Dynamical synaptic plasticity: a model and connection to some experiments.

Abstract:

:Using a modified version of a phenomenological model for the dynamics of synaptic plasticity, we examine some recent experiments of Wu et al. [(2001) J Physiol 533:745-755]. We show that the model is quantitatively consistent with their experimental protocols producing long-term potentiation (LTP) and long-term depression (LTD) in slice preparations of rat hippocampus. We also predict the outcome of similar experiments using different frequencies and depolarization levels than reported in their results.

journal_name

Biol Cybern

journal_title

Biological cybernetics

authors

Whitehead A,Rabinovich MI,Huerta R,Zhigulin VP,Abarbanel HD

doi

10.1007/s00422-002-0376-4

keywords:

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

229-35

issue

3

eissn

0340-1200

issn

1432-0770

journal_volume

88

pub_type

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