Differential expression of striatal synaptotagmin mRNA isoforms in hemiparkinsonian rats.

abstract：:Rapid changes in the light-dark cycle cause circadian desynchronization between rhythms of spike-wave discharges (SWDs) and motor activity in genetic epileptic rats, and this is accompanied by an increase in epileptic activity. Given the close relationship between absence seizures and sleep-wake states, the present st...

journal_title：Neuroscience

authors： Smyk MK,van Luijtelaar G,Huysmans H,Drinkenburg WH

更新日期：2019-06-01 00:00:00

abstract：:Differential vulnerability in the hindbrain neurons was examined immunohistochemically during hindbrain ischemia in the gerbil. Hindbrain ischemia was produced by extracranial occlusion of the bilateral vertebral arteries just before their entry into the transverse foramen of the cervical vertebra. Local cerebral bloo...

journal_title：Neuroscience

authors： Hata R,Matsumoto M,Hatakeyama T,Ohtsuki T,Handa N,Niinobe M,Mikoshiba K,Sakaki S,Nishimura T,Yanagihara T

更新日期：1993-09-01 00:00:00

abstract：:We have examined the effects of low pH and the selectivity of the capsaicin antagonist capsazepine on single sensory fibres innervating the guinea-pig trachea in vitro, and on the whole isolated vagus nerve. Application of a pH 5 solution for 1 min to the exposed receptive fields of single fibres caused excitation of ...

journal_title：Neuroscience

authors： Fox AJ,Urban L,Barnes PJ,Dray A

更新日期：1995-08-01 00:00:00

abstract：:Dopamine in the prefrontal cortex plays a critical role in normal cognition throughout the lifespan and has been implicated in the pathophysiology of neuropsychiatric disorders such as schizophrenia and attention deficit disorder. Little is known, however, about the postnatal development of the dopaminergic system in ...

journal_title：Neuroscience

authors： Weickert CS,Webster MJ,Gondipalli P,Rothmond D,Fatula RJ,Herman MM,Kleinman JE,Akil M

更新日期：2007-02-09 00:00:00

abstract：:The localization of GABAA receptors was studied by immunohistochemistry in the nucleus tractus solitarii of the rat using a monoclonal antibody (bd17) against the beta-subunit. The pattern of distribution was compared with that of GABA-immunoreactive axons and nerve terminals. Positive staining for GABAA receptors was...

journal_title：Neuroscience

authors： Terai K,Tooyama I,Kimura H

更新日期：1998-02-01 00:00:00

abstract：:The cellular mechanisms underlying the genesis of thalamic ponto-geniculo-occipital waves were studied in reserpinized cats under urethane anaesthesia. Simultaneous field potential and intracellular recordings were performed in the lateral geniculate nucleus after acute lesions of retinal and visual cortical inputs. I...

journal_title：Neuroscience

authors： Hu B,Steriade M,Deschênes M

更新日期：1989-01-01 00:00:00

abstract：:We have generated and characterized a multi-functional polyclonal anti-brain-derived neurotrophic factor antibody. Western blot analysis, dorsal root ganglion neurite outgrowth and dorsal root ganglion neuron survival assays showed that this antibody specifically recognized brain-derived neurotrophic factor and not th...

journal_title：Neuroscience

authors： Yan Q,Rosenfeld RD,Matheson CR,Hawkins N,Lopez OT,Bennett L,Welcher AA

更新日期：1997-05-01 00:00:00

abstract：:Both [3H]clonidine and [3H]idazoxan bind to alpha 2 adrenoceptors. The former also labels imidazoline receptors, and the latter non-adrenergic idazoxan binding sites. In order to investigate whether the imidazoline receptors and non-adrenergic idazoxan binding sites are identical, we compared the binding characteristi...

journal_title：Neuroscience

authors： De Vos H,Bricca G,De Keyser J,De Backer JP,Bousquet P,Vauquelin G

更新日期：1994-04-01 00:00:00

abstract：:Mature neurons contain two distinct regulated secretory pathways, characterized electron microscopically by so-called large dense core vesicles and small synaptic vesicles, respectively. Each vesicle type is characterized by vesicle-specific proteins, such as the granins (chromogranins/secretogranins) for the matrix o...

journal_title：Neuroscience

authors： Tixier-Vidal A,Barret A,Faivre-Bauman A,Huttner W,Wiedenmann B

更新日期：1992-01-01 00:00:00

abstract：:The p38 member of the mitogen-activated protein kinase superfamily is engaged by phosphorylation in response to environmental stress signals, and may have either permissive or inhibitor roles upon cell proliferation. The cell cycle in the proliferative zone of the retina is tightly controlled and proceeds in synchrony...

