Reassuring fetal middle cerebral artery doppler velocimetry in alloimmunised pregnancies: neonatal outcomes without invasive procedures.

Abstract:

OBJECTIVE:To assess the neonatal outcome in red blood cell alloimmunised pregnancies at increased risk of fetal anaemia where invasive testing was avoided based on reassuring middle cerebral artery (MCA) Doppler velocity results. METHODS:We included 28 alloimmunised pregnant women at significant risk of fetal or neonatal anaemia who did not have invasive testing because of reassuring MCA Doppler velocimetry. Women requiring invasive testing or intrauterine transfusion were excluded. Outcome measures were admission to neonatal intensive care unit, cord haemoglobin and bilirubin levels and neonatal therapy. RESULTS:Ten neonates (36%) were anaemic at birth while 18 (64%) had normal haemoglobin. Seven neonates (25%) did not require any form of neonatal therapy, 10 (36%) had phototherapy only, 7 (25%) required exchange transfusions and 4 (14%) top-up transfusions. There were no treatment-related complications. Mean cord haemoglobin was 13.9 g/dl (range 7-18.9) and mean bilirubin was 84.1 micromol/l (range 29-192). CONCLUSION:Avoiding invasive procedures in pregnancies at risk of fetal anaemia by relying on reassuring MCA Doppler velocimetry did not result in life-threatening fetal or neonatal morbidities. The extent of neonatal therapy was acceptable. The routine use of this test can lead to less unnecessary invasive procedures in at-risk fetuses.

journal_name

Fetal Diagn Ther

authors

Abdel-Fattah SA,Shefras J,Kyle PM,Cairns P,Hunter A,Soothill PW

doi

10.1159/000086809

keywords:

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

341-5

issue

5

eissn

1015-3837

issn

1421-9964

pii

86809

journal_volume

20

pub_type

临床试验,杂志文章
  • Cardiovascular and pulmonary effects of betamethasone during midtrimester on fetal rats.

    abstract::In order to elucidate the effects of corticosteroids on fetal hearts during midtrimester, pregnant rats were injected with a daily dose of betamethasone (1 mg/kg) from the 12th day through the 17th day of pregnancy. The fetal cardiovascular and pulmonary systems were studied on the 21st day of pregnancy (term). The tr...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263754

    authors: Wu FF,Momma K,Takao A

    更新日期:1993-03-01 00:00:00

  • Changes in the approach for invasive prenatal diagnosis in 35,127 cases at a single center from 1977 to 2004.

    abstract:OBJECTIVES:To evaluate the changes in the approaches used for invasive prenatal diagnosis for beta-thalassemia and karyotyping at a single center from 1977 to 2004. METHODS:For beta-thalassemia, in 1977 placentacentesis, in 1982 amniocentesis, in 1983 fetoscopy and cordocentesis, in 1983 trancervical chorionic villi s...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000092464

    authors: Monni G,Zoppi MA,Axiana C,Ibba RM

    更新日期:2006-01-01 00:00:00

  • Fetal cardiovascular physiology and therapy.

    abstract::The ability to diagnose fetal cardiovascular malformations prenatally has been established during the past 14 years. This has naturally led to an increased interest in the possibility of providing timely therapy in the neonatal period and has raised the prospects for prenatal intervention. Before medical, catheter, an...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000263663

    authors: Kleinman CS,Copel JA

    更新日期:1992-01-01 00:00:00

  • Clinical and Economic Impact of Adopting Noninvasive Prenatal Testing as a Primary Screening Method for Fetal Aneuploidies in the General Pregnancy Population.

    abstract:OBJECTIVE:To evaluate the clinical and economic impact of adopting noninvasive prenatal testing (NIPT) using circulating cell-free DNA as a first-line screening method for trisomy 21, 18, and 13 in the general pregnancy population. METHODS:A decision-analytical model was developed to assess the impact of adopting NIPT...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000491750

    authors: Kostenko E,Chantraine F,Vandeweyer K,Schmid M,Lefevre A,Hertz D,Zelle L,Bartha JL,Di Renzo GC

