Clostridium sordellii phospholipase C: gene cloning and comparison of enzymatic and biological activities with those of Clostridium perfringens and Clostridium bifermentans phospholipase C.

abstract：:We investigated the effect of an extract from a helminth (Ascaris suum) in zymosan-induced arthritis (ZYA) or collagen-induced arthritis (CIA). Rats and mice, respectively, received 1 mg and 0.1 mg zymosan intra-articularly (i.a.). Test groups received an A. suum extract either per os (p.o.) or intraperitoneally (i.p....

journal_title：Infection and immunity

authors： Rocha FA,Leite AK,Pompeu MM,Cunha TM,Verri WA Jr,Soares FM,Castro RR,Cunha FQ

更新日期：2008-06-01 00:00:00

abstract：:An effective vaccine for Vibrio cholerae is not yet available for use in the developing world, where the burden of cholera disease is highest. Characterizing the proteins that are expressed by V. cholerae in the human host environment may provide insight into the pathogenesis of cholera and assist with the development...

journal_title：Infection and immunity

authors： LaRocque RC,Krastins B,Harris JB,Lebrun LM,Parker KC,Chase M,Ryan ET,Qadri F,Sarracino D,Calderwood SB

更新日期：2008-09-01 00:00:00

abstract：:Cells of the marine fish pathogen Vibrio anguillarum 775 harboring a plasmid associated with virulence can grow unaffected in the presence of iron-binding compounds such as transferrin. In contrast, the growth of isogenic plasmidless derivatives is inhibited by the presence of iron chelators. Radioactive from (55Fe3+)...

journal_title：Infection and immunity

authors： Crosa JH,Hodges LL

更新日期：1981-01-01 00:00:00

abstract：:Phagocytosis and mechanisms of killing of Aspergillus fumigatus conidia by murine alveolar macrophages (AM), which are the main phagocytic cells of the innate immunity of the lung, were investigated. Engulfment of conidia by murine AM lasts 2 h. Killing of A. fumigatus conidia by AM begins after 6 h of phagocytosis. S...

journal_title：Infection and immunity

authors： Philippe B,Ibrahim-Granet O,Prévost MC,Gougerot-Pocidalo MA,Sanchez Perez M,Van der Meeren A,Latgé JP

更新日期：2003-06-01 00:00:00

abstract：:Infection with Histoplasma capsulatum results in a subclinical infection in immunocompetent hosts due to an effective cellular immune response. By contrast, immunodeficient individuals can have a severe disseminated and potentially fatal disease. In a previous study, it was demonstrated that normal mice infected intra...

journal_title：Infection and immunity

authors： Zhou P,Sieve MC,Tewari RP,Seder RA

更新日期：1997-03-01 00:00:00

abstract：:Nonimmune binding of immunoglobulin to whole bacteria was quantitated for North American isolates of Haemophilus somnus recovered from cattle with pneumonia, reproductive failure (abortion), or thromboembolic meningoencephalitis or from the vagina or prepuce of carrier cattle. Quantitative binding activity covered a w...

journal_title：Infection and immunity

authors： Widders PR,Dorrance LA,Yarnall M,Corbeil LB

更新日期：1989-02-01 00:00:00

abstract：:The bacterial pathogen Burkholderia pseudomallei invades host cells, escapes from endocytic vesicles, multiplies intracellularly, and induces the formation of actin tails and membrane protrusions, leading to direct cell-to-cell spreading. This study was aimed at the identification of B. pseudomallei genes responsible ...

journal_title：Infection and immunity

authors： Pilatz S,Breitbach K,Hein N,Fehlhaber B,Schulze J,Brenneke B,Eberl L,Steinmetz I

更新日期：2006-06-01 00:00:00

abstract：:Brucella abortus is a class III zoonotic bacterial pathogen able to survive and replicate inside host cells, including macrophages. Here we report a multidimensional transposon sequencing analysis to identify genes essential for Brucella abortus growth in rich medium and replication in RAW 264.7 macrophages. The const...

journal_title：Infection and immunity

authors： Sternon JF,Godessart P,Gonçalves de Freitas R,Van der Henst M,Poncin K,Francis N,Willemart K,Christen M,Christen B,Letesson JJ,De Bolle X

更新日期：2018-07-23 00:00:00

abstract：:Controversy persists over the role that the capsular polysaccharide plays in the pathogenesis of Staphylococcus aureus infections. To address this issue, we compared the mouse virulence of S. aureus Reynolds and capsule-defective mutant strains cultivated under conditions of high or low capsule expression. Strain Reyn...

journal_title：Infection and immunity

authors： Thakker M,Park JS,Carey V,Lee JC

更新日期：1998-11-01 00:00:00

abstract：:Ocular exposure of mice to live elementary bodies of Chlamydia trachomatis serovar A results in immunological sensitization of the mice. This reactivity is manifested by the development of early (5 h) and delayed-type (24 h) dermal reactivity and serovar-specific antibody formation against either live or irradiated (1...

