RNA polymerase-associated transcription specificity factor encoded by vaccinia virus.

abstract：:The effect of 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent tumor promoter, on the synthesis of proteins in BALB/c 3T3 mouse fibroblasts has been studied. When [35S]methionine-labeled proteins synthesized after the addition of TPA were analyzed by one- or two-dimensional polyacrylamide gel electrophoresis, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hiwasa T,Fujimura S,Sakiyama S

更新日期：1982-03-01 00:00:00

abstract：:What are the forces that shape the structure of prokaryotic genomes: the order of genes, their proximity, and their orientation? Coregulation and coordinated horizontal gene transfer are believed to promote the proximity of functionally related genes and the formation of operons. However, forces that influence the str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kolesov G,Wunderlich Z,Laikova ON,Gelfand MS,Mirny LA

更新日期：2007-08-28 00:00:00

abstract：:We prove theorems on the structure of the fundamental group of a compact riemannian manifold of non-positive curvature. In particular, a conjecture of J. Wolf [J. Differential Geometry, 2, 421-446 (1968)] is proved. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yau ST

更新日期：1970-10-01 00:00:00

abstract：:Experimental systemic lupus erythematosus (SLE) can be induced in naive mice by immunization with a murine monoclonal anti-DNA antibody (mAb), 5G12, that bears a major idiotype designated 16/6 Id. Strain-dependent differences were observed in the proliferative responses of lymph node cells of mice immunized with two p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waisman A,Ruiz PJ,Israeli E,Eilat E,Könen-Waisman S,Zinger H,Dayan M,Mozes E

更新日期：1997-04-29 00:00:00

abstract：:The development of Drosophila requires the function of the CREB-binding protein, dCBP. In flies, dCBP serves as a coactivator for the transcription factors Cubitus interruptus, Dorsal, and Mad, and as a cosuppressor of Drosophila T cell factor. Current models propose that CBP, through its intrinsic and associated hist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bantignies F,Goodman RH,Smolik SM

更新日期：2002-03-05 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) specifies in the infected cell a set of polypeptides (alpha) whose mRNAs are made in the absence of protein synthesis. The individual mRNAs specifying alpha polypeptides 0, 4, 22, and 27 were purified by hybridization to strand-separated or total HSV-1 DNA fragments cloned in pBR322 plas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackem S,Roizman B

更新日期：1980-12-01 00:00:00

abstract：:Cellular morphogenesis relies partly on cell polarization by the cytoskeleton. In the fission yeast Schizosaccharomyces pombe, it is well established that microtubules (MTs) deliver the spatial cue Tea1, a kelch repeat protein, to the tip regions to direct the growth machinery at the cell tips driving the linear exten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheffler K,Recouvreux P,Paoletti A,Tran PT

更新日期：2014-12-16 00:00:00

abstract：:Although it has been known for decades that the tight junctions of fluid-transporting epithelia are leaky to ions, it has not been possible to determine directly whether significant transjunctional water movement also occurs. An optical microscopic technique was developed for the direct visualization of the flow veloc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovbasnjuk O,Leader JP,Weinstein AM,Spring KR

更新日期：1998-05-26 00:00:00

abstract：:The identities between homogeneous expressions in rank 1 vectors and rank n - 1 covectors in a Grassmann-Cayley algebra of rank n, in which one set occurs multilinearly, are shown to represent a set of dimension-independent identities. The theorem yields an infinite set of nontrivial geometric identities from a given ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hawrylycz M

更新日期：1995-03-14 00:00:00

abstract：:Activation of p53 tumor suppressor by antagonizing its negative regulator murine double minute (MDM)2 has been considered an attractive strategy for cancer therapy and several classes of p53-MDM2 binding inhibitors have been developed. However, these compounds do not inhibit the p53-MDMX interaction, and their effecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves B,Thompson T,Xia M,Janson C,Lukacs C,Deo D,Di Lello P,Fry D,Garvie C,Huang KS,Gao L,Tovar C,Lovey A,Wanner J,Vassilev LT