    更新日期:2019-01-01 00:00:00

  • Recurrent septo-optic dysplasia accompanied by omphalocele: a case report.

    abstract::Septo-optic dysplasia, also known as de Morsier syndrome, is a rare congenital entity almost always characterized by hypoplasia/dysplasia of the optical nerve, chiasma or optic radiations and the complete or partial absence of the septum pellucidum. It may also be accompanied by other malformations, including multiple...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000207450

    authors: Tanrikulu F,Korucuoglu U,Efeturk T,Yildirim FD,Biri A

    更新日期:2009-01-01 00:00:00

  • Maternal mortality following diagnostic 2nd-trimester amniocentesis.

    abstract::We present 2 cases of maternal mortality after transabdominal amniocentesis performed during the 2nd trimester of pregnancy. In both these cases, blood cultures revealed Escherichia coli. Broad-spectrum intravenous antibiotic treatment started immediately after admission to the hospital did not change the rapid progre...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000075150

    authors: Elchalal U,Shachar IB,Peleg D,Schenker JG

    更新日期:2004-03-01 00:00:00

  • A retrospective and theoretical evaluation of rapid methods for detecting chromosome abnormalities and their implications on genetic counseling based on a series of 3868 CVS diagnoses.

    abstract:OBJECTIVES:To report our experience over the past 10 years of chorionic villi sampling (CVS) prenatal diagnosis in a high-risk population for chromosomal anomalies, and to analyze, according to the results, the advantages and disadvantages of using quantitative fluorescence polymerase chain reaction (QF-PCR) in amnioti...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000111592

    authors: Soler A,Morales C,Badenas C,Rodríguez-Revenga L,Carrió A,Margarit E,Costa D,Borrell A,Goncé A,Milà M,Sánchez A

    更新日期:2008-01-01 00:00:00

  • Screening for placental insufficiency by transvaginal uterine artery Doppler at 22-24 weeks of gestation.

    abstract:OBJECTIVE:To determine the value of routine transvaginal color Doppler assessment of the uterine arteries at 22-24 weeks of gestation in the prediction of placental insufficiency. METHODS:Women with singleton pregnancies scheduled for routine ultrasound scans at 22-24 weeks were offered Doppler assessment of the uteri...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章

    doi:10.1159/000178141

    authors: Palma-Dias RS,Fonseca MM,Brietzke E,Fritsch A,Schlatter D,Maurmann CB,Stein NR,Magalhães JA

    更新日期:2008-01-01 00:00:00

  • Subpubic Arch Angle and Mode of Delivery in Low-Risk Nulliparous Women.

    abstract:OBJECTIVE:To assess whether subpubic arch angle (SPA) measurement before labor onset can predict labor outcome among low-risk pregnant women. METHODS:3D ultrasound volume was transperineally acquired from a series of nulliparous women with uncomplicated pregnancy at term before the onset of labor. SPA was measured off...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000441517

    authors: Youssef A,Ghi T,Martelli F,Montaguti E,Salsi G,Bellussi F,Pilu G,Rizzo N

    更新日期:2016-01-01 00:00:00

  • Maternal serum vitamin D at 11-13 weeks in pregnancies delivering small for gestational age neonates.

    abstract:OBJECTIVES:To determine if maternal serum levels of 25(OH)D at 11-13 weeks' gestation are altered in pregnancies that subsequently deliver small for gestational age (SGA) neonates and whether the levels are related to placental function reflected in serum concentration of pregnancy-associated plasma protein-A (PAPP-A)....