journal_title：Neuroscience

authors： Campos CB,Bédard PA,Linden R

更新日期：2002-01-01 00:00:00

abstract：:In unanesthetized cats it has been found that pyramidal volleys elicited upon medullary pyramidal tract stimulation were capable of modifying the discharge of 41% of intracerebellar nuclear cells, via pontocerebellar systems impinging predominantly on the lateral cerebellar cortex. The incidence of responsive cells wa...

journal_title：Neuroscience

authors： Giuffrida R,Licata F,Li Volsi G,Perciavalle V,Urbano A

更新日期：1983-06-01 00:00:00

abstract：:The central part of the retina, which includes the fovea, is substantially overrepresented in the topographic map of the retina in the striate cortex. We tested whether this simply reflects the uneven distribution of ganglion cells in the retina in accordance with the "principle" of peripheral scaling, or whether ther...

journal_title：Neuroscience

authors： Azzopardi P,Cowey A

更新日期：1996-06-01 00:00:00

abstract：:Early experience and social context interact to alter the phenotype of complex social behaviors. These early experiences can also result in alterations to cortical organization and connections. Given the ability of the neuropeptide oxytocin (OT) to modulate social and reproductive behavior, OT is likely involved in th...

journal_title：Neuroscience

authors： Duchemin A,Seelke AM,Simmons TC,Freeman SM,Bales KL

更新日期：2017-04-21 00:00:00

abstract：:Besides formation of neurofibrillary tangles and neuron loss, the Alzheimer's disease brain is characterized by neuritic plaques consisting of beta-amyloid peptide deposits and impaired neurotransmission. The proteins Munc18a, Munc18-interacting protein 1 and Munc18-interacting protein 2 mediate exocytosis and decreas...

journal_title：Neuroscience

authors： Jacobs EH,Williams RJ,Francis PT

更新日期：2006-01-01 00:00:00

abstract：:Polycytosine-binding proteins (PCBPs) are RNA-binding proteins that participate in post-transcriptional control pathways. Among the diverse functions of these proteins is the interaction with a 27 nucleotide pyrimidine-rich domain within the 3'UTR of tyrosine hydroxylase (TH) mRNA. Mutations to this domain result in d...

journal_title：Neuroscience

authors： Boschi NM,Takeuchi K,Sterling C,Tank AW

更新日期：2015-02-12 00:00:00

abstract：:Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and partner preference in adulthood. The medial preoptic area receives chemosensory inputs via a sexually dimorphic vome...

journal_title：Neuroscience

authors： Bakker J,Baum MJ,Slob AK

更新日期：1996-09-01 00:00:00

abstract：:The effects of muscle fatigue are known to be altered in older adults, and age-related changes in the brain are likely to be a contributing factor. However, the neural mechanisms underlying these changes are not known. The aim of the current study was to use transcranial magnetic stimulation combined with electroencep...

journal_title：Neuroscience

authors： Opie GM,Otieno LA,Pourmajidian M,Semmler JG,Sidhu SK

更新日期：2020-01-15 00:00:00

abstract：:The relation between quantal transmitter release and presynaptic Ca2+/Ba2+ entry at the mouse neuromuscular junction was studied, making use of the finding that in the presence of Ba2+ trains of nerve stimuli or brief nerve terminal depolarizations elicit "tails" of raised miniature end-plate potential frequency (fm) ...

journal_title：Neuroscience

authors： Quastel DM,Guan YY,Saint DA

更新日期：1992-12-01 00:00:00

abstract：:The experiments described herein present a method for tracking diffusion of the glucocorticoid receptor agonist RU28362 in brain following i.c.v. drug administration. A useful property of glucocorticoid receptor is that it is primarily cytoplasmic when unbound and rapidly translocates to the nucleus when bound by liga...

journal_title：Neuroscience

authors： Francis AB,Pace TW,Ginsberg AB,Rubin BA,Spencer RL

更新日期：2006-09-01 00:00:00

abstract：:Miniature endplate potentials were recorded from edge muscle fibers of frog sartorius muscles during high frequencies induced with K-propionate and during recovery. The identified neuromuscular junctions were studied with the electron microscope and their ultrastructure was correlated with amplitude and numbers of min...

