Docetaxel in ovarian cancer.

abstract：INTRODUCTION:Moderate-to-severe AD burdens a large proportion of AD patients and may represent an inadequacy of treatment options available for resistant disease. AREAS COVERED:This review provides an overview of the therapies for moderate-to-severe AD in late-stage development and in the clinic, and focuses on barici...

journal_title：Expert opinion on pharmacotherapy

authors： Mendes JT,Balogh EA,Strowd LC,Feldman SR

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a chronic, inflammatory disease afflicting 2% of the US population; it results in significant morbidity. The annual healthcare costs related to psoriasis are an estimated $11.3 billion and, with an expanding biologic market, an updated costs analysis is needed. AREAS COVERED:Current treatment...

journal_title：Expert opinion on pharmacotherapy

authors： Staidle JP,Dabade TS,Feldman SR

更新日期：2011-09-01 00:00:00

abstract：:Following Huggins' original observation of the dependence of the prostate on androgens, testosterone suppression by either orchiectomy or oestrogen compounds (e.g., diethylstilbesterol [DES]) became the standard palliative treatment for advanced prostate cancer. Early studies showed testosterone suppression improved s...

journal_title：Expert opinion on pharmacotherapy

authors： Perez-Marrero R,Tyler RC

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:Vertigo and dizziness are common chief complaints of vestibular and ocular motor disorders (lifetime prevalence 30%). Treatment relies on physical, pharmacological, psychological and rarely surgical approaches. Eight groups of drugs are currently used in vestibular and ocular motor disorders, namely anti-v...

journal_title：Expert opinion on pharmacotherapy

authors： Zwergal A,Strupp M,Brandt T

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease is thought to be caused by increased formations of neurotoxic amyloid beta (A beta) peptides, which give rise to the hallmark amyloid plaques. Therefore, pharmacological agents that reduce A beta formation may be of therapeutic benefit. OBJECTIVE:This paper reviews the pharmacology and c...

journal_title：Expert opinion on pharmacotherapy

authors： Henley DB,May PC,Dean RA,Siemers ER

更新日期：2009-07-01 00:00:00

abstract：INTRODUCTION:Loss of bone mineral density is an emerging problem in persons living with HIV infection. Earlier and more rapid bone demineralization has been attributed not only to the high prevalence of traditional risk factors, but also to specific HIV-related factors. The aim of this guidance is to stimulate an appro...

journal_title：Expert opinion on pharmacotherapy

authors： Negredo E,Bonjoch A,Clotet B

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Hepatitis C virus (HCV) therapy continues to evolve rapidly. ABT-450 is a novel potent inhibitor of the non-structural 3/4A protease that has been studied in combination with several agents, allowing shorter duration of therapy and interferon-free/ribavirin-free all-oral regimens. Preliminary data from stu...

journal_title：Expert opinion on pharmacotherapy

authors： Carrion AF,Gutierrez J,Martin P

更新日期：2014-04-01 00:00:00

abstract：:There is accumulating evidence that tumour necrosis factor (TNF) plays a major role in the pathogenesis of rheumatoid arthritis (RA). Recent biotechnological advances have allowed for the development of agents that directly target TNF, a pro-inflammatory cytokine. In the last 2 years, the US FDA and the EU's Commissio...

journal_title：Expert opinion on pharmacotherapy

authors： Mikuls TR,Moreland LW

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:Postpartum depression (PPD) is a common and serious illness that affects up to 14% of women in the first month after childbirth. We present an update on the pharmacologic treatment of PPD, although there continues to be a lack of large, randomized controlled trials (RCTs). AREAS COVERED:A review of the li...

journal_title：Expert opinion on pharmacotherapy

authors： Kim DR,Epperson CN,Weiss AR,Wisner KL

更新日期：2014-06-01 00:00:00

abstract：:Consensus guidelines for the management of HIV infection recommend the use of two nucleoside analogues in combination with either a non-nucleoside reverse transcriptase inhibitor or a ritonavir-boosted protease inhibitor in therapy-naive patients. As adherence is crucial for treatment success, regimens with fewer pill...

journal_title：Expert opinion on pharmacotherapy

authors： Waters L,Moyle G

更新日期：2006-12-01 00:00:00

abstract：:Anorexia is a frequent complication of uraemic syndrome, which contributes to malnutrition in dialysis patients. Uraemic anorexia has been associated with many factors. This paper reviews the current knowledge about mechanisms responsible for uraemic anorexia, the treatments and new drugs used to control the loss of a...

