Abstract：
BACKGROUND:Healthy individuals without respiratory symptoms can sometimes present with low FEV1/FVC. The objective of this study was to characterize and compare subjects without symptoms and with reduced FEV1/FVC but normal FEV1 with subjects with mild obstructive lung disease. METHODS:Fifty healthy subjects with FEV1/FVC below the fifth percentile of reference values (normal variants) were compared with 52 subjects with asthma and 48 subjects with COPD who had similar FEV1/FVC. RESULTS:Subjects without symptoms were more likely to be male, younger, and taller, and to have higher FVC%, FEV1%, mid expiratory flow, and terminal flow than subjects with obstructive disease. A receiver operating characteristic curve analysis determined that the best separation between the groups was provided by age < 55 y, height ≥ 167 cm, and FVC > 105%. A logistic regression analysis confirmed that male sex, age, FVC%, and FEF75 (Forced expiratory flow in 75% of forced vital capacity) were significant factors for discriminating subjects without symptoms from those with obstructive lung disease. CONCLUSIONS:A reduced FEV1/FVC may be a normal finding in younger-to-middle age male subjects with an FVC% value above the mean predicted value, especially when terminal flow is within the normal range.
journal_name
Respir Carejournal_title
Respiratory careauthors
Dos Santos Andreata L,Soares MR,Pereira CAdoi
10.4187/respcare.06131subject
Has Abstractpub_date
2019-05-01 00:00:00pages
570-575issue
5eissn
0020-1324issn
1943-3654pii
respcare.06131journal_volume
64pub_type
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