Abstract:
:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic lung disease with no clear etiology and few therapeutic options. Growth factors that act as mediators in the development of this disease might be important therapeutic targets. Nintedanib is a triple-tyrosine kinase inhibitor and a potent antagonist of growth factors such as platelet-derived growth factor, vascular endothelial growth factor, and basic fibroblast growth factor, and it is currently evaluated in clinical trials as a potential IPF therapy. Treatment with nintedanib may slow decline in lung function, decrease the frequency of exacerbations, and improve quality of life in subjects with IPF. This observation, together with extensive safety and pharmacokinetic data from studies of nintedanib in malignancy, led the way for the clinical development of this drug in IPF. Observations from clinical trials, together with the preclinical data, suggest that nintedanib may become an important therapeutic option for individuals with IPF. High-dose nintedanib improved the quality of life, slowed the progression of lung fibrosis and the decline of lung function, and reduced the rate of exacerbations in individuals with mild and moderate IPF. This is a short review based on the available data (September 2013) on nintedanib.
journal_name
Respir Carejournal_title
Respiratory careauthors
Dimitroulis IAdoi
10.4187/respcare.03023subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1450-5issue
9eissn
0020-1324issn
1943-3654pii
respcare.03023journal_volume
59pub_type
杂志文章,评审相关文献
Respiratory Care文献大全abstract::Helium is an inert gas with a very low density (0.18 g/L), which allows it to pass through narrowed passages with less turbulence than nitrogen or oxygen. For many years, helium-oxygen mixture (heliox) has been used for patients with severe airway obstruction. However, the data supporting the clinical application of h...
journal_title:Respiratory care
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
abstract:INTRODUCTION:Patients receiving invasive mechanical ventilation with an endotracheal tube (ETT) can often benefit from pharmaceutical aerosols; however, drug delivery through the ventilator circuit is known to be very inefficient. The objective of this study was to improve the delivery of aerosol through an invasive me...
journal_title:Respiratory care
pub_type: 杂志文章
doi:10.4187/respcare.02782
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:In the context of increasing attention to medical errors, missed therapies have become a subject of focus both for optimizing clinical care and for assuring appropriate institutional performance during external review by accrediting bodies. Because the issue of missed treatments in respiratory therapy has re...
journal_title:Respiratory care
pub_type: 杂志文章
doi:
更新日期:2003-02-01 00:00:00
abstract:INTRODUCTION:Automatic tube compensation (ATC), a new ventilation mode that compensates for the work of breathing imposed by endotracheal tube resistance, recently became commercially available. METHODS:We conducted a laboratory study with a lung model and a Nellcor Puritan Bennett 840 ventilator to compare ATC and pr...
journal_title:Respiratory care
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::This review explains the fundamentals of electrostatic spray (electrospray) atomization, with emphasis on operation in the so called cone-jet mode, which produces droplets with a very narrow size distribution. Since the control of droplet size is key to maximizing distal lung deposition, the electrospray should be wel...
journal_title:Respiratory care
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::Mechanically ventilated patients in respiratory failure often require adjunct therapies to address special needs such as inhaled drug delivery to alleviate airway obstruction, treat pulmonary infection, or stabilize gas exchange, or therapies that enhance pulmonary hygiene. These therapies generally are supportive in ...
journal_title:Respiratory care
pub_type: 杂志文章,评审
doi:10.4187/respcare.02217
更新日期:2013-06-01 00:00:00
abstract::Respiratory volume monitoring (RVM) has been developed to noninvasively measure minute ventilation (V̇E), tidal volume, and breathing frequency and to display real-time respiratory curves in nonintubated patients. Although RVM was originally developed for post-anesthesia and monitored anesthesia care, we describe 3 ap...
journal_title:Respiratory care
pub_type: 杂志文章
doi:10.4187/respcare.03744
更新日期:2015-05-01 00:00:00
abstract::A summary of the 2-day Journal Conference on Current Trends in Neonatal and Pediatric Respiratory Care is provided. Topics included: diagnosis and management of common respiratory disorders of infants and children such as asthma, respiratory syncytial virus bronchiolitis, and cystic fibrosis; and common pediatric resp...