更新日期：2012-07-17 00:00:00

abstract：:Wnt/β-catenin signaling controls development and adult tissue homeostasis by regulating cell proliferation and cell fate decisions. Wnt binding to its receptors Frizzled (FZD) and low-density lipoprotein-related 6 (LRP6) at the cell surface initiates a signaling cascade that leads to the transcription of Wnt target ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerlach JP,Jordens I,Tauriello DVF,van 't Land-Kuper I,Bugter JM,Noordstra I,van der Kooij J,Low TY,Pimentel-Muiños FX,Xanthakis D,Fenderico N,Rabouille C,Heck AJR,Egan DA,Maurice MM

更新日期：2018-04-24 00:00:00

abstract：:We study the electrophoretic transport of single-stranded RNA molecules through 1.5-nm-wide pores of carbon nanotube membranes by molecular dynamics simulations. From approximately 170 individual RNA translocation events analyzed at full atomic resolution of solvent, membrane, and RNA, we identify key factors in membr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh IC,Hummer G

更新日期：2004-08-17 00:00:00

abstract：:Phytochrome A (phyA) is the only plant photoreceptor that perceives far-red light and then mediates various responses to this signal. Phosphorylation and dephosphorylation of oat phyA have been extensively studied, and it was shown that phosphorylation of a serine residue in the hinge region of oat phyA could regulate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Y,Yang L,Duan J,Cheng J,Shen Y,Wang X,Han R,Li H,Li Z,Wang L,Terzaghi W,Zhu D,Chen H,Deng XW,Li J

更新日期：2018-12-11 00:00:00

abstract：:Production of reactive oxygen intermediates (ROI) and a form of programmed cell death called hypersensitive response (HR) are often associated with disease resistance of plants. We have previously shown that the Rac homolog of rice, OsRac1, is a regulator of ROI production and cell death in rice. Here we show that the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ono E,Wong HL,Kawasaki T,Hasegawa M,Kodama O,Shimamoto K

更新日期：2001-01-16 00:00:00

abstract：:Population intelligence quotients increased throughout the 20th century-a phenomenon known as the Flynn effect-although recent years have seen a slowdown or reversal of this trend in several countries. To distinguish between the large set of proposed explanations, we categorize hypothesized causal factors by whether t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bratsberg B,Rogeberg O

更新日期：2018-06-26 00:00:00

abstract：:One signature of adaptive radiation is a high level of trait change early during the diversification process and a plateau toward the end of the radiation. Although the study of the tempo of evolution has historically been the domain of paleontologists, recently developed phylogenetic tools allow for the rigorous exam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agrawal AA,Fishbein M,Halitschke R,Hastings AP,Rabosky DL,Rasmann S

更新日期：2009-10-27 00:00:00

abstract：:To investigate how T cells recognize allogeneic class I proteins encoded by the major histocompatibility complex (MHC), we examined the human cytotoxic T lymphocytes (CTL) elicited in a mixed lymphocyte reaction against a lymphoblastoid B-cell line (JY) whose MHC-class I proteins are HLA-A2 and -B7. By panning the res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elliott TJ,Eisen HN

更新日期：1988-04-01 00:00:00

abstract：:Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA, here termed CSF-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Springer S,Zhang M,McMahon KW,Kinde I,Dobbyn L,Ptak J,Brem H,Chaichana K,Gallia GL,Gokaslan ZL,Groves ML,Jallo GI,Lim M,Olivi A,Quinones-Hinojosa A,Rigamonti D,Riggins GJ,Sciubba DM,Weingart JD,Wolinsky JP

更新日期：2015-08-04 00:00:00

abstract：:RNA movements and localization pervade biology, from embryonic development to disease. To identify RNAs at specific locations, we developed a strategy in which a uridine-adding enzyme is anchored to subcellular sites, where it directly marks RNAs with 3' terminal uridines. This localized RNA recording approach yields ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Medina-Munoz HC,Lapointe CP,Porter DF,Wickens M

更新日期：2020-09-22 00:00:00

abstract：:Prochlorococcus is an abundant marine cyanobacterium that grows rapidly in the environment and contributes significantly to global primary production. This cyanobacterium coexists with many cyanophages in the oceans, likely aided by resistance to numerous co-occurring phages. Spontaneous resistance occurs frequently i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Avrani S,Lindell D

