Studies of fibrinogen binding to platelets by flow cytometry: an improved method for studies of platelet activation.

abstract：:Mice with a total deficiency in blood coagulation Factor X (FX) were generated by targeted replacement of an 18-kb fragment of the FX gene, comprising all exons encoding the mature FX protein, with a neo(r) cassette. The genotype distribution among the offspring from heterozygous breeding pairs suggested that FX defic...

journal_title：Thrombosis and haemostasis

authors： Dewerchin M,Liang Z,Moons L,Carmeliet P,Castellino FJ,Collen D,Rosen ED

更新日期：2000-02-01 00:00:00

abstract：:Advanced glycation end-products (AGEs) interact with their receptor RAGE, leading to an inflammatory state. We investigated the role of RAGE in postischaemic leukocyte adhesion after myocardial infarction and its effect on postischaemic myocardial function. Wildtype (WT), ICAM-1-/-, RAGE-/- or ICAM-1/RAGE-/- mice unde...

journal_title：Thrombosis and haemostasis

authors： Ziegler T,Horstkotte M,Lange P,Ng J,Bongiovanni D,Hinkel R,Laugwitz KL,Sperandio M,Horstkotte J,Kupatt C

更新日期：2016-08-01 00:00:00

abstract：:Undoubtedly, platelets are key elements in the regulation of thrombosis and haemostasis. Along with their primary task to prevent blood loss from injured vessels, platelets have emerged as regulators of a variety of processes in the vasculature. Multiple challenges, from the contact and adhesion to subendothelial matr...

journal_title：Thrombosis and haemostasis

authors： von Hundelshausen P,Petersen F,Brandt E

更新日期：2007-05-01 00:00:00

abstract：:Data on anti-platelet therapy (APT) for prevention of atherothrombotic events in thrombocytopaenic cancer patients is lacking. We aimed to identify patient and physician characteristics associated with APT management in thrombocytopaenic patients with haematological malignancy. A clinical vignette-based experiment was...

journal_title：Thrombosis and haemostasis

authors： Leader A,Ten Cate V,Ten Cate-Hoek AJ,Spectre G,Beckers EAM,Raanani P,Giaccherini C,Pereg D,Schouten HC,Falanga A,Ten Cate H

更新日期：2019-01-01 00:00:00

abstract：:Lenalidomide, a derivate of thalidomide, has recently been approved in Europe for the treatment of patients with multiple myeloma. Although the substance has a better effect/side-effect profile, especially with regard to teratogenicity and neurotoxicity, the rate of therapy-induced thrombosis seems comparable to thali...

journal_title：Thrombosis and haemostasis

authors： Gieseler F

更新日期：2008-06-01 00:00:00

abstract：:Noninvasive diagnosis of deep vein thrombosis (DVT) is based on ultrasound examination of the leg veins, usually restricted to only compression of the proximal veins (CUS). Patients with negative CUS findings require a second examination or a combination with other tests, which impairs clinical efficiency. In this pro...

journal_title：Thrombosis and haemostasis

authors： Schellong SM,Schwarz T,Halbritter K,Beyer J,Siegert G,Oettler W,Schmidt B,Schroeder HE

更新日期：2003-02-01 00:00:00

abstract：:In consecutive patients with suspected venous thromboembolism the interobserver variability of the SimpliRED D-dimer test was evaluated by two observers who independently scored one plate, the between assay variation was performed simultaneously by a third independent observer, who assessed a second plate. The biologi...

journal_title：Thrombosis and haemostasis

authors： Turkstra F,van Beek EJ,Büller HR

更新日期：1998-01-01 00:00:00

abstract：:Microangiopathy and disseminated platelet aggregation have been reported in thrombotic thrombocytopenic purpura (TTP) and pregnancy-induced hypertension (PIH). Since unusually large von Willebrand factor (vWF) multimers have been implicated in the evolvement of TTP, we analyzed factor VIII/vWF parameters in patients w...

journal_title：Thrombosis and haemostasis

authors： Brenner B,Zwang E,Bronshtein M,Seligsohn U

更新日期：1989-09-29 00:00:00

abstract：:At the moment of hemostasis, the platelet must be able to reorganize its cytoskeleton through a complexly orchestrated signaling cascade that is regulated, in part, by polyphosphoinositides. In the past 6 years, evidence has accumulated that PH domains bind these polyphosphoinositides and play a role in cytoskeletal c...

journal_title：Thrombosis and haemostasis

authors： Ma AD,Abrams CS

更新日期：1999-08-01 00:00:00

abstract：:Diabetic subjects have been shown to have altered fibrin network structures. One possible cause may be fibrinogen glycation resulting in altered structure/function properties. We investigated the effect of glucose control on fibrinogen glycation and fibrin network structure in type 2 diabetes. Blood samples were taken...

journal_title：Thrombosis and haemostasis

authors： Pieters M,Covic N,Loots du T,van der Westhuizen FH,van Zyl DG,Rheeder P,Jerling JC,Weisel JW

