Abstract：
:Despite the compelling evidence for a strong heritability of schizophrenia, the aetiology and genetic underpinnings of this disabling disease still remain unclear. Reasonable explanations for current problems in identifying candidate genes for schizophrenia are the complexity of its genetic background as well as the heterogeneity of the clinical appearance of this disease. For a higher efficiency in genetic investigations, a new approach came up which defines clinically distinct traits much more precisely: the so called endophenotype concept. Schizophrenic patients suffer from marked cognitive deficits. These deficits are closely related to the neurobiological basis of the disease, exhibit a high negative impact on clinical outcome, and may serve as endophenotypes for genetic studies. Identification of neurocognitive endopenotypes is usually performed in terms of a combination of neuropsychological tests and neurophysiological measurements. Thus, future genetic investigations as well as psychosocial and psychopharmacological therapy strategies will focus on the severity and potential therapeutic modification of cognitive deficits in order to improve psychosocial reintegration of schizophrenic patients in the long-term.
journal_name
Psychiatr Praxjournal_title
Psychiatrische Praxisauthors
Opgen-Rhein C,Neuhaus A,Urbanek C,Dettling Mdoi
10.1055/s-2004-828480keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
S194-9eissn
0303-4259issn
1439-0876journal_volume
31 Suppl 2pub_type
杂志文章abstract：:About one third (29.5%) of the population living within the area of Frankfurt, for which the psychiatric university clinic provides psychiatric service, are foreigners. For the better understanding of our foreign psychiatric inpatients treated in our clinic in in 1992, the diagnostic spectrum and the nationalities of ...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:Polish psychiatry was since its origin deeply influenced by German (Austrian) and Russian psychiatry. After the German assault Polish psychiatric patients were the first victims of mass executions, and the first to be killed by new developed "gassing" technology. Especially cruel was the fate of Jewish patients. Germa...
journal_title：Psychiatrische Praxis
pub_type： 历史文章,杂志文章
doi：10.1055/s-0034-1370066
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:Little is known about the effectiveness and the cost of care for patients treated in vocational rehabilitation programs,although vocational therapy is an essential part of inpatient treatment and community care of patients with schizophrenia. METHODS:As a part of a randomised controlled trial in 5 centres, t...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1055/s-2006-951949
更新日期：2007-07-01 00:00:00
abstract：:Pregabalin is a substance which modulates monoamine release in "hyper-excited" neurons. It binds potently to the α2-δ subunit of calcium channels. Pilotstudies on alcohol- and benzodiazepine dependent patients reported a reduction of withdrawal symptoms through Pregabalin. To our knowledge, no studies have been conduc...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：10.1055/s-0032-1305042
更新日期：2012-10-01 00:00:00
abstract：:The conditions determining statutory offences as represented by indictable sex offences, have been amended and revised by the 4th Penal Reform Law of the Federal German Penal Code, in 1973, under the heading "Indictable Offences against Sexual Self-Determination". This heading, which is meant to convey a programme, ho...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1983-05-01 00:00:00
abstract：AIM:Evaluations of clozapine treatment by relatives of schizophrenic patients were assessed as part of an exploratory study and compared with the patients' own assessment. METHOD:46 relatives of individuals suffering from schizophrenia were questioned by means of a problem-centred interview. RESULTS:In addition to th...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：OBJECTIVE:Although English is medicine's lingua franca, practising physicians in Germany express the need for articles in German. This study aimed at surveying the number and characteristics of German-language psychiatric journals in Germany. METHODS:Journals were identified by the standard handbook "Fachmedien Gesund...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：10.1055/s-0031-1276955
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Is it necessary to understand your vis a vis or is it enough to meet, to get in touch? Awareness of the different perception of reality is important. INTERINDIVIDUELL: Defined as basic requirements for getting in touch, mutual modelling and interchange were "Knowing your own world", "Being curious about th...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：10.1055/s-2003-38550
更新日期：2003-04-01 00:00:00
abstract：:A rehabilitation programme at the University Clinic of Social Psychiatry, Berne, is described. The facility includes a half-way house and sheltered home in a suburb, where 20 psychiatric long-stay patients are trained for an independent life in the community. In a follow-up study 80 patients, mostly chronic schizophre...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：OBJECTIVES:This project evaluates whether a multidisciplinary consultation-liaison team with special geropsychiatric experience can help to reduce complex care problems in mentally ill nursing-home residents. METHODS:Prospective longitudinal study of patients living in 5 nursing homes in Germany, supplemented by exper...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：10.1055/s-0031-1276836
更新日期：2012-01-01 00:00:00
abstract：:In a total sample of 141 mentally retarded adults the quality of social relationships was assessed by the newly developed "Interview for Social Support in Mentally Retarded Adults". Severely mentally retarded persons have close and intimate relationships to a consistently lesser extent than mildly retarded persons. Th...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:Since the end of the 1990s the Westfälische Klinik Lengerich has offered an inpatient psychiatric treatment of an psychiatric ill parent--combined with a pedagogic attendance of the child taken along. The following article describes our experience in that matter, from a ward concentrated on psychotherapy. In selected ...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：10.1055/s-2001-12672
更新日期：2001-04-01 00:00:00
abstract：:Two perspectives of mental health care in Leipzig are outlined. Critical aspects of deinstitutionalization are discussed from the point of view of an office-based Nervenarzt (neurologist and psychiatrist). The limitations of office-based practice in providing care for the severely mentally ill (SMI) are described, i.e...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章,评审
doi：
更新日期：2000-09-01 00:00:00
abstract：:Based on the evaluation of case reports of 15 inpatients treated between 1971 and 1986 who had been suffering from persistent alcoholic jealousy mania for at least three years, the psychopathological characteristics of this disease are outlined to define two types of courses of the disturbance: on the one hand, the mo...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：OBJECTIVE:While lots of projects focus on "stigmatization by others" in people with mental diseases, the problem of "self-stigmatization" is rarely considered in their treatment.Thus, the program "Stigma Management" aims on the conception of a therapeutic manual concerning self-stigmatization. As experts on their own, ...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：10.1055/s-0034-1387456
更新日期：2016-01-01 00:00:00
abstract：:Changes in the provision of psychiatric services within the last decennials are probably best understood if the impact of national socialism on clinical psychiatry is regarded. Many psychiatrists took part in the "Aktion T4" the organised killing of their patients, at least they did not resist campaigns directed to ki...