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000333810

    authors: Ertl R,Yu CK,Samaha R,Akolekar R,Nicolaides KH

    更新日期:2012-01-01 00:00:00

  • Fetoscopic laser photocoagulation of feeding vessels to a large placental chorioangioma following fetal deterioration after amnioreduction.

    abstract::Large placental chorioangiomas (>4 cm) can precipitate severe polyhydramnios, fetal anemia, growth restriction, high-output cardiac failure, hydrops, and fetal demise. We report a case of a large chorioangioma that was treated in a stepwise fashion with amnioreduction to ameliorate maternal discomfort, followed by fet...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000331944

    authors: Jones K,Tierney K,Grubbs BH,Pruetz JD,Detterich J,Chmait RH

    更新日期:2012-01-01 00:00:00

  • Antibodies to trophoblast antigens HLA-G, placenta growth factor, and neuroD2 do not improve detection of circulating trophoblast cells in maternal blood.

    abstract:OBJECTIVES:Non-invasive prenatal diagnosis using circulating fetal trophoblast cells has been challenging due to lack of a reproducible trophoblast-specific antibody. We investigated the use of three trophoblast cell-specific antibodies, HLA-G, placenta growth factor, and neuroD2, for the isolation of trophoblast cells...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000097102

    authors: Tjoa ML,Delli-Bovi L,Johnson KL,Bianchi DW

    更新日期:2007-01-01 00:00:00

  • Large hepatic mesenchymal hamartoma leading to mid-trimester fetal demise.

    abstract::This report describes a fetus with a large multiloculated cystic liver mass. Two small abdominal cysts were seen on ultrasound at 19 weeks of gestation but the patient was referred to us at 23 weeks, after the mass had grown to 8.0 x 5.6 x 7.0 cm, displacing intra-abdominal organs, heart and diaphragm. There was a sma...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000082439

    authors: Laberge JM,Patenaude Y,Desilets V,Cartier L,Khalife S,Jutras L,Chen MF

    更新日期:2005-03-01 00:00:00

  • Role of ultrasonography in pregnancies with marker chromosome aneuploidy.

    abstract::The objective of this report was to evaluate the effect of ultrasonographic (US) findings on pregnancy management in patients with marker chromosome (MC) aneuploidy ascertained through prenatal diagnosis. From 1989 through June 1993, 15,522 prenatal diagnostic procedures were performed for accepted indications. Charts...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264230

    authors: Hume RF Jr,Drugan A,Ebrahim SA,Johnson MP,Isada NB,Reichler A,Evans MI

    更新日期:1995-05-01 00:00:00

  • Fetal longitudinal myocardial function assessment by anatomic M-mode.

    abstract:AIM:To evaluate the feasibility of offline anatomic M-mode (AMM) to study fetal atrioventricular annulus long-axis displacement (LAD) and compare its performance against real-time conventional M-mode (MM). MATERIAL AND METHODS:Paired AMM and MM LAD studies were recorded prospectively in 54 fetuses, and performance was...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000330790

    authors: Germanakis I,Pepes S,Sifakis S,Gardiner H

    更新日期:2012-01-01 00:00:00

  • Prenatal diagnosis of lissencephaly by magnetic resonance image.

    abstract::Two cases of lissencephaly were prenatally diagnosed by a magnetic resonance image (MRI). Smooth surface of brain and remarkable sylvian fissure, which were barely detectable by ultrasound, were easily observed in MRI. MRI is the most appropriate tool in diagnosing lissencephaly. ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263748

    authors: Okamura K,Murotsuki J,Sakai T,Matsumoto K,Shirane R,Yajima A

    更新日期:1993-01-01 00:00:00

  • Meconium Peritonitis: Correlation of Antenatal Diagnosis and Postnatal Outcome - An Institutional Experience over 10 Years.

    abstract:OBJECTIVE:To identify the fetal and neonatal imaging characteristics of meconium peritonitis (MP) and their clinical outcome. We also studied the role of prenatal ultrasound (US) in antenatal diagnosis and its use in predicting the need for surgical intervention postnatally. MATERIAL AND METHODS:We conducted a retrosp...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000449380

    authors: Ping LM,Rajadurai VS,Saffari SE,Chandran S

    更新日期:2017-01-01 00:00:00

  • Mid-trimester thoracoamniotic shunting for the treatment of fetal primary pleural effusions in a twin pregnancy. a case report.

