Characterization of karyotypic events and evolution in neuroblastoma.


BACKGROUND:Neuroblastoma (NB) is cytogenetically characterized by a number of non-random events. However, knowledge is limited concerning the timing of occurrence and inter-action of many of these events. METHODS:Karyotypic patterns were obtained from a study group of 49 NB tumors that had been analyzed by conventional cytogenetics combined with FISH and in some instances SKY. RESULTS:All chromosomes were involved in a numerical and structural aberration in at least one tumor. There was a positive correlation between the occurrence of MYCN and del(1p) and between del(1p) and 17q. Aberrations involving chromosomes X, 3, 19, and del(1p) could be considered early events, whereas those involving chromosomes 9, 13, 15, 18, 20, and 21 were often late events. CONCLUSIONS:This study suggests that the karyotypic patterns characterizing NB are complex. There are aberrations that can be grouped into early or late karyotypic events, but others, such as gain of 17q, are variable.


Pediatr Blood Cancer


Pediatric blood & cancer


Betts DR,Cohen N,Leibundgut KE,Kühne T,Caflisch U,Greiner J,Traktenbrot L,Niggli FK





Has Abstract


2005-02-01 00:00:00












  • Deficiencies in the Management of Iron Deficiency Anemia During Childhood.

    abstract::Limited high-quality evidence supports the management of iron deficiency anemia (IDA). To assess our institutional performance in this area, we retrospectively reviewed IDA treatment practices in 195 consecutive children referred to our center from 2006 to mid-2010. The majority of children were ≤4 years old (64%) and...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Powers JM,Daniel CL,McCavit TL,Buchanan GR

    更新日期:2016-04-01 00:00:00

  • Communication, Documentation, and Training Standards in Pediatric Psychosocial Oncology.

    abstract::As part of a larger effort to create standards for psychosocial care of children with cancer, we document consensus and evidence-based data on interprofessional communication, documentation, and training for professionals providing psycho-oncology services. Six databases were searched. Sixty-five articles and six guid...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Patenaude AF,Pelletier W,Bingen K

    更新日期:2015-12-01 00:00:00

  • DICER1 mutations in embryonal rhabdomyosarcomas from children with and without familial PPB-tumor predisposition syndrome.

    abstract::Embryonal rhabdomyosarcoma (ERMS) is the most common childhood sarcoma and is a component of the familial pleuropulmonary blastoma (PPB)-predisposition syndrome. Using the PPB model, we hypothesized that DICER1 mutations would be found in familial and sporadic forms of ERMS. Blood samples from four children with famil...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Doros L,Yang J,Dehner L,Rossi CT,Skiver K,Jarzembowski JA,Messinger Y,Schultz KA,Williams G,André N,Hill DA

    更新日期:2012-09-01 00:00:00

  • If only I could turn back time-Regret in bereaved parents.

    abstract:INTRODUCTION:Regret about loss is one of the most intense types of regret experienced in life. Little is known about the bereavement regret of parents whose child has died of cancer. Although knowledge about parents' experiences after their child's death is vital for supporting these families, parents' regret is mostly...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Sim CW,Heuse S,Weigel D,Kendel F

    更新日期:2020-06-01 00:00:00

  • Prevalence and predictors of anthracycline cardiotoxicity in children treated for acute myeloid leukaemia: retrospective cohort study in a single centre in the United Kingdom.

    abstract:BACKGROUND:Anthracycline cardiomyopathy is of concern in children treated for acute myeloid leukaemia (AML), but there are few data on the incidence and natural history of cardiotoxicity after AML treatment in the United Kingdom, where regimens have included high anthracycline exposure. PROCEDURE:Prevalence and predic...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Temming P,Qureshi A,Hardt J,Leiper AD,Levitt G,Ancliff PJ,Webb DK

    更新日期:2011-04-01 00:00:00

  • Concurrent radiation with irinotecan and carboplatin in intermediate- and high-risk rhabdomyosarcoma: a report on toxicity and efficacy from a prospective pilot phase II study.

    abstract:BACKGROUND:Irinotecan is highly active against rhabdomyosarcoma (RMS), yet its tolerability and efficacy in combination with radiation is unknown. We examined local control and toxicities in RMS patients treated with radiotherapy (RT) in combination with radiosensitizing agents irinotecan + carboplatin (I + C). PROCED...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Dharmarajan KV,Wexler LH,Wolden SL

    更新日期:2013-02-01 00:00:00

  • Deep intracranial extension of squamous cell carcinoma of the scalp.

    abstract::We report a case of recurrent squamous cell carcinoma (SCC) of the scalp with deep cerebral invasion in a 15-year-old girl. Plain films and CT showed extensive, full thickness, and skull destruction at the vertex. Gadolinium-enhanced MRI revealed neoplastic invasion of the meninges and both cerebral hemispheres down t...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Etlik O,Bay A,Izmirli M,Uğraş S,Yilmaz N,Turan A

