Abstract：
:Macroscopic structural damage to the cartilage articular surface can occur due to slicing in surgery, cracking in mechanical trauma, or fibrillation in early stage osteoarthrosis. These alterations may render cartilage matrix and chondrocytes susceptible to subsequent mechanical injury and contribute to progression of degenerative disease. To examine this hypothesis, single 300 microm deep vertical slices were introduced across a diameter of the articular surface of osteochondral explant disks on day 6 after dissection. Then a single uniaxial unconfined ramp compression at 7 x 10(-5) or 7 x 10(-2) s(-1) strain rate to a peak stress of 3.5 or 14 MPa was applied on day 13 during which mechanical behavior was monitored. Effects of slices alone and together with compression were measured in terms of explant swelling and cell viability on days 10 and 17. Slicing alone induced tissue swelling without significant cell death, while compression alone induced cell death without significant tissue swelling. Under low strain rate loading, no differences in the response to injurious compression were found between sliced and unsliced explants. Under high strain rate loading, slicing rendered cartilage more easily compressible and appeared to slightly reduce compression-induced cell and matrix injury. Findings highlight microphysical factors important to cartilage mechanical injury, and suggest ways that macroscopic structural damage may accelerate or, in certain cases, possibly slow the progression of cartilage degeneration.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Morel V,Berutto C,Quinn TMdoi
10.1016/j.jbiomech.2005.01.026keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
924-30issue
5eissn
0021-9290issn
1873-2380pii
S0021-9290(05)00071-0journal_volume
39pub_type
杂志文章abstract：:Vessel geometry for numerical analysis is generally obtained by computed tomography (CT) or magnetic resonance imaging (MRI) and intravascular ultrasound (IVUS). Most medical imaging is obtained from patients for hemodynamic analysis due to the properties of vascular disease and the difficulties in angiography. To pre...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.04.003
更新日期：2012-06-01 00:00:00
abstract：:A technique is introduced for simultaneous measurements of the heel pad tissue deformation and the heel-ground contact stresses developing during the stance phase of gait. Subjects walked upon a gait platform integrating the contact pressure display optical method for plantar pressure measurements and a digital radiog...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(01)00143-9
更新日期：2001-12-01 00:00:00
abstract：:The unsteady flow through a model of the human nasal cavity is analyzed at a Strouhal number of Sr=0.791 for the complete respiration cycle. A comparison of the essential flow structures in the model geometry and a real nasal cavity shows the relevance of the model data. The analysis of the steady and unsteady solutio...
journal_title：Journal of biomechanics
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更新日期：2010-04-19 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.08.020
更新日期：2018-10-26 00:00:00
abstract：:Pulsatile flow in abdominal aortic aneurysm (AAA) models has been examined in order to understand the hemodynamics that may contribute to growth of an AAA. The model studies were conducted by experiments (flow visualization and laser Doppler velocimetry) and by numerical simulation using physiologically realistic rest...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(99)00134-7
更新日期：1999-12-01 00:00:00
abstract：:In the present study, the role of mitogen-activated protein kinases (MAPKs) in chondrocyte mechanotransduction was investigated. We hypothesized that MAPKs participate in fluid flow-induced chondrocyte mechanotransduction. To test our hypothesis, we studied cultured chondrocytes subjected to a well-defined mechanical ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(99)00176-1
更新日期：2000-01-01 00:00:00
abstract：:Increased knee flexion during stance is a common gait deviation in the child with cerebral palsy (CP), with distal hamstring lengthening surgeries being an accepted course of treatment. Post-operatively, improvements in gait kinematics have been reported, however little change is noted in the patterns of muscle activi...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbiomech.2007.01.001
更新日期：2007-01-01 00:00:00
abstract：:The literature contains many measurements of the fatigue properties of compact bone, but these experimental results have been difficult to interpret and use due to a large amount of apparent scatter: variation in the number of cycles to failure for a given cyclic stress or strain range. Recently Taylor (1998a, Journal...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(99)00112-8
更新日期：1999-11-01 00:00:00
abstract：:In this article, the tensile properties of gastric wall were investigated by using biomechanical test and theoretical analysis. The samples of porcine stomach strips from smaller and greater curvature of the stomach were cut in longitudinal and circumferential direction, respectively. The loading-unloading, stress rel...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.12.048
更新日期：2015-02-26 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.11.005
更新日期：2013-01-04 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(87)90039-x
更新日期：1987-01-01 00:00:00
abstract：:Increased practice difficulty during asymmetrical split-belt treadmill rehabilitation has been shown to improve gait outcomes during retention and transfer tests. However, research in this area has been limited by manual treadmill operation. In the case of variable practice, which requires stride-by-stride changes to ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.11.017