    abstract::Thoracoamniotic shunting has been described as having a beneficial role in the antenatal management of primary pleural effusions in singleton pregnancies. We report a case of a twin pregnancy in which progressive pleural effusions and hydrops were diagnosed in one of the fetuses at 16 weeks of gestation. An initial ev...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000021007

    authors: Grisaru-Granovsky S,Seaward PG,Windrim R,Wyatt P,Kelly EN,Ryan G

    更新日期:2000-07-01 00:00:00

  • Fetal responses to inadvertent contact with the needle during amniocentesis.

    abstract::Fetal responses in 7 cases of mid-trimester amniocentesis, complicated by inadvertent contact between the amniocentesis needle and fetal parts, were analyzed by retrospective videotape review. The incidence of inadvertent needle contact with the fetus was 0.4% (7 of 1,458). Responses included brisk withdrawal of the '...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264210

    authors: Petrikovsky BM,Kaplan GP

    更新日期:1995-03-01 00:00:00

  • Fetoscopic endotracheal occlusion for severe isolated diaphragmatic hernia: initial experience from a single clinic in Brazil.

    abstract:OBJECTIVE:To report on the initial experience in a single Brazilian university clinic of the use of fetoscopic endotracheal occlusion (FETO) to treat severe isolated congenital diaphragmatic hernia (CDH). METHODS:The inclusion criteria for FETO for this prospective study were isolated CDH and intrathoracic herniation ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000314617

    authors: Peralta CF,Sbragia L,Bennini JR,de Fátima Assunção Braga A,Sampaio Rousselet M,Machado Rosa IR,Barini R

    更新日期:2011-01-01 00:00:00

  • Uterine artery pulsatility index assessment at 11-13 weeks' gestation.

    abstract:INTRODUCTION:First-trimester uterine artery pulsatility index (PI) measurements form part of an algorithm used to assess the risk of developing pre-eclampsia. The objective of this study was to construct a population-specific reference range for both the lower and mean maternal uterine artery PI at 11-13(+6) weeks' ges...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000361021

    authors: Ridding G,Schluter PJ,Hyett JA,McLennan AC

    更新日期:2014-01-01 00:00:00

  • Congenital laryngeal cyst: benefits of prenatal diagnosis and multidisciplinary perinatal management.

    abstract::Congenital laryngeal cysts are rare and can cause upper airway obstruction if they are misdiagnosed. We describe a case of large vallecular cyst diagnosed at 33 weeks of gestation. The purpose of an early diagnosis is to establish a careful perinatal management. If the airway is compromised, a multidisciplinary medica...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000077969

    authors: Busuttil M,Einaudi MA,Hassid S,Chau C,Shojai R,Thomachot L,D'Ercole C,Gire C

    更新日期:2004-07-01 00:00:00

  • Noninvasive Sampling of the Intrauterine Environment in Women with Preterm Labor and Intact Membranes.

    abstract::Spontaneous preterm birth has enormous consequences for newborns, children, and families. Intra-amniotic inflammation (IAI) is the leading cause of spontaneous preterm delivery, mainly at earlier gestational ages. Amniocentesis is the only method used to identify IAI in clinical practice. Although it is an invasive pr...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000480232

    authors: Cobo T,Kacerovsky M,Jacobsson B

    更新日期:2018-01-01 00:00:00

  • Chorioamniotic membrane separation following open fetal surgery: pregnancy outcome.

    abstract:OBJECTIVE:To review the incidence of posthysterotomy chorioamniotic membrane separation and delivery outcome following open fetal surgery [myelomeningocele (MMC); cystic adenomatoid malformation (CCAM); congenital diaphragmatic hernia (CDH); sacrococcygeal teratoma (SCT)]. STUDY DESIGN:Retrospective review of a matern...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000071972

    authors: Wilson RD,Johnson MP,Crombleholme TM,Flake AW,Hedrick HL,King M,Howell LJ,Adzick NS