更新日期：2006-11-01 00:00:00

abstract：:The effect of selective activation of platelet prostaglandin (PG) E2 receptor subtype EP2 or EP4 on platelet aggregation remains to be determined. In platelets prepared from wild-type mice (WT platelets), high concentrations of PGE2 inhibited platelet aggregation induced by U-46619, a thromboxane receptor agonist. How...

journal_title：Thrombosis and haemostasis

authors： Kuriyama S,Kashiwagi H,Yuhki K,Kojima F,Yamada T,Fujino T,Hara A,Takayama K,Maruyama T,Yoshida A,Narumiya S,Ushikubi F

更新日期：2010-10-01 00:00:00

abstract：:ADP plays a crucial role in haemostasis and thrombosis and its receptors are potential targets for antithrombotic drugs. Two G-protein coupled P2 receptors contribute to platelet aggregation: the P2Y1 receptor initiates aggregation through mobilisation of calcium stores, while the more recently identified P2Y12 recept...

journal_title：Thrombosis and haemostasis

authors： Gachet C

更新日期：2001-07-01 00:00:00

abstract：:When adenosine diphosphate (ADP) is added to hirudinized platelet-rich plasma (PRP) in which the level of platelet cAMP has been pharmacologically elevated, there is an initial rapid fall in the level of cAMP brought about by inhibition of adenylate cyclase. This may be followed by a subsequent activation of adenylate...

journal_title：Thrombosis and haemostasis

authors： Glenn JR,Heptinstall S

更新日期：1998-08-01 00:00:00

abstract：:Isolated rat hepatocytes possess per cell 4,500 high-affinity binding sites for thrombin with a Kd of 30-40 pM, and 2.8 X 10(5) low-affinity sites with a Kd of 30 nM. These binding sites are highly specific for thrombin. Half-maximal binding of 125I-labelled thrombin is achieved after 3 min at 37 degrees C and 7 min a...

journal_title：Thrombosis and haemostasis

authors： Weyer B,Petersen TE,Sonne O

更新日期：1988-12-22 00:00:00

abstract：:In a preceding paper the baseline data in the Münster Arteriosclerosis Study (PROCAM study) of the levels of fibrinogen, factor VIIc and factor VIIIc were described, and their correlation of age, body weight, smoking, alcohol, pill-using and menopause discussed. In this part the relationship of these coagulation facto...

journal_title：Thrombosis and haemostasis

authors： Balleisen L,Assmann G,Bailey J,Epping PH,Schulte H,van de Loo J

更新日期：1985-10-30 00:00:00

abstract：:A collaborative study has been organised by NIBSC to examine the performance of FIXa assays between laboratories, and to investigate the need for a standard. Ampoules of 3 materials, one monocomponent concentrate (coded C) and 2 different preparations of purified human FIXa (one proposed reference preparation, coded A...

journal_title：Thrombosis and haemostasis

authors： Gray E,Walker D,Heath A,Barrowcliffe TW

更新日期：1996-12-01 00:00:00

abstract：:Residual venous obstruction (RVO) in patients with previous deep vein thrombosis (DVT) of the lower limbs has been suggested as an independent risk factor for recurrent venous thromboembolism (VTE). RVO could be a marker of a persistent prothrombotic state. We have compared the rate of RVO in patients with DVT and a p...

journal_title：Thrombosis and haemostasis

authors： Galli M,Ageno W,Squizzato A,Dentali F,Manfredi E,Steidl L,Venco A

更新日期：2005-07-01 00:00:00

abstract：:We performed a prospective study in 86 consecutive patients with central vein catheter-related deep venous thrombosis (DVT) of the upper extremity, to evaluate the prevalence of pulmonary embolism (PE), and to identify clinical variables that would increase the likelihood of developing PE in an individual patient. Sin...

journal_title：Thrombosis and haemostasis

authors： Monreal M,Raventos A,Lerma R,Ruiz J,Lafoz E,Alastrue A,Llamazares JF

更新日期：1994-10-01 00:00:00

abstract：:Increased plasma plasminogen activator inhibitor-1 (PAI-1) has been implicated in the development of vascular disease. In type 2 diabetes mellitus high PAI-1 levels are associated with increased plasma concentrations of free fatty acids (FFA) and triacylglycerol indicating an association or a causal relationship. To a...

journal_title：Thrombosis and haemostasis

authors： Krebs M,Geiger M,Polak K,Vales A,Schmetterer L,Wagner OF,Waldhäusl W,Binder BR,Roden M

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND: This study assessed changes in anticoagulation therapy over time in patients with atrial fibrillation (AF). METHODS: Analyses were performed on a claims-based dataset of 4 million health-insured individuals. The study population consisted of patients newly initiating a non-vitamin-K oral anticoagulants (NO...

journal_title：Thrombosis and haemostasis

authors： Hohnloser SH,Basic E,Nabauer M

更新日期：2019-06-01 00:00:00

abstract：:We studied the role of various markers of lipid metabolism, hemostasis and inflammation in a two year follow-up of 3,000 patients with angina pectoris, during which time 106 patients experienced myocardial infarction or sudden coronary death. Low levels of high density lipoprotein (HDL) cholesterol and of apolipoprote...

journal_title：Thrombosis and haemostasis

authors： Bolibar I,von Eckardstein A,Assmann G,Thompson S,ECAT Angina Pectoris Study Group. European Concerted Action on Thrombosis and Disabilities.