更新日期：2016-01-04 00:00:00
abstract：:The material properties of articular cartilage in the rabbit tibial plateau were determined using biphasic indentation creep tests. Cartilage specimens from matched-pair hind limbs of rabbits approximately 4 months of age and greater than 12 months of age were tested on two locations within each compartment using a cu...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.07.017
更新日期：2006-01-01 00:00:00
abstract：:Detecting and assessing an individual's gait can be important for medical diagnostic purposes and for developing and guiding follow-on rehabilitation protocols. Thus, an accurate, objective gait classification system has the potential to facilitate earlier diagnosis and improved clinical decision-making. Systems using...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbiomech.2019.06.009
更新日期：2019-08-27 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(83)90076-3
更新日期：1983-01-01 00:00:00
abstract：:Eight experienced male cyclists (C), eight well-trained male runners (R), and eight less-trained male noncyclists (LT) were tested under multiple cadence and power output conditions to determine: (1) if the cadence at which lower extremity net joint moments are minimized (cost function cadence) was associated with pre...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(99)00155-4
更新日期：2000-02-01 00:00:00
abstract：:Radiostereometric analysis (RSA) has become one of the recommended techniques for pre-market evaluation of new joint implant designs. In this study we evaluated the effect of repositioning of X-ray tubes and phantom model on the precision of the RSA method. In precision measurements, we utilized mean error of rigid bo...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2003.09.004
更新日期：2004-04-01 00:00:00
abstract：:The purpose of the study was to establish the link between the saddle vertical force and its determinants in order to establish the strategies that could trigger the sit-stand transition. We hypothesized that the minimum saddle vertical force would be a critical parameter influencing the sit-stand transition during cy...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.07.035
更新日期：2015-09-18 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.01.032
更新日期：2018-04-11 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2006.05.010
更新日期：2007-01-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.01.040
更新日期：2015-04-13 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章,评审
doi：10.1016/j.jbiomech.2010.10.021
更新日期：2011-01-11 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.05.017
更新日期：2016-07-05 00:00:00
abstract：:A series of 33 human femoral bones have been subjected to a four point bending test at high strain rates. Two different failure modes were recognized. A Y shaped fracture at the middle region induced by a pure bending moment yielded a zone of non-linearity at the load vs deformation curve and a higher bending force, m...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(86)90021-7
更新日期：1986-01-01 00:00:00
abstract：:Bilateral asymmetry in gallop stride limb contact patterns of four Quarter Horse fillies was documented by high-speed cinematography. Horses were filmed with rider by two cameras simultaneously while galloping along a straightaway. Even though signaled for each gallop lead an equivalent number of times, horses frequen...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(87)90285-5
更新日期：1987-01-01 00:00:00
abstract：:The healing of wounds is a complex process and the contraction of the resulting scar can have a negative impact on the neighbouring skin. A finite element model of skin simulating the contraction of a scar and deformation of the surrounding skin is presented. The skin is represented by an orthotropic-viscoelastic cons...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.02.024
更新日期：2008-01-01 00:00:00
abstract：:A novel technique to measure in vitro disc pressures in human cervical spine specimens was developed. A miniature pressure transducer was used and an insertion technique was designed to minimise artefacts due to insertion. The technique was used to measure the intradiscal pressure in cervical spines loaded in pure axi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(00)00205-0
更新日期：2001-04-01 00:00:00
abstract：:We studied the mechanical and anatomical anisotropy of the canine diaphragmatic central tendon (CT). Dumb-bell-shaped strips with effective dimensions of 10 x 2 mm (length x width) were cut from different regions of the canine diaphragmatic CT in two different orientations relative to the direction of neighboring musc...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(91)90289-y
更新日期：1991-01-01 00:00:00
abstract：:Computer simulation of human masticatory dynamics requires specification of the jaw's mass properties. These are difficult to estimate, especially in living subjects. Here, we used calibrated computed tomography (CT) to determine the properties of eight osseous jaw specimens with adult dentitions. When the CT numbers ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(02)00057-x
更新日期：2002-07-01 00:00:00
abstract：:Human cortical bone fracture toughness depends on the anatomical locations under quasi-static loading. Recent results also showed that under fall-like loading, cortical bone fracture toughness is similar at different anatomical locations in the same donor. While cortical bone toughening mechanisms are known to be depe...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.01.008
更新日期：2019-03-06 00:00:00