journal_title：Infection and immunity

authors： Colley DG,Goodman TG,Barsoum IS

更新日期：1986-10-01 00:00:00

abstract：:This study investigates the role of CD4+ T cells in host defense against cholera enterotoxin-induced diarrhea. Antitoxin immunoglobulin A formation and gut protection against cholera toxin (CT) following oral immunizations with CT were evaluated in normal mice and mice that had been depleted of CD4+ T cells by in vivo...

journal_title：Infection and immunity

authors： Hörnqvist E,Goldschmidt TJ,Holmdahl R,Lycke N

更新日期：1991-10-01 00:00:00

abstract：:Differences in infection kinetics and host response between Burkholderia multivorans and Burkholderia cenocepacia were demonstrated in a pulmonary infection model in BALB/c mice. B. multivorans persisted in the lung, while B. cenocepacia was cleared. Indirect immunofluorescence and electron microscopy of B. multivoran...

journal_title：Infection and immunity

authors： Chu KK,MacDonald KL,Davidson DJ,Speert DP

更新日期：2004-10-01 00:00:00

abstract：:This study was carried out to determine the role of nitric oxide (NO) in Staphylococcus aureus infection in mice. NO production in spleen cell cultures was induced by heat-killed S. aureus. Expression of mRNA of the inducible isoform of NO synthase (iNOS) was induced in the spleens and kidneys of S. aureus-infected mi...

journal_title：Infection and immunity

authors： Sasaki S,Miura T,Nishikawa S,Yamada K,Hirasue M,Nakane A

更新日期：1998-03-01 00:00:00

abstract：:A 30-amino-acid peptide corresponding to variable domain IV (VD IV) of the major outer membrane protein of Chlamydia trachomatis serovar E was conjugated to keyhole limpet hemocyanin (KLH) and used to immunize mice. The resulting antisera (anti-KLH-VD IV sera) recognized all 15 serovars of C. trachomatis when assayed ...

journal_title：Infection and immunity

authors： Cheng X,Pal S,de la Maza LM,Peterson EM

更新日期：1992-08-01 00:00:00

abstract：:Humoral immune responses in experimental African trypanosomiasis were assessed in rabbits infected with Trypanosoma rhodesiense. Immune complexes as measured by a Clq binding assay or a Clq solid-phase assay were detected by day 10 and increased progressively through day 28. Immune complexes analyzed by double diffusi...

journal_title：Infection and immunity

authors： Lindsley HB,Janecek LL,Gilman-Sachs AM,Hassanein KM

更新日期：1981-08-01 00:00:00

abstract：:Two distinct types of granulomas were produced in the draining lymph nodes by immunizing guinea pigs with Mycobacterium bovis BCG or Mycobacterium leprae, as reported earlier (Narayanan et al., J. Pathol. 134:253-265, 1981). In the BCG-induced granuloma there is successful containment, killing, and degradation of the ...

journal_title：Infection and immunity

authors： Mathew RC,Katayama I,Gupta SK,Curtis J,Turk JL

更新日期：1983-01-01 00:00:00

abstract：:We compared the immune defense of mice with chronic granulomatous disease (CGD mice) with that of wild-type C57BL/6 mice for their response to Sporothrix schenckii. A subcutaneous injection of 5 x 10(4) CFU S. schenckii strain IFM41598 into CGD mice resulted in systemic infection and death within 84 days. In contrast,...

journal_title：Infection and immunity

authors： Kajiwara H,Saito M,Ohga S,Uenotsuchi T,Yoshida S

更新日期：2004-09-01 00:00:00

abstract：:Cimetidine is a powerful H2 receptor antagonist that eliminates histamine's effects on chemotaxis, phagocytosis, and superoxide anion production by phagocytes. The purpose of this study was to analyze the clinical and histopathological changes associated with experimental periodontitis in rabbits in response to topica...

journal_title：Infection and immunity

authors： Hasturk H,Kantarci A,Ebrahimi N,Andry C,Holick M,Jones VL,Van Dyke TE

更新日期：2006-04-01 00:00:00

abstract：:Escherichia coli strain RDEC-1 causes a diarrheagenic infection in rabbits with AF/R1 fimbriae, which have been identified as an important colonization factor in RDEC-1 adherence leading to disease. The AF/R1-mediated RDEC-1 adherence model has been used as a model systems for E. coli diarrheal diseases. In this study...

journal_title：Infection and immunity

authors： Ryu H,Kim YS,Grange PA,Cassels FJ

更新日期：2001-02-01 00:00:00

abstract：:The extracellular adherence protein (Eap) is a multifunctional Staphylococcus aureus protein and broad-spectrum adhesin for several host matrix and plasma proteins. We investigated the interactions of full-length Eap and five recombinant tandem repeat domains with host proteins by use of surface plasmon resonance (BIA...

