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Seasonal fluctuations of androgen-binding activity in the testis of the frog, Rana esculenta.

Abstract：

:An androgen-binding activity has been identified in nuclear extracts of the testis of the frog, Rana esculenta. A single class of high affinity (Kd = 2.5 +/- 0.6 x 10(-9) M), low-capacity binding sites was found. The binding was specific for androgens; 17 beta-estradiol displaced [3H]testosterone with an ID50 of 0.1 microM. Cytosolic binding activity has a low affinity and a high capacity and lacks specificity. The seasonal fluctuations in binding capacity did not correlate with the androgen peaks in plasma and testes between February and June and in September; periods coinciding with the resumption of spermatogenesis and the development of spermatids, respectively. The present data strongly support androgenic control of intratesticular function in vertebrates generally.

journal_name

Gen Comp Endocrinol

journal_title

General and comparative endocrinology

authors

Paolucci M,D'Antonio M,Pierantoni R

doi

10.1016/0016-6480(92)90228-c

keywords:

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

335-40

issue

3

eissn

0016-6480

issn

1095-6840

journal_volume

88

pub_type

杂志文章

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