journal_title：Neuroscience

authors： Florey E,Kriebel ME

更新日期：1988-12-01 00:00:00

abstract：:It is generally believed that haloperidol exerts its motor side effects and therapeutic effects mainly by antagonizing dopamine D(2) receptors in the striatum and the nucleus accumbens, respectively. Several neurotransmitters/modulators, including glutamate, acetylcholine, adenosine and histamine, affect dopaminergic ...

journal_title：Neuroscience

authors： Hussain N,Flumerfelt BA,Rajakumar N

更新日期：2002-01-01 00:00:00

abstract：:Using in vitro receptor autoradiographic techniques we have analysed the pre- and postnatal development of neurotensin receptors in the rat brain. Receptors were labeled with [3H] or [125I]neurotensin in mounted tissue sections from animals of ages gestational day 14 until the postnatal day 21 as well as young adult a...

journal_title：Neuroscience

authors： Palacios JM,Pazos A,Dietl MM,Schlumpf M,Lichtensteiger W

更新日期：1988-04-01 00:00:00

abstract：:During spinal cord maturation neuronal excitability gradually differentiates to meet different functional demands. Spontaneous activity, appearing early during spinal development, is regulated by the expression pattern of ion channels in individual neurons. While emerging excitability of embryonic motoneurons has been...

journal_title：Neuroscience

authors： Furlan F,Guasti L,Avossa D,Becchetti A,Cilia E,Ballerini L,Arcangeli A

更新日期：2005-01-01 00:00:00

abstract：:Immunosuppression remains a key issue in neural transplantation. Systemic administration of cyclosporin-A is currently widely used but has many severe adverse side effects. Newer immunosuppressive agents, such as tacrolimus (TAC) and rapamycin (RAPA), have been investigated for their neuroprotective properties on dopa...

journal_title：Neuroscience

authors： Alemdar AY,Sadi D,McAlister V,Mendez I

更新日期：2007-04-25 00:00:00

abstract：:Light-microscope visualization in rat brain of a pattern of distribution of immunoreactivity, which included immunolabeled perikarya and beaded processes, was achieved using an immunoaffinity purified polyclonal antibody, Ab165, which recognizes the amino acid sequence, IRNLRQDRSKYY, found in the mu-opioid binding pro...

journal_title：Neuroscience

authors： Hiller JM,Zhang Y,Bing G,Gioannini TL,Stone EA,Simon EJ

更新日期：1994-10-01 00:00:00

abstract：:It is now well established that vestibular information plays an important role in spatial memory processes. Although vestibular lesions induce anxiety in humans, this finding remains controversial in rodents. However, it is possible that anxiety-related behavior is associated with spatial memory impairments after vest...

journal_title：Neuroscience

authors： Machado ML,Lelong-Boulouard V,Smith PF,Freret T,Philoxene B,Denise P,Besnard S

更新日期：2012-08-30 00:00:00

abstract：:Clinical and animal studies indicate that maternal consumption of ethanol during pregnancy increases alcohol drinking in the offspring. Possible underlying mechanisms may involve orexigenic peptides, which are stimulated by prenatal ethanol exposure and themselves promote drinking. Building on evidence that ethanol st...

journal_title：Neuroscience

authors： Chang GQ,Karatayev O,Leibowitz SF

更新日期：2015-12-03 00:00:00

abstract：:Intersegmental interneurons with relatively short axons perform an important role in the coordination of limb movement but surprisingly little is known about their organization and how they contribute to neuronal networks in the adult rat. We undertook a series of anatomical tract-tracing studies to label cell bodies ...

journal_title：Neuroscience

authors： Liu TT,Bannatyne BA,Maxwell DJ

更新日期：2010-12-01 00:00:00

abstract：:To study the effect of inositol 1,4,5-trisphosphate (IP(3)) in isolated frog vomeronasal microvillar receptor neurones, whole-cell recordings were performed with 0.5 microM caged IP(3) dissolved in the pipette solution. IP(3) was released by photolysis of caged IP(3) initiated by a 0.8-ms ultraviolet flash from a xeno...

journal_title：Neuroscience

authors： Gjerstad J,Valen EC,Trotier D,Døving K

更新日期：2003-01-01 00:00:00

abstract：:In vivo cyclic adenosine monophosphate (cAMP)-induced N-methyl-D-aspartate receptor and mitogen-activated protein kinase activation was investigated in the dorsal striatum by semiquantitative immunocytochemistry. Intracerebroventricular infusion of 8-bromo-adenosine 3',5'-cyclic monophosphorothioate, Sp isomer (Sp-8-B...

journal_title：Neuroscience

authors： Choe ES,McGinty JF

更新日期：2000-01-01 00:00:00