    更新日期:2005-12-01 00:00:00

  • Delivery of radiation therapy in resource-limited settings: A pilot quality assessment study.

    abstract::Progress has been made in resource-limited countries in treating acute lymphoblastic leukemia, but advances in solid malignancies have been slower. Multidisciplinary care coordination is challenging, assessing adherence to guidelines through quality improvement initiatives is essential. We characterized deviations fro...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Power-Hays A,Friedrich P,Fernandez G,Cruz NA,Marcus K,Rodriguez-Galindo C,Collado L

    更新日期:2017-08-01 00:00:00

  • New targets for antibody therapy of pediatric B cell lymphomas.

    abstract::Antibody therapy has become standard of care for adult B cell lymphoma patients. It is a potentially less toxic and more targeted approach for lymphoma therapy and should therefore be applied to treat pediatric B cell lymphoma patients as well. In pediatric lymphoma patients, however, clinical experience with monoclon...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: van Vuren A,Meyer-Wentrup F

    更新日期:2014-12-01 00:00:00

  • Successful treatment of severe myasthenia gravis developed after allogeneic hematopoietic stem cell transplantation with plasma exchange and rituximab.

    abstract::Myasthenia gravis is among the rare complications after allogeneic hematopoietic stem cell transplantation and is usually associated with chronic GVHD. Herein, we report a 2-year and 10 months of age female with Griscelli syndrome, who developed severe myasthenia gravis at post-transplant +22nd month and required resp...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Unal S,Sag E,Kuskonmaz B,Kesici S,Bayrakci B,Ayvaz DC,Tezcan I,Yalnızoglu D,Uckan D

    更新日期:2014-05-01 00:00:00

  • Recognition of Li Fraumeni syndrome at diagnosis of a locally advanced extremity rhabdomyosarcoma.

    abstract::A contemporaneous presentation of a second breast cancer in a mother and an extremity rhabdomyosarcoma (RMS) in her daughter led to the diagnosis of the Li Fraumeni syndrome (LFS). Although the association between LFS and RMS in young patients is well recognised 1 there are no guidelines as to how this knowledge shoul...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Trahair T,Andrews L,Cohn RJ

    更新日期:2007-03-01 00:00:00

  • Parental Grief Following the Death of a Child from Cancer: The Ongoing Odyssey.

    abstract:BACKGROUND:The death of a child is a devastating event that results in profound grief and significant psychosocial and physical morbidities in parents. The parental grief journey is a complex phenomenon necessitating the utilization of newer models of bereavement with a focus on relationships and exploration of parents...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Snaman JM,Kaye EC,Torres C,Gibson D,Baker JN

    更新日期:2016-09-01 00:00:00

  • Nausea and vomiting in children and adolescents receiving intrathecal methotrexate: A prospective, observational study.

    abstract:BACKGROUND:The prevalence of nausea and vomiting after receipt of intrathecal methotrexate (IT-MTX) in pediatric oncology patients is unknown. METHODS:Patients (4-18 years) about to receive IT-MTX were eligible to participate in this prospective, observational study. Patients received antiemetics as prescribed by thei...

    journal_title:Pediatric blood & cancer

    pub_type: 评论,杂志文章


    authors: Flank J,Nadeem K,Moledina S,Khanna M,Schindera C,Punnett A,Dupuis LL

    更新日期:2017-10-01 00:00:00

  • Safety, efficacy, and pharmacokinetics of intravenous busulfan in children undergoing allogeneic hematopoietic stem cell transplantation.

    abstract:PURPOSE:To determine the safety, efficacy, and PK profile of intravenous busulfan (Bu) in the context of a Bu and cyclophosphamide (IVBuCy) preparative regimen in children undergoing allogeneic hematopoietic stem cell transplantation (HSCT). METHODS:Twenty-four children were enrolled in an open-label, multicenter tria...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Wall DA,Chan KW,Nieder ML,Hayashi RJ,Yeager AM,Kadota R,Przepiorka D,Mezzi K,Kletzel M,Pediatric Blood, Marrow Transplant Consortium.

