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In vitro tumoral progression of human bladder carcinoma: role for TGFbeta.

Abstract：

OBJECTIVE:Investigating whether extracellular factors are possible actors in tumoral progression in bladder carcinoma. METHODS:RT112/G2 bladder tumour cells were grown in presence of TGFbeta and analysed by immunological and cDNA microarray techniques. RESULTS:TGFbeta inhibited cell proliferation, reduced TNFalpha- and IFNgamma-induced apoptosis by decreasing TNFalpha-RI and IFNgamma-R antigen expression. It also inhibited cleaved caspase 8 and 9 expression, decreased E-cadherin, and increased BclxL and cyclooxygenase-2 expression. The cDNA microarray approach showed that TGFbeta up-regulated the expression of genes with defined roles in tumoral progression sometimes associated with poor outcome in bladder cancer. CONCLUSION:These results suggest that a part of the bladder tumoral progression process may be related to the action of exogenous TGFbeta confirming the possible role for the microenvironment.

journal_name

Eur Urol

journal_title

European urology

authors

Champelovier P,El Atifi M,Mantel F,Rostaing B,Simon A,Berger F,Seigneurin D

doi

10.1016/j.eururo.2005.06.005

keywords:

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

846-51

issue

5

eissn

0302-2838

issn

1873-7560

pii

S0302-2838(05)00369-6

journal_volume

48

pub_type

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