[Direct inhibition of thrombin. A new strategy for the treatment of atrial fibrillation and acute coronary syndrome?].

abstract：:Increased vasoconstriction, activation of platelet vessel wall interaction and invasion of monocytes into the subintima as well as vascular smooth muscle cell proliferation play a fundamental role in the pathogenesis of coronary artery disease. Acute coronary syndromes such as myocardial infarction and unstable angina...

journal_title：Herz

authors： Fichtlscherer S,Zeiher AM

更新日期：1999-11-01 00:00:00

abstract：:The therapy of patients with syncope is oriented to the underlying pathophysiological mechanisms. Patients with reflex syncope require careful education regarding recognition of warning signs and the avoidance of trigger factors. Treatment with beta blockers is nowadays obsolete. Even other drugs have failed to show a...

journal_title：Herz

authors： Andresen D

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Cardiac involvement may precede the onset of muscular manifestations in Becker muscular dystrophy (BMD), but Wolff-Parkinson-White (WPW) syndrome has not been reported as initial cardiac manifestation of BMD. CASE STUDY:In a 43-year-old, HIV-negative male, WPW syndrome was diagnosed at age 26 years upon a r...

journal_title：Herz

authors： Finsterer J,Stöllberger C,Quasthoff S

更新日期：2008-06-01 00:00:00

abstract：:In order to understand the mechanics of left ventricular (LV) diastolic filling it has become important to understand the role of the pericardium. This is because it has been demonstrated that the LV pressure-volume relationship can be shifted by previously unrecognized changes in pericardial "pressure" and, therefore...

journal_title：Herz

authors： Tyberg JV,Smith ER

更新日期：1990-12-01 00:00:00

abstract：:Coronary artery disease is still the no. 1 killer in the developed countries and must thus be detected and treated at an earlier stage. If coronary artery disease is advanced, patients have to be examined regarding the need for revascularization. For secondary prevention, of course, an optimal change of life style and...

journal_title：Herz

authors： Silber S,Krischke I,Prohaska M

更新日期：2000-09-01 00:00:00

abstract：:Formerly the term alcoholism has been defined only by alcohol-related conditions. About 20 years ago a WHO committee recommended to differentiate between alcohol abuse and alcohol dependence. The new classifications and manuals followed this proposal: Criteria for alcohol abuse are still alcohol sequelae whereas alcoh...

journal_title：Herz

authors： Feuerlein W

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:Little is known about cardiac involvement in m.3243A>G variant carriers. Thus, this study aimed to assess type and frequency of cardiac disease in symptomatic and asymptomatic m.3243A>G carriers. METHODS:Systematic literature review. RESULTS:The m.3243A>G variant may manifest phenotypically as mitochondria...

journal_title：Herz

authors： Finsterer J,Zarrouk-Mahjoub S

更新日期：2020-06-01 00:00:00

abstract：:Diabetes is associated with the development of premature cardiovascular disease (CVD), which relates to the clustering of risk factors such as dyslipidaemia, hypertension, obesity and hyperglycaemia in the presence of insulin resistance. In addition, diabetes is associated with an inflammatory and pro-thrombotic envir...

journal_title：Herz

authors： King RJ,Grant PJ

更新日期：2016-05-01 00:00:00

abstract：:Heart failure is one of the leading diseases in internal medicine worldwide. Because of the increase in population aging, the incidence and prevalence of heart insufficiency is rising annually and is now the most frequent individual diagnosis among hospitalized patients in Germany. The mortality rate has recently been...

journal_title：Herz

authors： Wintrich J,Kindermann I,Böhm M

更新日期：2020-04-01 00:00:00

abstract：:From April 1973 through March 1978, 34 patients with univentricular heart and outlet chamber underwent repair by septation of the ventricle. Three had normally related great arteries in which the pulmonary artery arose from the outlet chamber. Six patients had an anterior aorta arising from an anterior or right-sided ...

