Abstract:
:Triptans are not widely used in clinical practice despite their well-established efficacy, endorsement by the US Headache Consortium, and the demonstrable need to employ effective intervention to reduce migraine-associated disability. Although the relatively restricted use of triptans may be attributed to several factors, research suggests that prescribers' concerns about cardiovascular safety prominently figure in limiting their use. This article reviews clinical data--including results of clinical trials, postmarketing studies and surveillance, and pharmacodynamic studies--relevant to assessing the cardiovascular safety profile of the triptans. These data demonstrate that triptans are generally well tolerated. Chest symptoms occurring during use of triptans are usually nonserious and usually not attributed to ischemia. Incidence of triptan-associated serious cardiovascular adverse events in both clinical trials and clinical practice appears to be extremely low. When they do occur, serious cardiovascular events have most often been reported in patients at significant cardiovascular risk or in those with overt cardiovascular disease. Adverse cardiovascular events also have occurred, however, in patients without evidence of cardiovascular disease. Several lines of evidence suggest that nonischemic mechanisms are responsible for sumatriptan-associated chest symptoms, although the mechanism of chest symptoms has not been determined to date. Importantly, most of the clinical trials and clinical practice data on triptans are derived from patients without known cardiovascular disease. Therefore, the conclusions of this review cannot be extended to patients with cardiovascular disease. The cardiovascular safety profile of triptans favors their use in the absence of contraindications.
journal_name
Headachejournal_title
Headacheauthors
Dodick DW,Martin VT,Smith T,Silberstein Sdoi
10.1111/j.1526-4610.2004.04105.xkeywords:
subject
Has Abstractpub_date
2004-05-01 00:00:00pages
S20-30eissn
0017-8748issn
1526-4610pii
HED04105journal_volume
44 Suppl 1pub_type
杂志文章,评审相关文献
HEADACHE文献大全abstract:BACKGROUND:Patients with chronic kidney disease who need dialysis often have poor quality of life. Dialysis headache is a frequent complication of hemodialysis and is often a challenge for nephrologists, neurologists, and headache specialists. METHOD:This was a narrative review. RESULTS:The prevalence of dialysis hea...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12875
更新日期:2017-01-01 00:00:00
abstract:OBJECT:To investigate the rhythmicity of migraine episodes without aura in a pediatric population. METHODS:Time of occurrence of 2517 migraine attacks in 115 children was recorded, by means of a diary, both by hourly and monthly intervals. RESULTS:A significant circadian variation, characterized by a peak in the afte...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2006.00613.x
更新日期:2006-11-01 00:00:00
abstract::Significant progress in molecular genetics has advanced our understanding of the genetic basis of migraine. The fundamentals of molecular genetics, and the recent advances in the field, are important for clinicians to understand, as they provide a foundation for critical appraisal of the literature, unprecedented insi...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12156
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:To compare the relative tolerability of 5-HT1B/1D agonists and to investigate the relationships (if any) among systemic exposure, lipophilicity, and clinical tolerability for 5-HT1B/1D agonists. METHODS:Post hoc correlations were sought among the following variables: absolute dose (= administered dose x ora...
journal_title:Headache
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:In previous studies, pregnancy has been associated with less headache, but the influence of parity on this association is largely unknown. OBJECTIVES:To examine the prevalence of headache and migraine among pregnant women, and explore the relation of headache to parity in a large, population-based study. M...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2009.01438.x
更新日期:2009-06-01 00:00:00
abstract::The case of a 53-year-old woman is described, who since the age of 38 years had been suffering from a unilateral headache that was at first remitting, but then evolved into an unremitting course. The headache was burning in quality, located in the left forehead and face, and was accompanied by mild ipsilateral autonom...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1992.hed3201039.x
更新日期:1992-01-01 00:00:00
abstract::Migraine is a chronic recurrent disorder with episodic manifestations that is progressive in some individuals. Migraine progresses clinically, physiologically, and anatomically. Progression may be a consequence of the mechanisms that generate the migraine attacks (eg, cortical spreading depression) or it may be a func...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/j.1526-4610.2007.00969.x
更新日期:2008-01-01 00:00:00
abstract::Two patients suffering from SUNCT syndrome are presented. Some features are remarkable. The first patient was a 69-year-old man whose first crisis was located in the right supraorbital region. After a 4-month spontaneous remission, the pain returned to the upper part of the cheek, radiating to the supraciliary region ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1998.3805369.x
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Language disturbances have been previously described as word-finding difficulties in epileptic patients. These disturbances have been recently reported in migraineurs in treatment with topiramate but they have never been defined and assessed in these patients with the aid of neuropsychological testing. OBJE...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2007.00860.x
更新日期:2008-01-01 00:00:00
abstract::The history of post-traumatic headache begins in the middle of the 19th century, and its latest iteration has been defined in the International Headache Classification of 2004. Contrary to the latter, there are instances when mild head injury without symptoms or signs of concussion may evoke the pathophysiological cha...
