The perfect storm: Torsades de Pointes in a child with leukemia.

abstract：BACKGROUND:Positron emission tomography (PET) and gallium scans facilitate diagnosis and staging, evaluation of response to therapy, and monitoring for relapse in Hodgkin lymphoma (HL), but have not been compared in pediatric HL. PROCEDURE:We performed concurrent PET and gallium scans on 44 pediatric HL patients at di...

journal_title：Pediatric blood & cancer

authors： Hines-Thomas M,Kaste SC,Hudson MM,Howard SC,Liu WA,Wu J,Kun LE,Shulkin BL,Krasin MJ,Metzger ML

更新日期：2008-08-01 00:00:00

abstract：:The BRAF V600E missense mutation is known to be present in a subset of central nervous system tumors. We report a patient with a BRAF V600E mutated pilomyxoid astrocytoma who failed multiple conventional chemotherapy regimens. Treatment with vemurafenib, a molecularly targeted therapy against the mutant BRAF V600E kin...

journal_title：Pediatric blood & cancer

authors： Skrypek M,Foreman N,Guillaume D,Moertel C

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:The Kids ITP Tools (KIT) is a disease-specific measure of health-related quality of life for children with immune thrombocytopenia (ITP). To facilitate use in international trials it has been cross-culturally adapted for France, Germany, the United Kingdom and Uruguay. This study assessed the validity and re...

journal_title：Pediatric blood & cancer

authors： Klaassen RJ,Blanchette V,Burke TA,Wakefield C,Grainger JD,Gaedicke G,Riedlinger A,Dufort G,Citrin E,Reguerre Y,Pellier I,Curtis C,Young NL

更新日期：2013-01-01 00:00:00

abstract：:We report three cases of hemophagocytic lymphohistiocytosis (HLH) in infants within the first 6 weeks of life. Diagnosis of HLH was made early after symptoms started. All three cases were successfully treated with dexamethasone and none relapsed, indicating that not all cases of HLH in very young infants are familial....

journal_title：Pediatric blood & cancer

authors： Tanoshima R,Takahashi H,Hokosaki T,Yamaguchi K,Goto S,Kai S

更新日期：2009-01-01 00:00:00

abstract：:Ovarian tumors have a low incidence in childhood, accounting for 1% of malignancies within the ages of 0-17 years. Small cell carcinoma of the ovary is a rare histology and historically has a poor prognosis. We report a case of an 11-year-old female diagnosed with small cell carcinoma of the ovary and hypercalcemia (S...

journal_title：Pediatric blood & cancer

authors： Martinez-Borges AR,Petty JK,Hurt G,Stribling JT,Press JZ,Castellino SM

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Adolescents with cancer report a strong desire to be actively involved in personal healthcare decision making. The purpose of this study was to examine adolescent cancer patients' involvement in conversations about relapsed and refractory disease, to characterize the content of patient-clinician communicatio...

journal_title：Pediatric blood & cancer

authors： Frederick NN,Mack JW

更新日期：2018-04-01 00:00:00

abstract：:This is the case report of a 14-year young female who was diagnosed with solitary bone plasmacytoma (SBP) of proximal tibia and was treated by local involved field radiotherapy. We present the clinical, radiological and pathological findings of the case and review of the available treatment options and prognosis of th...

journal_title：Pediatric blood & cancer

authors： Kumar P,Sharma SC,Saikia UN,Kumar N,Vyas S,Angurana SL

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Malnutrition is a pro-inflammatory state, yet data on nutritional risk factors and development of acute graft-versus-host disease (aGVHD) are extremely limited. PROCEDURE:We conducted a retrospective cohort analysis of pediatric patients up to age 21 years who underwent allogeneic hematopoietic stem cell tr...

journal_title：Pediatric blood & cancer

authors： Kerby EH,Li Y,Getz KD,Smith EC,Smith LT,Bunin NJ,Seif AE

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Thyroid dysfunction has been reported in up to 52% of patients 1.4 years after treatment with (131) I-Metaiodobenzylguanidine (MIBG) in children with neuroblastoma (NBL), despite the use of potassium-iodide (KI). Our aim was to investigate if the incidence and severity of thyroid damage increases in time. M...

journal_title：Pediatric blood & cancer

authors： Clement SC,van Eck-Smit BL,van Trotsenburg AS,Kremer LC,Tytgat GA,van Santen HM

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Although intra-retinal tumor has long been staged presurgically according to the Reese-Ellsworth (R-E) system, retinoblastoma differs from other pediatric neoplasms in never having had a widely accepted classification system that encompasses the entire spectrum of the disease. Comparisons among studies that ...

journal_title：Pediatric blood & cancer

authors： Chantada G,Doz F,Antoneli CB,Grundy R,Clare Stannard FF,Dunkel IJ,Grabowski E,Leal-Leal C,Rodríguez-Galindo C,Schvartzman E,Popovic MB,Kremens B,Meadows AT,Zucker JM

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Thrombosis in neonates is a rare but serious occurrence, usually associated with central catheterization. The objective of this study was to investigate the risk factors associated with catheter related thrombosis in very low birth weight (VLBW) infants. PROCEDURE:The present retrospective study was perform...