更新日期：2015-04-28 00:00:00

abstract：:We present a unique proxy for the reconstruction of variation in precipitation over the Amazon: oxygen isotope ratios in annual rings in tropical cedar (Cedrela odorata). A century-long record from northern Bolivia shows that tree rings preserve the signal of oxygen isotopes in precipitation during the wet season, wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brienen RJ,Helle G,Pons TL,Guyot JL,Gloor M

更新日期：2012-10-16 00:00:00

abstract：:Through rapid genetic adaptation and natural selection, the Plasmodium falciparum parasite--the deadliest of those that cause malaria--is able to develop resistance to antimalarial drugs, thwarting present efforts to control it. Genome-wide association studies (GWAS) provide a critical hypothesis-generating tool for u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park DJ,Lukens AK,Neafsey DE,Schaffner SF,Chang HH,Valim C,Ribacke U,Van Tyne D,Galinsky K,Galligan M,Becker JS,Ndiaye D,Mboup S,Wiegand RC,Hartl DL,Sabeti PC,Wirth DF,Volkman SK

更新日期：2012-08-07 00:00:00

abstract：:With every pair of bounded self-adjoint operators {U,V} on Hilbert space such that VU - UV = (1/pii)C, where C is trace class, there is associated a certain function of two complex variables called the determining function of the pair. It was previously shown how the determining function can be obtained as the solutio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pincus JD

更新日期：1971-08-01 00:00:00

abstract：:Somatic crossing over in flies heterozygous for a dominant Minute mutant may result in two cells, homozygous for wild type and Minute, respectively. If both cells took part in development, a twin spot of two genotypes, different from the rest of the body, would result. Two-hundred wild type spots were found, none of w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stern C,Tokunaga C

更新日期：1971-02-01 00:00:00

abstract：:Recently, we described a recurrent variant translocation, t(11;17)(q23;q21), in acute promyelocytic leukemia (APL) which juxtaposes PLZF, a gene encoding a zinc finger protein, to RARA, encoding retinoic acid receptor alpha (RAR alpha). We have now cloned cDNAs encoding PLZF-RAR alpha chimeric proteins and studied the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Guidez F,Rousselot P,Agadir A,Chen SJ,Wang ZY,Degos L,Zelent A,Waxman S,Chomienne C

更新日期：1994-02-01 00:00:00

abstract：:A cylindrical detonating explosive behaves like a non-Newtonian viscous fluid emerging from a cylindrical pipe. The expression for non-Newtonian viscous flow has been applied to detonating explosives. The resultant fit to emerging flame fronts from detonation is excellent for a wide variety of detonating explosives bo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coon N,Ma SM,Redington PK,Brown B,Eyring H

更新日期：1980-10-01 00:00:00

abstract：:The ability of the isolated perfused rat liver to differentiate between chylomicrons and remnants with either high or low apoprotein E:C ratios was investigated. Remnants were prepared in hepatectomized rats injected with chylomicrons double-labeled with [3H]cholesterol and 14C-labeled fatty acids. By densitometric sc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borensztajn J,Kotlar TJ

更新日期：1984-09-01 00:00:00

abstract：:One of the most basic predictions of almost any model of crime is that individual time preferences matter. However, empirical evidence on this fundamental property is essentially nonexistent. To our knowledge, this paper provides the first pieces of evidence on the link between time discounting and crime. We use a uni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Åkerlund D,Golsteyn BH,Grönqvist H,Lindahl L

更新日期：2016-05-31 00:00:00

abstract：:Conformationally compromised oncogenic mutants of the tumor suppressor protein p53 can, in principle, be rescued by small molecules that bind the native, but not the denatured state. We describe a strategy for the rational search for such molecules. A nine-residue peptide, CDB3, which was derived from a p53 binding pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Friedler A,Hansson LO,Veprintsev DB,Freund SM,Rippin TM,Nikolova PV,Proctor MR,Rüdiger S,Fersht AR

更新日期：2002-01-22 00:00:00

abstract：:Adrenal chromaffin granules contain at least 10 peptides, ranging in size from 3 to 5 kilodaltons, that yield, upon digestion with trypsin, peptides that show specific binding to opiate receptors. All are distinctly different from beta-endorphin. Two of these peptides have been purified to homogeneity and subjected to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimura S,Lewis RV,Stern AS,Rossier J,Stein S,Udenfriend S

更新日期：1980-03-01 00:00:00