更新日期：2000-12-01 00:00:00

abstract：:The pathogenesis of abdominal aortic aneurysm (AAA) involves a central component of chronic inflammation which is predominantly mediated by myeloid cells. We hypothesized that the local inflammatory activity may be reflected in systemic alterations of neutrophil and monocyte populations as well as in soluble factors o...

journal_title：Thrombosis and haemostasis

authors： Zagrapan B,Eilenberg W,Prausmueller S,Nawrozi P,Muench K,Hetzer S,Elleder V,Rajic R,Juster F,Martelanz L,Hayden H,Klopf J,Inan C,Teubenbacher P,Weigl MP,Kirchweger P,Beitzke D,Jilma B,Wojta J,Bailey MA,Scott DJA,

更新日期：2019-05-01 00:00:00

abstract：:The development of antibodies against infused factor VIII (FVIII) in patients with haemophilia A is a serious complication leading to poorly controlled bleeding and increased morbidity. No treatment has been proven to reduce high titre antibodies in patients who fail immune tolerance induction or are not candidates fo...

journal_title：Thrombosis and haemostasis

authors： Leissinger C,Josephson CD,Granger S,Konkle BA,Kruse-Jarres R,Ragni MV,Journeycake JM,Valentino L,Key NS,Gill JC,McCrae KR,Neufeld EJ,Manno C,Raffini L,Saxena K,Torres M,Marder V,Bennett CM,Assmann SF

更新日期：2014-09-02 00:00:00

abstract：:The effect of negatively-charged polymers, used in some artificial devices, on plasma clotting and kinin systems was studied in vitro using polyelectrolyte complexes. Contact activation was observed as an immediate, transient and surface-dependent phenomenon. After incubation of the plasma with the polymer a small dec...

journal_title：Thrombosis and haemostasis

authors： Boffa MC,Dreyer B,Pusineri C

更新日期：1984-02-28 00:00:00

abstract：:The Ig-ITIM superfamily member, PECAM-1 acts as a negative regulator of ITAM-signalling pathways in platelets involving GPVI/FcR gamma chain and Fc?RIIa. This negative feedback loop involves regulation of collagen and GPVI-dependent aggregation events, platelet-thrombus-growth on immobilised collagen under flow and Fc...

journal_title：Thrombosis and haemostasis

authors： Sardjono CT,Harbour SN,Yip JC,Paddock C,Tridandapani S,Newman PJ,Jackson DE

更新日期：2006-12-01 00:00:00

abstract：:Seasonal variation in venous thromboembolism (VTE) risk in individuals with familial predisposition to VTE has not been explored. This nationwide study aimed to determine whether there are age- and sex-specific seasonal differences in risk of hospitalisation of VTE among individuals with and without a family history o...

journal_title：Thrombosis and haemostasis

authors： Zöller B,Li X,Ohlsson H,Sundquist J,Sundquist K

更新日期：2013-12-01 00:00:00

abstract：:Gender and the 4G/5G polymorphism in the plasminogen activator inhibitor 1 (PAI-1) gene are believed to play a role in the regulation of plasma PAI-1 activity. Adipose tissue has been found to be an important source of PAI-1. The possible influence of gender and the 4G/5G polymorphism in the PAI-1 gene on PAI-1 secret...

journal_title：Thrombosis and haemostasis

authors： van Harmelen V,Wahrenberg H,Eriksson P,Arner P

更新日期：2000-02-01 00:00:00

abstract：:We developed an ELISA test to measure the binding of plasma von Willebrand factor (vWF) to arterial microfibrils and compared this interaction to the binding of vWF to collagen under the same conditions. We found that vWF binds to microfibrils in a similar manner as it binds to collagen: the binding was independent of...

journal_title：Thrombosis and haemostasis

authors： Fauvel-Lafève F,Legrand YJ

更新日期：1990-08-13 00:00:00

abstract：:Inhibition of adenylate cyclase in intact platelets by addition of compounds such as 2', 5' - dideoxyadenosine prevented the inhibition of platelet aggregation by PGE1 but did not affect the responses of platelets to aggregating agents in the absence of PGE1. This confirms that cyclic AMP mediates the effects of PGE1 ...

journal_title：Thrombosis and haemostasis

authors： Haslam RJ,Davidson MM,Fox JE,Lynham JA

更新日期：1978-10-31 00:00:00

abstract：:Lysyl oxidase (LOX) is an extracellular matrix-modifying enzyme that seems to play a critical role in vascular remodelling. However, the lack of viable LOX-deficient animal models has been an obstacle to deep in LOX biology. In this study we have developed a transgenic mouse model that over-expresses LOX in vascular s...

journal_title：Thrombosis and haemostasis

authors： Orriols M,Guadall A,Galán M,Martí-Pàmies I,Varona S,Rodríguez-Calvo R,Briones AM,Navarro MA,de Diego A,Osada J,Martínez-González J,Rodríguez C

更新日期：2014-10-01 00:00:00