Abstract:
:Sexually mature male guppies (Poecilia reticulata) were exposed to 17beta-estradiol, 4-tert-octylphenol, bisphenol A, flutamide, p,p'-DDE, or vinclozolin to determine the effects of these estrogenic or antiandrogenic substances on the testis structure. Flutamide, p,p'-DDE, 4-tert-octylphenol, and bisphenol A exposure caused similar effects. These included a reduced number of spermatogenetic cysts and an increased number of spermatozeugmata in the ducts. These effects are indicative of a blocked spermatogonial mitosis. 17beta-Estradiol produced effects different from those of the other compounds studied. The effects were seen as an increased number of hypertrophied Sertoli cells/efferent duct cells. The mammalian antiandrogen vinclozolin had no observable effects on the testis structure when given in doses of 1, 10, or 100 microg/mg food.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Kinnberg K,Toft Gdoi
10.1016/s0147-6513(02)00010-6keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
16-24issue
1eissn
0147-6513issn
1090-2414pii
S0147651302000106journal_volume
54pub_type
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