journal_title：Expert opinion on pharmacotherapy

authors： Aguilera A,Selgas R,Diéz JJ,Bajo MA,Codoceo R,Alvarez V

更新日期：2001-11-01 00:00:00

abstract：INTRODUCTION:Bronchodilators represent the mainstay of symptomatic treatment for chronic obstructive pulmonary disease (COPD). The principal bronchodilator agents are β(2)-agonists, anticholinergics and methylxanthines, used singly or in combination. Indacaterol is a novel long-acting β(2)-agonist for maintenance bronc...

journal_title：Expert opinion on pharmacotherapy

authors： Steiropoulos P,Papanas N,Nena E,Bouros D

更新日期：2012-05-01 00:00:00

abstract：:Colesevelam HCl (WelChol, Sankyo Pharmaceuticals Inc.) is a bile acid sequestrant polymer, which has been shown to significantly lower low density lipoprotein cholesterol and favourably affect high-density lipoprotein cholesterol blood levels in monotherapy and in combination with statins (HMG-CoA reductase inhibitors...

journal_title：Expert opinion on pharmacotherapy

authors： Bays H,Dujovne C

更新日期：2003-05-01 00:00:00

abstract：:ABSTARCT Introduction: Cardiovascular disease (CVD) continues to be an essential cause of morbidity and mortality among people living with human immunodeficiency virus infection (PLWH). Since the bulk of cardiovascular risk (CVR) factors are shared between PLWH and the general population, prevention and treatment stra...

journal_title：Expert opinion on pharmacotherapy

authors： Corbacho N,Mur I,Molas ME,Vidal F,Domingo P

更新日期：2021-01-04 00:00:00

abstract：:An increasing need for economic evaluations of non-Hodgkin's lymphoma (NHL) treatments exists. We performed a literature review on the currently available NHL economic evaluations, using PubMed and the Cochrane database. English and Dutch language papers on treatment in adults were selected. A total of 88 publications...

journal_title：Expert opinion on pharmacotherapy

authors： van Agthoven M,Uyl-de Groot CA,Sonneveld P,Hagenbeek A

更新日期：2004-12-01 00:00:00

abstract：INTRODUCTION:Graves' hyperthyroidism is associated with significant morbidity and mortality risk. The thionamides, methimazole, its pro-drug derivative carbimazole, and propylthiouracil, remain a cornerstone of management. Yet despite decades of use, optimal strategies for maximising treatment response and curtailing a...

journal_title：Expert opinion on pharmacotherapy

authors： Okosieme OE,Lazarus JH

更新日期：2016-10-01 00:00:00

abstract：:The availability of antiretroviral therapy has significantly reduced the morbidity and mortality of HIV infection. In addition, improved treatment of opportunistic infections and comorbidities common to patients with HIV is further prolonging the lives of patients. Improvement in the treatment of HIV has led to a sign...

journal_title：Expert opinion on pharmacotherapy

authors： Robertson SM,Penzak SR,Pau AK

更新日期：2005-02-01 00:00:00

abstract：:Thirty to forty percent of patients with idiopathic membranous nephropathy have persistent heavy proteinuria and may progress to end-stage kidney disease in 5 - 15 years. The ideal treatment for these patients is a matter of debate. Several nonspecific immunosuppressive regimens have been suggested with the aim of red...

journal_title：Expert opinion on pharmacotherapy

authors： Ruggenenti P,Cravedi P,Remuzzi G

更新日期：2007-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic, autoimmune disease that has traditionally been treated with non-biologic and biologic disease-modifying antirheumatic drugs (DMARDs). Although these agents have become firmly established as effective RA treatments, some patients do not have an adequate response. The recent appro...

journal_title：Expert opinion on pharmacotherapy

authors： Lundquist LM

更新日期：2007-10-01 00:00:00

abstract：:Poor therapeutic adherence is a major issue faced by physicians today. This paper summarizes the adherence rates with oral bisphosphonate (OBP) treatment in clinical practice and their impact on clinical outcomes. Studies systematically demonstrated that overall compliance and persistence with OBPs among osteoporotic ...

journal_title：Expert opinion on pharmacotherapy

authors： Rabenda V,Hiligsmann M,Reginster JY

更新日期：2009-10-01 00:00:00

abstract：:A systemic and endemic emerging mycosis in Latin America, paracoccidioidomycosis, is characterised by its chronicity and by the severity of the disseminated form in healthy individuals, as well as in immunocompromised individuals co-infected with HIV, resulting, in the latter, in a mortality rate in the range of 30 - ...