journal_title:Headache
pub_type: 历史文章,杂志文章
doi:10.1111/j.1526-4610.2009.01462.x
更新日期:2009-07-01 00:00:00
abstract::Migraine and stroke are the most common neurovascular disorders affecting adults. Migraine, particularly with aura, is associated with increased stroke risk both during and between attacks; as such, migraine may be viewed as a potentially modifiable risk factor for stroke. The exact mechanism by which migraine can pre...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12115
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:It is commonly known that headaches are induced by intake of specific food, drink, and/or additive. In addition, some patients experience postprandial headache independent of ingestion of specific items. Currently, information on the pathophysiology underlying this particular type of headache is scarce. CAS...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.13136
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:Migraine is associated with several important visual symptoms, during both acute attacks and headache-free intervals. The purpose of this investigation was to use validated vision-related quality of life instruments to assess the effect of migraine on visual quality of life. BACKGROUND:Many migraineurs exper...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.13330
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To investigate whether intravenously infused provokes migraine aura and migraine headache in migraine patients with aura. BACKGROUND:Migraine with aura has been associated with endothelial dysfunction and increased stroke risk. The initiating mechanism of migraine aura symptoms is not known. Experimental pro...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.13753
更新日期:2020-04-01 00:00:00
abstract::The ergot alkaloids are a family of chemical entities that have many pharmacologic effects. Their diversity results from their interaction with multiple receptors, their variable receptor affinity and intrinsic activity, and their variable organ-specific receptor access. Ergotamine tartrate (ET) was one of the first e...
journal_title:Headache
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To describe the relationship between mood/anxiety disorders and migraine headaches emphasizing the frequency of episodes based in a cross-sectional analysis in the Brazilian Longitudinal Study of Adult Health. BACKGROUND:It has been suggested that frequency of migraine headaches can be directly associated wi...
journal_title:Headache
pub_type: 杂志文章,多中心研究
doi:10.1111/head.12397
更新日期:2014-09-01 00:00:00
abstract::The drug discovery programs that led to the development of the triptans were determined by the membership of the American Headache Society to be the most important breakthrough in headache medicine in the last 50 years. Dr. Humphrey, who spearheaded the drug discovery, recounts the pioneering work that took place and ...
journal_title:Headache
pub_type: 历史文章,杂志文章
doi:10.1111/j.1526-4610.2008.01097.x
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:A recent study conducted in triptan-naive migraine patients showed that tolerability was the second most important attribute of an acute treatment. However, the proportion of patients reporting side effects after any acute treatment may vary with regard to the method of assessment. OBJECTIVES:To contrast tw...
journal_title:Headache
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1526-4610.2004.04191.x
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:Ophthalmoplegic migraine (OM) is a rare disorder characterized by recurrent oculomotor nerve palsy in children, following migraine headaches. We report 62 adults, seen consecutively, who developed acute ophthalmoplegia with severe attacks of migraine over a 10-year (1996-2005) period. An overwhelming majority...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2009.01405.x
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To describe the statuslike pattern of SUNCT (short-lasting unilateral neuralgiform pain with conjunctival injection and tearing) in two young women. BACKGROUND:SUNCT syndrome is a rare condition characterized by a short-lasting periocular pain associated with marked autonomic symptoms. Twenty-five cases have...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2001.01151.x
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:To determine the pain intensity of cluster headache through a large survey by comparing it to other painful disorders. Furthermore, to investigate the relationship between maximal pain, autonomic, and other clinical symptoms, as well as demographic attributes of cluster headache. BACKGROUND:The pain of clust...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.14021
更新日期:2020-12-18 00:00:00
abstract::We studied 11 patients undergoing a routine lumbar puncture to determine if there were cerebrospinal fluid leaks at the puncture site and whether the maximum volume of leakage correlates with a lumbar puncture headache. Patients completed a headache questionnaire before and after the lumbar puncture. Limited magnetic ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1995.hed3507420.x
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:Migraine has been reported as a possible risk factor for ischemic stroke. The mechanisms underlying this association are unknown. OBJECTIVES:To evaluate cerebrovascular reactivity to hypercapnia in the anterior and posterior circulation of patients with migraine, as reduced cerebrovascular reactivity is ass...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2004.04006.x
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the safety and efficacy of ketamine-magnesium combination to reduce attacks in a series of patients with refractory chronic cluster headache (rCCH). BACKGROUND:Refractory chronic cluster headache (CCH) is a rare but highly debilitating condition that needs new treatment options. A previous publi...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.14005
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To determine the brain structures involved in mediating the pain of hemicrania continua using positron emission tomography. BACKGROUND:Hemicrania continua is a strictly unilateral, continuous headache of moderate intensity, with superimposed exacerbations of severe intensity that are accompanied by trigemina...
journal_title:Headache
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1526-4610.2004.04141.x
更新日期:2004-09-01 00:00:00
abstract::Headache centers have to deal with patients suffering from headache induced by chronic substance use which is a well-recognized complication of migraine treatment. The objective of this study was to compare psychiatric comorbidity between migraineurs with and without chronic substance use: 34 migrainous inpatients wit...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1999.3907477.x
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Headache is commonly reported in patients presenting with orofacial pain. It has only recently been demonstrated that headache-related disability is high in orofacial pain patients. Traumatic life events (TLEs) such as sexual abuse, physical abuse, and post-traumatic stress disorder (PTSD) are also common in...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2008.01182.x
更新日期:2009-04-01 00:00:00
abstract::Orthostatic headache is a key symptom of intracranial hypotension; however, not all orthostatic headaches are caused by cerebrospinal fluid leaks leading to intracranial hypotension. We report here the unusual case of a 68-year-old man presenting with orthostatic headache in which compression of the C3 spinal nerve ro...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2007.00982.x
更新日期:2008-01-01 00:00:00
abstract::This study examined the relationship between the menstrual cycle, the stress process, and migraines. Women migraineurs (N = 12) and a matched control sample (N = 12) completed a set of questionnaires assessing stress, appraisal, and coping at premenses, menses, and ovulation. In addition, migraineurs completed a month...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1996.3609531.x
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of migraine and episodic tension-type headache (ETTH) among university students as well as its impact on academic performance and quality of life. BACKGROUND:Headache is a very common symptom in clinical practice. The reduced capacities due to migraine can be profound, and more st...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2001.041007710.x
更新日期:2001-07-01 00:00:00