    更新日期:2010-02-01 00:00:00

  • Glucocorticoid-Induced Proliferation in Untreated Pediatric Acute Myeloid Leukemic Blasts.

    abstract::We evaluated the in vitro glucocorticoid (GC) responsiveness of 117 pediatric acute myeloid leukemia cells by considering GC resistance, GC-induced proliferation, and GC-induced differentiation. None of the samples was highly GC sensitive, and only 15% were intermediately sensitive. GC-induced differentiation was not ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Klein K,Haarman EG,de Haas V,Zwaan ChM,Creutzig U,Kaspers GL

    更新日期:2016-08-01 00:00:00

  • Higher plasma asparaginase activity after intramuscular than intravenous Erwinia asparaginase.

    abstract::It is unclear if dosing intervals for Erwinase can be extended with intramuscular (i.m.) versus intravenous (i.v.) dosing. Children with acute lymphoblastic leukemia received Erwinase at 30 000-42 000 IU/m2 i.v. or i.m. I.m. Erwinase (n = 22) achieved activity above 0.1 IU/mL for longer than i.v. Erwinase (n = 33) (3....

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Panetta JC,Liu Y,Swanson HD,Karol SE,Pui CH,Inaba H,Jeha S,Relling MV

    更新日期:2020-07-01 00:00:00

  • Impact of SLCO1B1 521T > C variant on leucovorin rescue and risk of relapse in childhood acute lymphoblastic leukemia treated with high-dose methotrexate.

    abstract:BACKGROUND:Recent studies suggest that SLCO1B1 c.521T > C variant decreases the clearance of methotrexate (MTX) and elevates its plasma concentration, hence leucovorin doses may need to be adjusted. However, high leucovorin doses may affect the cure rate in childhood acute lymphoblastic leukemia (ALL). Hitherto neither...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Zhang HN,He XL,Wang C,Wang Y,Chen YJ,Li JX,Niu CH,Gao P

    更新日期:2014-12-01 00:00:00

  • The Italian consensus conference on the role of rehabilitation for children and adolescents with leukemia, central nervous system, and bone tumors, part 1: Review of the conference and presentation of consensus statements on rehabilitative evaluation of m

    abstract::Because of increasing survival rates in pediatric oncology, attention is focusing on cancer and its treatment-related side effects. Rehabilitation may reduce their impact. However, the literature does not provide strong evidence regarding rehabilitation pathways. Therefore, the Italian Association of Pediatric Hematol...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Rossi F,Ricci F,Botti S,Bertin D,Breggiè S,Casalaz R,Cervo M,Ciullini P,Coppo M,Cornelli A,Esposito M,Ferrarese M,Ghetti M,Longo L,Morri M,Naretto G,Orsini N,Fagioli F,AIEOP Rehabilitation Working Group Members.

    更新日期:2020-12-01 00:00:00

  • Magnetic resonance imaging in childhood leukemia survivors treated with cranial radiotherapy: a cross sectional, single center study.

    abstract:BACKGROUND:Children treated with cranial radiotherapy (CRT) for leukemia are at risk of developing central nervous system injuries. Magnetic resonance imaging (MRI) represents the examination method of choice for evaluating radiation-induced brain complications. The purpose of this report is to describe the spectrum of...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Faraci M,Morana G,Bagnasco F,Barra S,Polo P,Hanau G,Fioredda F,Caruso S,Rossi A,Spaziante R,Haupt R

    更新日期:2011-08-01 00:00:00

  • Mediastinal Germ Cell Tumors in Pediatric Patients: A Report From the Italian Association of Pediatric Hematology and Oncology.

    abstract:BACKGROUND:Primary mediastinal germ cell tumors (GCTs) are rare in children and still represent a challenge for both adult and pediatric oncologists because of their worse outcome compared to their gonadal counterpart. PROCEDURE:Prospectively collected data concerning patients enrolled in the Italian Association of Pe...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: De Pasquale MD,Crocoli A,Conte M,Indolfi P,D'Angelo P,Boldrini R,Terenziani M,Inserra A

    更新日期:2016-05-01 00:00:00

  • Relapse after localized rhabdomyosarcoma: Evaluation of the efficacy of second-line chemotherapy.

    abstract:PURPOSE:About one-third of patients with rhabdomyosarcoma relapse despite appropriate treatment and experience a poor outcome. Little meaningful improvement in the outcome of this disease has been observed over the last 30 years. There is no clear international recommendation concerning the use of salvage chemotherapy ...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Winter S,Fasola S,Brisse H,Mosseri V,Orbach D

    更新日期:2015-11-01 00:00:00

  • The burden of respiratory syncytial virus infections among children with sickle cell disease.

    abstract:BACKGROUND:Although respiratory syncytial virus (RSV) is the leading cause of pediatric lower respiratory tract infections, the burden of RSV in children with sickle cell disease (SCD) is unknown. METHODS:We conducted a retrospective, nested, case-control study of children with SCD <18 years who had respiratory viral ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Rostad CA,Maillis AN,Lai K,Bakshi N,Jerris RC,Lane PA,Yee ME,Yildirim I

    更新日期:2021-01-01 00:00:00

  • Lung metastases in neuroblastoma at initial diagnosis: A report from the International Neuroblastoma Risk Group (INRG) project.