journal_title：Expert opinion on pharmacotherapy

authors： Yasuda MA

更新日期：2005-03-01 00:00:00

abstract：INTRODUCTION:Panic disorder (PD) is a prevalent psychiatric disorder characterized by unexpected and recurrent panic attacks. PD patients present significant psychosocial impairment and a high risk of psychiatric comorbidities and suicide. PD should be treated effectively as soon as the symptoms emerge because the long...

journal_title：Expert opinion on pharmacotherapy

authors： Freire RC,Hallak JE,Crippa JA,Nardi AE

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Silodosin is a new uroselective alpha-blocker with high pharmacological selectivity for the (1A) adrenoceptor. It is an effective and well-tolerated treatment in men with lower urinary tract symptoms (LUTS), due to presumed bladder outlet obstruction secondary to benign prostatic hyperplasia (BPH). The eff...

journal_title：Expert opinion on pharmacotherapy

authors： Osman NI,Chapple CR,Cruz F,Desgrandchamps F,Llorente C,Montorsi F

更新日期：2012-10-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Most guidelines suggest that failure of oral antidiabetic drugs should be followed by the addition of a basal insulin with aggressive titration of the dose. In most countries, neutral protamine Hagedorn (NPH)-insulin, glargine and detemir are the only choices. Clinical trials show that the metab...

journal_title：Expert opinion on pharmacotherapy

authors： Jensen MG,Hansen M,Brock B,Rungby J

更新日期：2010-08-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Hypertension is a major independent risk factor for kidney disease and for faster renal function loss. Choice of antihypertensive strategies with highest nephroprotective effect is crucial to prevent or reverse progression to end stage renal disease (ESRD). AREAS COVERED IN THIS REVIEW:The pres...

journal_title：Expert opinion on pharmacotherapy

authors： Cravedi P,Ruggenenti P,Remuzzi G

更新日期：2010-11-01 00:00:00

abstract：:Chronic kidney diseases frequently advance to end-stage renal failure, and the number of patients affected is steadily increasing worldwide. At the molecular level, progression of renal insufficiency correlates closely with ongoing pathological matrix protein expansion (i.e., renal fibrosis), in a manner independent o...

journal_title：Expert opinion on pharmacotherapy

authors： Gaedeke J,Neumayer HH,Peters H

更新日期：2006-03-01 00:00:00

abstract：:Candesartan is a long-acting angiotensin receptor antagonist that is well absorbed from the gastrointestinal tract, with insurmountable receptor binding abilities. Recent studies have shown candesartan to be an effective therapy for heart failure patients, producing a significant reduction in mortality and morbidity. ...

journal_title：Expert opinion on pharmacotherapy

authors： McKelvie RS

更新日期：2006-10-01 00:00:00

abstract：INTRODUCTION:Benign prostate hyperplasia (BPH) is one of the most prevalent diseases in aging men. It may adversely affect quality-of-life due to the presence of low urinary tract symptoms (LUTS) and its effects on sexuality. AREAS COVERED:The impact of α1-blockers, 5α-reductase inhibitors (5-ARI), and phosphodiestera...

journal_title：Expert opinion on pharmacotherapy

authors： La Vignera S,Aversa A,Cannarella R,Condorelli RA,Duca Y,Russo GI,Calogero AE

更新日期：2020-09-09 00:00:00

abstract：INTRODUCTION:The pharmacotherapeutic management of depression in patients with multiple sclerosis (MS) is a matter of debate that cannot be decided from the evidence available in the current literature. Therefore, its management essentially relies on the clinical experience of the prescribing clinician rather than on e...

journal_title：Expert opinion on pharmacotherapy

authors： Carta MG,Paribello P,Anastasia A,De Berardis D,Nardi AE,Fornaro M

更新日期：2018-10-01 00:00:00

abstract：:One of the most significant advances of the last decade has been the development of platelet glycoprotein (GP) IIb/IIIa receptor inhibitors. A large series of randomised, controlled clinical trials of these agents have shown a significant reduction in ischaemic events, not only in acute coronary syndrome patients, but...

journal_title：Expert opinion on pharmacotherapy

authors： Anne G,Gruberg L

更新日期：2004-02-01 00:00:00