Effects of continuous positive airway pressure/positive end-expiratory pressure and pressure-support ventilation on work of breathing, using an animal model.

Abstract:

OBJECTIVE:Evaluate the effects of continuous positive airway pressure (CPAP)/positive end-expiratory pressure (PEEP) and pressure support ventilation (PSV) on work of breathing (WOB). METHODS:With 13 anesthetized lambs we measured WOB with an esophageal balloon and flow signals. All the animals were sedated, intubated, and ventilated, using 2 pediatric ventilators (Servo 300 and VIP Bird). Ventilator settings were CPAP of 0, 5, and 10 cm H(2)O and PSV of 5 and 10 cm H(2)O with PEEP of 0, 5, and 10 cm H(2)O. Data were analyzed with 2-way analysis of variance. RESULTS:With the Servo 300 the total WOB (WOB(T)) increased between CPAP/PEEP of 0 and 10 cm H(2)O (p

journal_name

Respir Care

journal_title

Respiratory care

authors

Heulitt MJ,Holt SJ,Wilson S,Hall RA

keywords:

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

689-96

issue

7

eissn

0020-1324

issn

1943-3654

journal_volume

48

pub_type

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