journal_title：Pediatric blood & cancer

authors： Narang S,Roy J,Stevens TP,Butler-O'Hara M,Mullen CA,D'Angio CT

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Glucocorticoids and asparaginase, used to treat acute lymphoblastic leukemia (ALL), can cause hypertriglyceridemia. We compared triglyceride levels, risk factors, and associated toxicities in two ALL trials at St. Jude Children's Research Hospital with identical glucocorticoid regimens, but different asparag...

journal_title：Pediatric blood & cancer

authors： Finch ER,Smith CA,Yang W,Liu Y,Kornegay NM,Panetta JC,Crews KR,Molinelli AR,Cheng C,Pei D,Ramsey LB,Karol SE,Inaba H,Sandlund JT,Metzger M,Evans WE,Jeha S,Pui CH,Relling MV

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Image-guided percutaneous core needle biopsy (PCNB) is increasingly utilized to diagnose solid tumors. The objective of this study is to determine whether PCNB is adequate for modern biologic characterization of neuroblastoma. PROCEDURE:A multi-institutional retrospective study was performed by the Pediatri...

journal_title：Pediatric blood & cancer

authors： Overman RE,Kartal TT,Cunningham AJ,Fialkowski EA,Naik-Mathuria BJ,Vasudevan SA,Malek MM,Kalsi R,Le HD,Stafford LC,Lautz TB,Many BT,Jones RE,Bütter A,Davidson J,Williams A,Dasgupta R,Lewis J,Troutt M,Aldrink JH,Man

更新日期：2020-05-01 00:00:00

abstract：:We evaluated the effects of body mass index (BMI) on the risk of thromboembolism (TE) in children (<18 years) with hematological malignancies during the period 1990-2009 (n = 359). Obesity was prevalent in 12% of patients: 6% versus 17% prior to and after the year 2000 (P = 0.02). Sixty-one (17%) patients developed TE...

journal_title：Pediatric blood & cancer

authors： Tuckuviene R,Christensen AL,Chan AK,Athale U

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Despite advances in therapy, outcome in many high-grade pediatric central nervous system (CNS) tumors remains poor. The focus of neuro-oncology research has thus turned towards identifying novel therapeutic targets. Poly(ADP-ribose) polymerase-1 (PARP1) is a DNA repair protein that has been studied in a vari...

journal_title：Pediatric blood & cancer

authors： Barton VN,Donson AM,Kleinschmidt-DeMasters BK,Gore L,Liu AK,Foreman NK

更新日期：2009-12-15 00:00:00

abstract：:The commonly accepted definition of Fanconi anemia (FA) relying on DNA repair deficiency is submitted to a critical review starting from the early reports pointing to mitomycin C bioactivation and to the toxicity mechanisms of diepoxybutane and a group of nitrogen mustards causing DNA crosslinks in FA cells. A critica...

journal_title：Pediatric blood & cancer

authors： Pagano G,d'Ischia M,Pallardó FV

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:We wanted to ascertain patterns of recurrence, re-treatment, and outcome among 188 eligible patients treated for localized orbital sarcoma on IRSG Protocols III/IV, 1984-1997. PROCEDURE:Retrospective chart review. RESULTS:Twenty-four of 188 patients (12.8%) developed local (n = 22) or distant relapse (n = ...

journal_title：Pediatric blood & cancer

authors： Raney B,Huh W,Hawkins D,Hayes-Jordan A,Million L,Rodeberg D,Teot L,Anderson J,Soft Tissue Sarcoma Committee of the Children's Oncology Group, Arcadia, CA.

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Pediatric oncology patients with tunneled central venous catheters (CVCs) are at increased risk to develop venous thromboembolic events (VTEs), but the true prevalence of (a)symptomatic VTE is unknown. Aim of this study was to evaluate the prevalence of (a)symptomatic VTE in pediatric oncology patients with ...

journal_title：Pediatric blood & cancer

authors： Schoot RA,van de Wetering MD,Stijnen T,Tissing WJ,Michiels E,Abbink FC,Raphael MF,Heij HA,Zwaan M,Lieverst JA,Caron HN,van Ommen H,DCOG-Aristocaths Supportive Care Working Group.

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Hematopoietic stem cell transplant (HSCT) can cure or alleviate a wide range of nonmalignant childhood conditions. However, few studies have examined longitudinal national trends of frequency or short-term complications of HSCT before 2006 when an HSCT became a reportable procedure by US law. By using a US n...

journal_title：Pediatric blood & cancer

authors： Takahashi T,Pereda MA,Bala N,Nagarajan S

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PHT) may be the leading cause of death in β-thalassemia patients; however, its pathophysiologic mechanisms are still unclear. Recent studies indicate that asymmetric dimethylarginine (ADMA) plays a role in the initiation and progression of a variety of diseases, especially the cardiov...