    更新日期:2003-09-01 00:00:00

  • The role of echocardiography in the intraoperative management of the fetus undergoing myelomeningocele repair.

    abstract:INTRODUCTION:Fetal surgery for myelomeningocele (MMC) results in better outcomes compared to postnatal treatment. However, risks are present. We describe our experience with intraoperative fetal echocardiography during repair of MMC and report on the management of serious cardiovascular events. MATERIAL AND METHODS:Th...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000364863

    authors: Rychik J,Cohen D,Tran KM,Szwast A,Natarajan SS,Johnson MP,Moldenhauer JS,Khalek N,Martinez-Poyer J,Flake AW,Hedrick HL,Adzick NS

    更新日期:2015-01-01 00:00:00

  • Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes.

    abstract:BACKGROUND:To improve neonatal outcomes in pregnancies at heightened risk for early-onset neonatal sepsis (EONS), there is a need to identify fetuses that benefit from expectant management as opposed to early delivery. Detectable haptoglobin and haptoglobin-related protein (Hp&HpRP switch-on status) in cord blood has b...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000450997

    authors: Archabald KL,Buhimschi IA,Bahtiyar MO,Dulay AT,Abdel-Razeq SS,Pettker CM,Lipkind HS,Hardy JT,McCarthy ME,Zhao G,Bhandari V,Buhimschi CS

    更新日期:2017-01-01 00:00:00

  • Single umbilical artery: Does side matter?

    abstract:INTRODUCTION:The aim of this study was to determine if laterality of an absent umbilical artery (AUA) is associated with specific sonographic findings, chromosomal defects or postpartum birth defects. MATERIALS AND METHODS:In this retrospective cohort study, ultrasound reports and medical records of patients who recei...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000338133

    authors: Santillan M,Santillan D,Fleener D,Stegmann B,Zamba G,Hunter S,Yankowitz J

    更新日期:2012-01-01 00:00:00

  • Circulating mRNA for the PLAC1 gene as a second trimester marker (14-18 weeks' gestation) in the screening for late preeclampsia.

    abstract:OBJECTIVE:To develop a model for prediction of late preeclampsia (PE; which develops at or after 34 weeks' gestation) based on maternal history and characteristics, mean arterial pressure (MAP), and circulating levels of mRNA for the placenta-specific 1 (PLAC1) gene in maternal plasma at 14-18 weeks' gestation. METHOD...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000360854

    authors: Zanello M,Sekizawa A,Purwosunu Y,Curti A,Farina A

    更新日期:2014-01-01 00:00:00

  • Detection of DeltaF508del using quantitative real-time PCR, comparison of the results obtained by fluorescent PCR.

    abstract:OBJECTIVE:Cystic fibrosis (CF) is the most common autosomal recessive genetic disorder in the Caucasian population. The molecular diagnosis is difficult since there are about 1,000 mutations in the CF transmembrane regulator gene. The DeltaF508del is the cause of the CF in 64% of the cases in Hungary. Our aim was to co...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000095846

    authors: Nagy B,Nagy GR,Lázár L,Bán Z,Papp Z

    更新日期:2007-01-01 00:00:00

  • Retrospective diagnosis of Pallister-Killian syndrome by CGH array.

    abstract:OBJECTIVE AND METHODS:We report a girl presenting with a polymalformation syndrome. Despite a normal karyotype on peripheral lymphocytes and the unavailability of cultured fibroblasts, a tetrasomy 12p was identified on pulmonary DNA extracted from a postmortem biopsy, by use of comparative genomic hybridization (CGH) a...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000095658

    authors: Delahaye A,Pipiras E,Delorme-Vincent C,Benkhalifa M,Kasakyan S,Devisme L,Wolf JP,Benzacken B

    更新日期:2006-01-01 00:00:00