journal_title：Herz

authors： Danielson GK,McGoon DC,Maloney JD,Ritter DG

更新日期：1979-04-01 00:00:00

abstract：:Myocardial infarction (MI) as an acute and life-threatening complication of coronary heart disease is one of the most frequent causes of death in Germany. Therefore, diagnosis, risk stratification and treatment of acute MI are of great clinical relevance. Specific recommendations concerning diagnosis of acute MI can b...

journal_title：Herz

authors： Weber M,Hamm C

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Experimental and clinical studies have suggested that the presence of fragmented QRS complex (fQRS) is associated with various cardiovascular diseases. fQRS may predict major adverse cardiovascular events (MACE). The current meta-analysis was performed using clinical outcome studies to evaluate the role of f...

journal_title：Herz

authors： Xu Y,Qiu Z,Xu Y,Bao H,Gao S,Cheng X

更新日期：2015-03-01 00:00:00

abstract：CASE REPORT:A 41-year-old male saw his general practitioner because of progressive atypical angina symptoms and palpitations for the last 7 years. Chest X-ray showed a mediastinal mass. Further investigation by computed tomography (CT), magnetic resonance imaging (MRI) and cardiac catheterization revealed two bronchoge...

journal_title：Herz

authors： Kusch B,Vogt S,Rybinski L,Moosdorf R

更新日期：2002-12-01 00:00:00

abstract：:In congestive heart failure (CHF), even today, pharmacotherapy renders primarily only symptomatic improvement. The success of the treatment is basically dependent on the degree of functional myocardial impairment, that is, the condition of the inadequately treatable underlying disease. Treatment should be differential...

journal_title：Herz

authors： Thormann J,Kramer W,Dieterich HA

更新日期：1990-06-01 00:00:00

abstract：:Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a primary myocardial disorder that is characterized by localized or diffuse atrophy of predominantly right ventricular myocardium with subsequent replacement by fatty and fibrous tissue. Arrhythmias of right ventricular origin are the main clinical manifestatio...

journal_title：Herz

authors： Haverkamp W,Rolf S,Osterziel KJ,Dietz R,Peters S

更新日期：2005-09-01 00:00:00

abstract：:The rapid increase of morbid obesity has become an important task in the Western world in recent years. Since conservative treatments have failed to prove sufficient efficacy, surgery has turned out to be the most powerful option in treating morbid obesity. In this paper, the different surgical techniques with their a...

journal_title：Herz

authors： Wildi S,Müller MK,Clavien PA,Weber M

更新日期：2006-05-01 00:00:00

abstract：:Obstructive pulmonary vascular disease and pulmonary hypertension are facts daily encountered by pediatric cardiologists. However longterm thromboembolism, pulmonary vascular obstruction and cor pulmonale are rare conditions in children. The case report of a four years old child treated by a Pudenz ventriculo venous s...

journal_title：Herz

authors： Keck EW,Feige M,Riesner K

更新日期：1978-04-01 00:00:00

abstract：:Sudden cardiac death and chronic heart failure are among the main contributors to persisting high mortality rates in Germany. In addition to removal of causal factors and guideline-conform pharmacological therapy, therapy with cardiac implantable electronic devices (CIED) is of undisputed importance. Subcutaneous defi...

journal_title：Herz

authors： Kuschyk J,Rudic B,Borggrefe M,Akin I

更新日期：2017-04-01 00:00:00

abstract：:Venous disease of the lower extremities comprises several common conditions such as varicose veins, superficial thrombophlebitis, deep venous thrombosis and chronic venous insufficiency. The high prevalence and increasing incidence with age of these disorders impose relevant diagnostic and therapeutic concerns. Varico...

journal_title：Herz

authors： Do DD,Husmann M

更新日期：2007-02-01 00:00:00

abstract：:I. The actual data base on the decision-making process of indication for revascularization reveals that angiographic severity of coronary artery disease (CAD) is the primary determinant of referral to coronary interventional procedures. Several recent studies demonstrated that after an acute myocardial infarction, wom...

journal_title：Herz

authors： Tillmanns H,Waas W,Voss R,Grempels E,Hölschermann H,Haberbosch W,Waldecker B