journal_title：Pediatric blood & cancer

authors： Mohamed el-S,Ibrahim B,Amr D,Noha el-K,Mokhtar M

更新日期：2014-09-01 00:00:00

abstract：:We describe five cases of children who completed chemotherapy for infantile acute lymphoblastic leukemia (ALL) and soon after were diagnosed with severe T-cell, non-HIV immunodeficiency, with varying B-cell and NK-cell depletion. There was near absence of CD3(+) , CD4(+) , and CD8(+) cells. All patients developed mult...

journal_title：Pediatric blood & cancer

authors： Geerlinks AV,Issekutz T,Wahlstrom JT,Sullivan KE,Cowan MJ,Dvorak CC,Fernandez CV

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Advanced irradiation techniques, including intensity-modulated radiation therapy (IMRT), aim to limit irradiation to adjoining tissues by conforming beams to a well-defined volume. In intracranial germinomas, whole-ventricular IMRT decreases the volume of irradiation to surrounding parenchyma. This study exa...

journal_title：Pediatric blood & cancer

authors： Toll SA,Jones MT,Yoshida EJ,Dhall G,Olch AJ,Wong KK

更新日期：2019-12-01 00:00:00

abstract：:The provision of tele-practice symptom management is often without the provision of evidence-based guidelines. Under the auspices of the Pediatric Oncology Group of Ontario, a nursing task force was established to appraise the evidence and develop guidelines. Promising new efforts to enhance symptom management through...

journal_title：Pediatric blood & cancer

authors： Tsimicalis A,De Courcy MJ,Di Monte B,Armstrong C,Bambury P,Constantin J,Dagelman B,Eves M,Jansen P,Honeyford L,Stregger D,Pediatric Oncology Group of Ontario.

更新日期：2011-10-01 00:00:00

abstract：:Beckwith-Wiedemann syndrome (BWS) is a genetic overgrowth and cancer predisposition syndrome, associated with both benign and malignant adrenal findings. Literature review and an institutional case series elucidate the wide spectrum of adrenal findings in BWS patients. The altered expression of the 11p15 region is lik...

journal_title：Pediatric blood & cancer

authors： MacFarland SP,Mostoufi-Moab S,Zelley K,Mattei PA,States LJ,Bhatti TR,Duffy KA,Brodeur GM,Kalish JM

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Sickle cell anaemia (SCA) is the leading genetic disorder in Nigeria. Elevated velocities ≥170 cm/sec occur in about a third of Nigerian children with SCA. Chronic blood transfusion for stroke prevention is faced with a myriad of challenges in our practice. OBJECTIVES:To evaluate the effectiveness of hydrox...

journal_title：Pediatric blood & cancer

authors： Lagunju I,Brown BJ,Sodeinde O

更新日期：2015-09-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a rare disease in children. Different from that in adults, childhood CML involves transformative events occurring over a short time period. CML transformation to lymphoid blast phase (BP) is associated with copy number abnormalities, characteristic of BCR-ABL1 positive acute lymphobla...

journal_title：Pediatric blood & cancer

authors： Klumb CE,Barbosa TDC,Nestal de Moraes G,Schramm MT,Emerenciano M,Maia RC

更新日期：2019-04-01 00:00:00

abstract：:Unstable hemoglobin variants represent a rare etiology of congenital hemolytic anemia. Without a high index of suspicion, plus proper laboratory testing and interpretation, the correct diagnosis can be elusive. We report on five children who were initially thought to have other congenital disorders such as hereditary ...

journal_title：Pediatric blood & cancer

authors： Yates AM,Mortier NA,Hyde KS,Hankins JS,Ware RE

更新日期：2010-12-15 00:00:00

abstract：BACKGROUND:This study was conducted to evaluate oral health and dental anomalies in children treated for acute lymphoblastic leukemia (ALL) and to compare results with those of a group of healthy children matched for sex and age. PROCEDURE:Fifty-six children treated for ALL and 56 healthy controls were examined for de...

journal_title：Pediatric blood & cancer

authors： Maciel JC,de Castro CG Jr,Brunetto AL,Di Leone LP,da Silveira HE

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Symptoms of epidural compression (SEC) in children with neuroblastoma (particularly infants) may be misinterpreted, leading to delay in diagnosis. PATIENTS AND METHODS:Clinical, imaging and follow-up data of 34 infants with neuroblastoma and SEC diagnosed between 2000 and 2011 at Italian AIEOP centers were ...

journal_title：Pediatric blood & cancer

authors： De Bernardi B,Quaglietta L,Haupt R,Castellano A,Tirtei E,Luksch R,Mastrangelo S,Viscardi E,Indolfi P,Cellini M,Tamburini A,Erminio G,Gandolfo C,Sorrentino S,Vetrella S,Gigliotti AR

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND AIM:We reviewed the results and pattern of failure of the consensus HB/HCC 1996 treatment protocol for pediatric hepatoblastoma (HB) in Hong Kong. The role of SIOPEL and Children's Hepatic tumors International Collaboration (CHIC) risk stratification was evaluated. METHODS:Patients enrolled on the proto...

journal_title：Pediatric blood & cancer

authors： Liu APY,Ip JJK,Leung AWK,Luk CW,Li CH,Ho KKH,Lo R,Chan EKW,Chan ACY,Chung PHY,Chiang AKS

更新日期：2019-01-01 00:00:00