journal_title:Respiratory care
pub_type:
doi:
更新日期:2003-04-01 00:00:00
abstract::Three devices used to humidify the air delivered to hospitalized patients were evaluated for their relative hazard as measured by the concentration of bacterial output delivered with the gas. Two of the devices were evaporative types (commonly called "humidifiers"), moisturizing with water vapor, while the third was a...
journal_title:Respiratory care
pub_type: 杂志文章
doi:
更新日期:1979-03-01 00:00:00
abstract::Mass-care events, such as pandemic influenza, could reach such devastating proportions that there will be the need to make difficult triage decisions that will ultimately result in the deaths or severe disability of patients in large numbers. The method by which we determine how triage of scarce health care resources ...
journal_title:Respiratory care
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract::Explaining the meaning of the results to the reader is the purpose of the discussion section of a research paper. There are elements of the discussion that should be included and other things that should be avoided. Always write the discussion for the reader; remember that the focus should be to help the reader unders...
journal_title:Respiratory care
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:The utilization of checklists, bundles, and protocols attempts to provide standardization in the delivery of patient care. Despite important progress obtained in the prevention of hospital-acquired infections, the daily management of mechanical ventilation is still prone to heterogeneity, depending on the nu...
journal_title:Respiratory care
pub_type: 杂志文章
doi:10.4187/respcare.03887
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To describe the self-expanding endobronchial occluder, as utilized in bronchoscopic lung volume reduction, with a 36 month follow-up procedure. METHODS:Twenty-three subjects with severe emphysema were recruited and underwent flexible bronchoscopic placement of self-expanding endobronchial occluders. Outcomes...
journal_title:Respiratory care
pub_type: 杂志文章
doi:10.4187/respcare.02218
更新日期:2013-08-01 00:00:00
abstract::Long-term oxygen therapy (LTOT) improves survival for patients afflicted with severe chronic obstructive pulmonary disease and may also reduce the incidence of repeat hospitalization due to exacerbations. When properly dosed and titrated, LTOT has also been shown to improve exercise tolerance, thereby enhancing the ov...
journal_title:Respiratory care
pub_type: 杂志文章
doi:
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Microalbuminuria, used as a marker of endothelial dysfunction, is a predictor of mortality for any reason and of cardiovascular events. Recent research on the management of COPD has focused more on comorbidities, including cardiovascular events. The objective of this study was to investigate the incidence of...
journal_title:Respiratory care
pub_type: 杂志文章
doi:10.4187/respcare.05168
更新日期:2017-03-01 00:00:00
abstract::In 2002 the National Asthma Education and Prevention Program published evidence-based guidelines for the diagnosis and management of asthma, but there are some unresolved asthma-management issues that need further research. For asthmatic children inhaled corticosteroids are more beneficial than as-needed use of beta(2...
journal_title:Respiratory care
pub_type: 杂志文章,评审
doi:
更新日期:2004-07-01 00:00:00
abstract::Mechanical ventilation alarms and alerts, both audible and visual, provide the clinician with vital information about the patient's physiologic condition and the status of the machine's function. Not all alarms generated by the mechanical ventilator provide actionable information. Over time, clinicians can become dese...
journal_title:Respiratory care
pub_type: 杂志文章,评审
doi:10.4187/respcare.06878
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Confirmation of endotracheal tube (ETT) tip position and timely identification and correction of malposition is an essential component of care for endotracheally intubated and mechanically ventilated children. We evaluated the ability of a prototype optoacoustic medical device to determine ETT tip position. ...
journal_title:Respiratory care
pub_type: 杂志文章
doi:10.4187/respcare.06140
更新日期:2018-12-01 00:00:00
abstract::In patients with ventilator-associated pneumonia, systemic use of antibiotics is the cornerstone of medical management. Supplemental use of aerosolized antibiotics with intravenous antibiotics in both experimental and clinical studies has been shown to have the following pharmacologic benefits: (1) aerosolized antibio...