    abstract:BACKGROUND:Neuroblastoma is the most common extracranial pediatric solid cancer. Lung metastasis is rarely detected in children with newly diagnosed neuroblastoma. We aimed to describe the incidence, clinical characteristics, and outcome of patients with lung metastasis at initial diagnosis using a large international ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Dubois SG,London WB,Zhang Y,Matthay KK,Monclair T,Ambros PF,Cohn SL,Pearson A,Diller L

    更新日期:2008-11-01 00:00:00

  • Access to specialized pediatric cancer care in Switzerland.

    abstract:BACKGROUND:Specialized pediatric cancer centers (PCCs) are thought to be essential to obtain state-of-the-art care for children and adolescents. We determined the proportion of childhood cancer patients not treated in a PCC, and described their characteristics and place of treatment. PROCEDURE:The Swiss Childhood Canc...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究


    authors: Adam M,von der Weid N,Michel G,Zwahlen M,Lutz JM,Probst-Hensch N,Niggli F,Kuehni C,Swiss Pediatric Oncology Group (SPOG).,Swiss Association of Cancer Registries (ASRT).

    更新日期:2010-05-01 00:00:00

  • Histologic survey of neuroblastomas after intensive induction chemotherapy.

    abstract:BACKGROUND:Histology after intensive induction chemotherapy is expected to become a beacon indicating when and how extensively radical surgery and lymph node dissection should be performed in advanced neuroblastoma. A thorough histologic review of surgical specimens was undertaken. PROCEDURE:All specimens from 34 pati...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Tsuchida Y,Miyauchi J,Kuroiwa M,Suzuki N,Sakamoto J,Suzuki M,Shitara T

    更新日期:2005-10-15 00:00:00

  • Hospital-based home care for children with cancer.

    abstract::Hospital-based home care (HBHC) is widely applied in Pediatric Oncology. We reviewed the potential effect of HBHC on children's physical health and risk of adverse events, parental and child satisfaction, quality of life of children and their parents, and costs. A search of PubMed, CINAHL, and EMBASE led to identifica...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Hansson H,Hallström I,Kjaergaard H,Johansen C,Schmiegelow K

    更新日期:2011-09-01 00:00:00

  • Immature platelet count: a simple parameter for distinguishing thrombocytopenia in pediatric acute lymphocytic leukemia from immune thrombocytopenia.

    abstract:BACKGROUND:Platelet counts below normal values define thrombocytopenia. However, platelet counts alone do not reveal the underlying pathomechanism. New blood cell counters provide additional information on platelet size and volume, and enable the distinction of sub-populations. In this preliminary study, we evaluate wh...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Strauss G,Vollert C,von Stackelberg A,Weimann A,Gaedicke G,Schulze H

    更新日期:2011-10-01 00:00:00

  • Weight and height in children newly diagnosed with cancer.

    abstract:BACKGROUND:Although weight loss and lack of linear growth occur in children with cancer, growth history is not included in research that aims to determine nutritional status in children newly diagnosed with cancer. Therefore, this study aimed to determine weight loss and lack of linear growth in this patient group. PR...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Brinksma A,Roodbol PF,Sulkers E,Hooimeijer HL,Sauer PJ,van Sonderen E,de Bont ES,Tissing WJ

    更新日期:2015-02-01 00:00:00

  • Paediatric malignant tumours of the gastrointestinal tract in the West Midlands, UK, 1957-2000: a large population based survey.

    abstract:BACKGROUND:To investigate the incidence, clinical characteristics and survival of malignant tumours of the gastrointestinal tract in children in the West Midlands in Britain over a 44-year span time, to identify any change over this period and to compare the data with the world literature. PROCEDURE:Retrospective popu...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Hameed R,Parkes S,Davies P,Morland BJ

    更新日期:2004-09-01 00:00:00

  • Treatment of Wilms tumor relapsing after initial treatment with vincristine and actinomycin D: a report from the National Wilms Tumor Study Group.

    abstract:PURPOSE:NWTS-5 was a multi-institutional clinical trial for patients less than 16 years of age at diagnosis with specific renal neoplasms who were diagnosed between August 1, 1995 and May 31, 2002. A uniform approach to the treatment of patients with relapse was employed. PATIENTS AND METHODS:Seventy-two patients who ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究


    authors: Green DM,Cotton CA,Malogolowkin M,Breslow NE,Perlman E,Miser J,Ritchey ML,Thomas PR,Grundy PE,D'Angio GJ,Beckwith JB,Shamberger RC,Haase GM,Donaldson M,Weetman R,Coppes MJ,Shearer P,Coccia P,Kletzel M,Macklis R,To

    更新日期:2007-05-01 00:00:00