Black-white differences in tumor grade (aggressiveness) at diagnosis of prostate cancer, 1992-1998.

Abstract:

OBJECTIVES:To compare recent temporal trends in the proportion of high-grade (less differentiated, or more "aggressive") prostate cancers for Blacks (African Americans) and Whites. Reports of Black-White differences have generated speculation that genetic factors could be involved. METHODS:The study included all 126,889 non-Hispanic White and 20,247 Black patients with prostate cancer diagnosed in 1992-1998 and reported to the US National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) Program of population-based cancer registries. RESULTS:Overall and stage-specific Black-White differences in proportion of high-grade cancers were not large and declined over time (especially among elderly patients). By 1998, the adjusted odds ratio for high (vs other known) grade was not statistically significant for Black vs White elderly patients when age and stage at diagnosis were included in a multiple logistic regression model. CONCLUSIONS:These data provide little justification for speculation about a genetic basis for a higher proportion of aggressive prostate cancer among Black patients. Trends in Black-White differences in the frequency of high-grade cancer suggest Black-White differences in trends in prostate cancer screening rates (especially in the elderly), which require further investigation.

journal_name

Ethn Dis

journal_title

Ethnicity & disease

authors

Polednak AP

keywords:

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

536-40

issue

4

eissn

1049-510X

issn

1945-0826

journal_volume

12

pub_type

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