journal_title:Respiratory care
pub_type: 杂志文章,评审
doi:10.4187/respcare.04748
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Studies on the submaximal aerobic capacity of exclusive narghile smokers (ENS) seem necessary in view of effective prevention of cardiorespiratory diseases. The goal of the study was to assess, by 6-min walk test (6MWT) data, the submaximal aerobic capacity of ENS, to identify factors influencing their 6-min...
journal_title:Respiratory care
pub_type: 杂志文章
doi:10.4187/respcare.03058
更新日期:2014-11-01 00:00:00
abstract::End-stage liver disease and its complications are a leading cause of death among adults in the United States, and thousands of patients await liver transplantation. The liver plays a central role in health and homeostasis and thus the diseased liver leads to many deleterious effects on multiple organ systems, includin...
journal_title:Respiratory care
pub_type: 杂志文章,评审
doi:
更新日期:2007-08-01 00:00:00
abstract::Although appropriate antibiotics may improve survival in patients with bacterial pneumonia, use of empirical broad-spectrum antibiotics in patients without infection is potentially harmful, facilitating colonization and superinfection with multiresistant microorganisms. Invasive diagnostic methods, including bronchoal...
journal_title:Respiratory care
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Evaluate the effects of continuous positive airway pressure (CPAP)/positive end-expiratory pressure (PEEP) and pressure support ventilation (PSV) on work of breathing (WOB). METHODS:With 13 anesthetized lambs we measured WOB with an esophageal balloon and flow signals. All the animals were sedated, intubated...
journal_title:Respiratory care
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::We report the first successful use of venovenous extracorporeal membrane oxygenation (ECMO) for refractory respiratory failure in an infant with DiGeorge anomaly, following thymus transplantation. A 23-month-old female with complete immune-incompetent DiGeorge anomaly 65 days after allogenic thymus transplantation was...
journal_title:Respiratory care
pub_type: 杂志文章
doi:10.4187/respcare.01051
更新日期:2011-06-01 00:00:00
abstract::A 20-year-old man was admitted in the neurology ICU after the drainage of a large frontal hematoma related to the spontaneous bleeding of a recently diagnosed cavernoma. On admission the Glasgow coma score was 4/15, with evidence of sub-falcorial herniation and elevated intracranial pressure. On the 4th postoperative...
journal_title:Respiratory care
pub_type: 杂志文章
doi:10.4187/respcare.01322
更新日期:2012-07-01 00:00:00
abstract:UNLABELLED:Because of the temperature extremes encountered during emergency resuscitation and transport in the field, we sought to evaluate the performance and safety of 10 adult resuscitators (5 permanent units: Hope 4, Laerdal, Lifesaver, Mark 3, and PMR; and 5 disposable units: BagEasy, Code Blue, CPR Bag, DMR, and ...
journal_title:Respiratory care
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract::Dieulafoy disease of the bronchus is a rare condition. A 28-y-old male patient with recurrent exacerbations of hemoptysis (producing up to 300 mL) over the previous 4 y was admitted to our hospital following an acute episode. A 3-mm sessile lesion covered with somewhat ulcerated smooth mucosa was detected at the dista...
journal_title:Respiratory care
pub_type: 杂志文章
doi:10.4187/respcare.03307
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:There is no published standard for the ratio of staff to patients during exercise sessions in outpatient pulmonary rehabilitation. This lack of a standard raises concern about patient safety and the ability to monitor patients adequately. OBJECTIVE:Determine a staff-to-patient ratio standard by examining ...
journal_title:Respiratory care
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
abstract::Understanding the transport and deposition of inhaled aerosols is of fundamental importance to inhalation therapy. Herein we address issues that affect drug delivery from experimental and theoretical perspectives. Accordingly, we shall limit our comments to a focused review of laboratory work (ie, an in vitro perspect...
journal_title:Respiratory care
pub_type: 杂志文章,评审
doi:
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:The value of impulse oscillometry (IOS) for bronchial provocation testing is poorly defined. We investigated the positive threshold derived from the parameters and diagnostic power of IOS for asthma with the leukotriene D(4) bronchial provocation test. METHODS:We enrolled 62 subjects with asthma and 21 heal...
journal_title:Respiratory care
pub_type: 杂志文章
doi:10.4187/respcare.02417
更新日期:2013-12-01 00:00:00