journal_title：Psychiatrische Praxis
pub_type： 历史文章,杂志文章
doi：10.1055/s-2004-828483
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:gamma-Hydroxybutyrat (GHB) is used medically for narcolepsy and as a narcotic. It is also a rare illegal drug. In this case report the development of a GHB-dependency against the background of a primary alcohol dependency is described. METHODS:Based on established alcohol withdrawal scales (AWSS by Wetterlin...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：10.1055/s-0028-1090089
更新日期：2009-10-01 00:00:00
abstract：:It is unfortunate that mental patients with long-term hospitalisation patterns are still necessarily scheduled for long-term stay in mental hospitals and institutions designed for the care and treatment of psychiatric cases, since such institutions are characterized by a rather sterile, low-stimulation atmosphere unde...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1987-05-01 00:00:00
abstract：:The increasing employment of graduates in psychology (Diplom-Psychologen) in psychiatric hospitals not only expands therapeutical facilities as a result of cooperation between psychologists and physicians; it also entails structural re-organisation both formally and in terms of contents, of behavioural rituals which h...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：OBJECTIVE:To provide information about occurrence and patterns of geriatric morbidity and need for long-term care in patients newly diagnosed with dementia compared to controls without dementia. METHODS:An analysis of administrative data was conducted to compare the geriatric outpatient diagnoses and the patterns of c...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：10.1055/s-0032-1305010
更新日期：2012-07-01 00:00:00
abstract：:The interrelationship and predictive validity of certain outcome predictors were studied on 54 young schizophrenic patients. In the first year after outburst the illness shows a great variability and the course seems to be open. Neither the premorbid social adjustment nor the amount of negative symptoms seem to predic...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:All the different branches in forensic psychiatry have to face identical handicaps resulting from the difficulties in cooperation with the law-court. For the psychiatrist, his identity as a therapist is contradictory to his forensic tasks. The paper deals with the resulting dilemmata (partiality v. neutrality; diagnos...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章,评审
doi：
更新日期：1988-03-01 00:00:00
abstract：OBJECTIVE:This study investigates the effects of probationary work for psychiatric patients in community-based small businesses during their inpatient or day care. METHODS:Patients were evaluated for working capacity, psychopathology, motivation for work and patient satisfaction (n = 69). RESULTS:The results confirm ...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：:The authors report their three years experience with treating addicts (both alcoholics and users of prescription and illegal drugs) in a specialized unit employing a low-threshold admission policy. Difficulties as well as advantages of the concept are discussed. For the common treatment of patients addicted to differe...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:The report describes the inpatient and out-patient treatment facilities for alcoholics in a defined catchment area and the experience gathered by the initiation of out-patient group therapy for a group of alcoholics at the general community hospital in Offenbach/Main. The goal of the group therapy at the hospital was ...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Within the process of individual psychotherapy the author stresses the importance of understanding the initial everyday life view of "what is about being sick" for to establish a working, and cooperative setting. Thus, a three step procedure has been developed to guide the patient to a self responsible attitude toward...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:In the last years there has been an increasing interest in psychiatric surveys as basis of epidemiologic studies and morbidity investigations. Numerous statistics from hospitals, from general psychiarists and general practioners have been referred to and constitute the basis for the 'Enquete zur Lage der Psychiatrie i...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1980-08-01 00:00:00
abstract：:A patient with chronic paranoid schizophrenia with delusions of infestation and of grandeur type, developed polydipsia in the course of his illness which ended up in acute life-threatening water intoxication. Apart from somatic causes like SIADH, which are discussed in literature, water-intoxication could psychodynami...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:An increase of intoxications in persons using psychoactive plants and mushrooms can be observed. Mainly adolescents are experimenting with this group of plants for its hallucinogenic effects and easy and cheap availability. A case of a toxic psychosis with hallucinations, disturbances of orientation and psychomotoric ...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章
doi：10.1055/s-2003-39490
更新日期：2003-05-01 00:00:00
abstract：:The planning of health care is primarily an administrative task. Service research supports the health administration in this task by supplying empirical data to objectify the need for care and ways to cater for that need. In this, service research on the one hand draws on descriptive and analytical data of epidemiolog...
journal_title：Psychiatrische Praxis
pub_type： 杂志文章,评审
doi：
更新日期：2000-09-01 00:00:00