journal_title：Infection and immunity

authors： Hussain M,Haggar A,Peters G,Chhatwal GS,Herrmann M,Flock JI,Sinha B

更新日期：2008-12-01 00:00:00

abstract：:Intestinal epithelial activation of nuclear factor kappa B (NF-κB) exerts both detrimental and beneficial functions in response to various luminal insults, including ones associated with mucosa-associated pathogens. Gastrointestinal infection with enteropathogenic Escherichia coli (EPEC) causes severe injuries in epit...

journal_title：Infection and immunity

authors： Choi HJ,Kim J,Do KH,Park SH,Moon Y

更新日期：2013-06-01 00:00:00

abstract：:Neisseria meningitidis is the causative agent of meningococcal disease. Onset of meningococcal disease can be extremely rapid and can kill within a matter of hours. However, although a much-feared pathogen, Neisseria meningitidis is frequently found in the nasopharyngeal mucosae of healthy carriers. The bacterial fact...

journal_title：Infection and immunity

authors： Ren X,MacKichan JK

更新日期：2014-12-01 00:00:00

abstract：:The genetics of resistance to a naturally occurring respiratory infection caused by Sendai virus was examined in F1, F2, and backcross progeny of resistant C57BL/6J and susceptible DBA/2J mice and in 25 recombinant inbred strains. An intranasal inoculum of 0.1 50% tissue culture infective dose (low dose) of Sendai vir...

journal_title：Infection and immunity

authors： Brownstein DG

更新日期：1983-07-01 00:00:00

abstract：:Despite effective antimicrobial chemotherapy, control of Chlamydia trachomatis urogenital infection will likely require a vaccine. We have assessed the protective effect of an outer membrane protein-based vaccine by using a murine model of chlamydial genital infection. Female mice were first vaccinated with Chlamydia ...

journal_title：Infection and immunity

authors： Farris CM,Morrison SG,Morrison RP

更新日期：2010-10-01 00:00:00

abstract：:Streptococcus pneumoniae is a fermentative microorganism and causes serious diseases in humans, including otitis media, bacteremia, meningitis, and pneumonia. However, the mechanisms enabling pneumococcal survival in the host and causing disease in different tissues are incompletely understood. The available evidence ...

journal_title：Infection and immunity

authors： Gaspar P,Al-Bayati FA,Andrew PW,Neves AR,Yesilkaya H

更新日期：2014-12-01 00:00:00

abstract：:Chronic helminth infections are known to be associated with the modulation of antigen-specific T-cell responses. Strongyloides stercoralis infection is characterized by the downmodulation of antigen-specific Th1 and Th17 responses and the upregulation of Th2 and Th9 responses. Immune homeostasis is partially maintaine...

journal_title：Infection and immunity

authors： Rajamanickam A,Munisankar S,Dolla C,Nutman TB,Babu S

更新日期：2019-11-18 00:00:00

abstract：:A battery of lymphoid and nonlymphoid cells was examined for susceptibility to lysis by natural killer cells of chickens. Several susceptible targets were recognized, and most susceptible among these were cells of line LSCC-RP9, derived from a lymphoid tumor induced by Rous-associated virus 2. The natural killer react...

journal_title：Infection and immunity

authors： Sharma JM,Okazaki W

更新日期：1981-03-01 00:00:00

abstract：:Vibrio cholerae accessory colonization factor genes (acfA, B, C, and D) are required for efficient intestinal colonization. Expression of acf genes is under the control of a regulatory cascade that also directs the synthesis of cholera toxin and proteins involved in the biogenesis of the toxin-coregulated pilus. The g...

journal_title：Infection and immunity

authors： Everiss KD,Hughes KJ,Kovach ME,Peterson KM

更新日期：1994-08-01 00:00:00

abstract：:Binding of the complement-downregulating protein factor H (fH) to the surface of the meningococcus is important for survival of the organism in human serum. The meningococcal vaccine candidate factor H binding protein (fHbp) is an important ligand for human fH. While some fHbp-specific monoclonal antibodies (MAbs) blo...

journal_title：Infection and immunity

authors： Giuntini S,Reason DC,Granoff DM

更新日期：2011-09-01 00:00:00

abstract：:Streptococcus mutans is one of the best-known biofilm-forming organisms associated with humans. We investigated the role of the sortase gene (srtA) in monospecies biofilm formation and observed that inactivation of srtA caused a decrease in biofilm formation. Genes encoding three putative sortase-dependent proteins we...

journal_title：Infection and immunity

authors： Lévesque CM,Voronejskaia E,Huang YC,Mair RW,Ellen RP,Cvitkovitch DG

更新日期：2005-06-01 00:00:00