence of psychological symptoms in the offsp...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-006-0589-5
更新日期:2007-04-01 00:00:00
abstract::The aim of the investigation was to detect neuropsychological markers, such as sustained and selective attention and executive functions, which contribute to the vulnerability to schizophrenia especially in young persons. Performance was assessed in 32 siblings and children of schizophrenic patients and 32 matched con...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-006-0547-2
更新日期:2006-10-01 00:00:00
abstract::A crossover 'placebo'-controlled, double-blind design was used to examine the effectiveness of an oligoantigenic diet in 49 children with hyperactive/disruptive behavior disorder. Effects of diet were compared with those yielded by stimulant medication (methylphenidate). The study was conducted in an inpatient unit at...
journal_title:European child & adolescent psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00566671
更新日期:1997-06-01 00:00:00
abstract::Non-suicidal self-injury (NSSI) is a considerable health problem among adolescents. Affect regulation by means of self-injury may promote the maintenance of NSSI. However, existing findings have limited ecological validity. The present study aimed to assess emotional and interpersonal states preceding and following in...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01626-0
更新日期:2020-08-29 00:00:00
abstract::Parent-mediated intervention is widely used for pre-schoolers with autism spectrum disorder (ASD). Previous studies indicate small-to-moderate effects on social communication skills, but with a wide heterogeneity that requires further research. In this randomized controlled trial (RCT), cooperative parent-mediated the...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00787-019-01395-5
更新日期:2020-07-01 00:00:00
abstract::The cerebral effect of the loss of body weight in Anorexia nervosa (A.n.)--the so-called 'pseudoatrophy'-- is well known and confirmed by several neuroimaging studies. Another subject of intensive research has been whether A.n. leads to specific cognitive impairments, especially of intelligence. However, there are no ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870070005
更新日期:2000-01-01 00:00:00
abstract::In the adult population, psychiatric disorders are associated with somatic illness. Explanatory life style factors have been found, but also a failure to recognize somatic illness in this group. Another factor is side effects from long-term use of antipsychotic drugs. Given the psychiatric-somatic comorbidity in the a...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01313-9
更新日期:2019-11-01 00:00:00
abstract::Attention Deficit and Hyperactive Disorder (ADHD) and Autism Spectrum Disorders (ASD) are frequent comorbid neurodevelopmental conditions and the overlap between both disorders remains to be delineated. A more complete understanding of the shared genetic and environmental factors is needed. Using a family-based method...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-018-1206-0
更新日期:2019-02-01 00:00:00
abstract::Within the last decade, social anxiety disorder (SAD) has been identified as a highly prevalent and burdensome disorder. Both the characterization of its symptomatology and effective treatment options are widely documented. Studies particularly indicate that SAD aggregates in families and has its onset in early adoles...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-010-0138-0
更新日期:2010-12-01 00:00:00
abstract::The objective of this study is to compare the cognitive profile, the motor and language functioning and the psychosocial adaptation of children with Asperger syndrome (AS) and with high-functioning autism (HFA). Subjects were recruited through the department Autism and Developmental Disorders of the Heckscher-Klinikum...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-009-0057-0
更新日期:2010-06-01 00:00:00
abstract::Understanding the developmental course of all health issues associated with preterm birth is important from an individual, clinical and public health point-of-view. Both the number of preterm births and proportion of survivors have increased steadily in recent years. The UK Millennium Cohort Study (n = 18,818) was use...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-016-0872-z
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The Strengths and Difficulties Questionnaire (SDQ) is a short assessment instrument which addresses positive and negative behavioural attributes of children and adolescents and generates scores for clinically relevant aspects. Although this brief questionnaire has been widely used in Germany t...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-004-2002-6
更新日期:2004-01-01 00:00:00
abstract::DSM data are often used to build statistics on the types of patients to whom mental health services are offered. These statistics are normally based on broad categories that cluster finer subcategories for specific diagnoses. These broad categories can be built in a number of ways. The purpose of this study is to dete...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870070028
更新日期:2000-12-01 00:00:00
abstract::This is the first clinical description of a detailed psychological, speech, and language phenotype of four young children (< 5 years) with Velo-Cardio-Facial syndrome (VCFS) due to a deletion on chromosome 22 (22q11.2). The reported elevated risk of developing schizophrenia or bipolar disorder in adolescence for indiv...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870050005
更新日期:2000-06-01 00:00:00
abstract::The aim of this study is to investigate whether in addition to established early risk factors other, less studied pre-, peri-, and postnatal influences, like gestational hypertension or neonatal respiratory disorders and infections, may increase a child's risk of developing attention-deficit/hyperactivity disorders (A...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1007/s00787-017-0966-2
更新日期:2017-08-01 00:00:00
abstract::Conduct disorder (CD) is a common and highly impairing psychiatric disorder of childhood and adolescence that frequently leads to poor physical and mental health outcomes in adulthood. The prevalence of CD is substantially higher in males than females, and partly due to this, most research on this condition has used a...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-018-1172-6
更新日期:2018-09-01 00:00:00
abstract::The purpose of this study was to estimate the prevalence rates of probable posttraumatic stress disorder (PTSD) and depression and to explore potential risk factors among child and adolescent survivors 1 year following the 2008 Wenchuan earthquake. 3052 participants were administered the Child PTSD Symptom Scale, the ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-013-0400-3
更新日期:2013-09-01 00:00:00
abstract::The link between attention deficit/hyperactivity disorder (ADHD) and elevated body weight/obesity can be regarded as well established. Because oppositional defiant disorder (ODD)/conduct disorder (CD) has also been found to be associated with these characteristics and ADHD and ODD/CD often occur comorbidly, we investi...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-013-0489-4
更新日期:2014-07-01 00:00:00
abstract::Severe posttraumatic stress symptoms (PTSS) are connected to a variety of health-related and interpersonal problems, among them are the insecure attachment orientations. However, psychotherapy seems to improve not only PTSS but also attachment insecurities. In a large multicenter, randomized clinical trial, the attach...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01637-x
更新日期:2020-09-12 00:00:00
abstract::This study investigated the dietary restraint and depression pathway to loss of control over eating among a sample of overweight youngsters based on the assumptions of the extended cognitive behavioural theory for bulimia nervosa. The children's version of the eating disorder examination interview and the children's d...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-010-0089-5
更新日期:2010-07-01 00:00:00
abstract::Pediatric bipolar disorder (BD) and unipolar disorder (UD) share common symptomatic and functional impairments. Various brain imaging techniques have been used to investigate the integrity of brain white matter (WM) and gray matter (GM) in these disorders. Despite promising preliminary findings, it is still unclear wh...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-014-0614-z
更新日期:2014-11-01 00:00:00
abstract::Identifying early-onset schizophrenia spectrum disorders (SSD) at a very early stage remains challenging. To assess the diagnostic predictive value of multiple types of data at the emergence of early-onset first-episode psychosis (FEP), various support vector machine (SVM) classifiers were developed. The data were fro...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1007/s00787-014-0593-0
更新日期:2015-04-01 00:00:00
abstract::A Dutch translation of the Strengths and Difficulties Questionnaire (SDQ) was made. In the first wave of data collection, self-report data of 11- to 16-yearolds (N = 970) were collected on the SDQ and other measures of psychopathology. In the second wave of data collection, extended versions of the SDQ were completed ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-003-0341-3
更新日期:2003-12-01 00:00:00