更新日期：2005-08-01 00:00:00

abstract：:Independent of the underlying cause, pulmonary hypertension (PH) remains a devastating condition that is characterized by limited survival. Cumulating evidence indicates that in addition to a dysbalance of mediators regulating vascular tone and growth factors promoting vascular remodeling, failure to resolve inflammat...

journal_title：Herz

authors： Berghausen EM,Feik L,Zierden M,Vantler M,Rosenkranz S

更新日期：2019-04-01 00:00:00

abstract：:At present, in patients with diabetes mellitus and coronary multivessel disease no fixed general recommendation can be given in favor or to the disadvantage of surgical revascularization or in favor or to the disadvantage of percutaneous coronary intervention (PCI). In cases with an evidence-based indication for coron...

journal_title：Herz

authors： Dörr R

更新日期：2010-05-01 00:00:00

abstract：:After an unusually long period of time of 6 years, in August 2019 the updated version of the European Society of Cardiology (ESC) guidelines from 2013 on the management of stable coronary artery disease was published. The course of "stable" coronary artery disease is only assumed to be stable and pathologically is oft...

journal_title：Herz

authors： Silber S

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Galectin-3 has been reported as a mediator of heart failure (HF) development and progression. Most studies, however, have been conducted on patients with chronic HF rather than acute HF (AHF). The aim of this study was to confirm galectin-3 as a prognostic marker in subjects with AHF and to investigate its p...

journal_title：Herz

authors： Lala RI,Lungeanu D,Darabantiu D,Pilat L,Puschita M

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:: Drug-eluting stents (DES) have been shown to reduce the risk of in-stent stenosis, one of the major problems of percutaneous coronary intervention (PCI) with implantation of baremetal stents. DES are approved in Germany since 2002. The following study is based on data of the ALKK PCI registry a...

journal_title：Herz

authors： Klein B,Zahn R,Heer T,Hochadel M,Tebbe U,Darius H,Kerber S,Schumacher B,Grube E,Hauptmann KE,Glunz HG,Senges J,Zeymer U

更新日期：2008-09-01 00:00:00

abstract：:Access to the intrinsic cardiac autonomic nervous system can now be achieved via percutaneous catheter stimulation techniques. Thereby, cardiac functions like atrioventricular nodal conduction, sinus cycle length and ventricular inotropy can be dynamically regulated. The present article provides examples of this new t...

journal_title：Herz

authors： Schauerte P,Schimpf T,Mischke K,Zarse M,Schmid M,Plisiene J,Maurath P,Kelm M,Pauza DH

更新日期：2006-04-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most frequently encountered sustained arrhythmia with a prevalence of 0.5-10%, depending predominantly on age. The arrhythmia is associated with significant morbidity and mortality, mainly due to thromboembolic events including stroke and systemic embolisms. These complications can be e...

journal_title：Herz

authors： Erath JW,Hohnloser SH

更新日期：2018-02-01 00:00:00

abstract：:Coronary artery disease (CAD) is a leading cause of morbidity and mortality in western countries and is of significant socio-economic importance due to its increasing prevalence. Until percutaneous coronary interventions (PCI) were established, CAD could only be treated by surgical revascularization or pharmacological...

journal_title：Herz

authors： Möllmann H,Szardien S,Kempfert J,Nef H,Liebetrau C,Walther T,Hamm C

更新日期：2013-08-01 00:00:00

abstract：:Familial dilated cardiomyopathy (F-DCM) describes a clinically and genetically heterogeneous group of diseases, mostly inherited as autosomal dominant traits, having idiopathic left ventricular dilatation and dysfunction as a common phenotype. The age of onset, rate of progression, disease complications, as well as ov...

journal_title：Herz

authors： Serio A,Narula N,Kodama T,Favalli V,Arbustini E

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Once contraindicated, beta-blockers have become an established, evidence-based, recommended treatment concept in chronic heart failure during the last years. PATHOPHYSIOLOGY:The increased activation of the adrenergic system in heart failure syndrome, which leads to transmission of several adverse biological...

journal_title：Herz

authors： Hoffman J,Grimm W,Maisch B

更新日期：2002-03-01 00:00:00