Abstract:
:This study assesses the occurrence of and identifies clinical characteristics associated with the development of aberrant conduction during infusion of the I(kr)-blocker almokalant. Class III drugs may induce aberrant conduction by prolongation of cardiac repolarization, especially during atrial fibrillation (AF). Ninety-two patients with AF received a 6-hour almokalant infusion, aiming at conversion to sinus rhythm (SR). Fiftyfive of the patients received an identical infusion during SR. During almokalant infusion, the number of patients with intermittent QRS aberration during AF increased, from 21% to 80% at rest, and was further increased to 89% during exercise, with predominantly left, and sequential bilateral, bundle branch aberrancy. Patients with aberrant conduction showed signs of more advanced myocardial disease. Predictors of the development of QRS aberration were female gender, arrhythmia duration, and decreased left ventricular ejection fraction, while use of calcium antagonists decreased the probability. No patient showed aberration during regular SR. Twenty-one patients experienced aberrantly conducted supraventricular premature beats. In conclusion, aberrant conduction is common during infusion of the I(kr)-blocker almokalant during AF, and seems to be more frequent in females and in patients with more advanced myocardial disease.
journal_name
J Electrocardioljournal_title
Journal of electrocardiologyauthors
Houltz B,Darpö B,Crijns HJ,Swedberg K,Blomström P,Jensen SM,Svernhage E,Edvardsson Ndoi
10.1054/jelc.2002.33766keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
201-12issue
3eissn
0022-0736issn
1532-8430pii
S0022073602000031journal_volume
35pub_type
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:
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abstract:BACKGROUND:Hibernating myocardium develops inhomogeneity in myocardial sympathetic innervation with spontaneous sudden cardiac death (SCD) because of ventricular fibrillation (VF). The triggers and prodromal arrhythmias initiating SCD in this substrate are unknown. METHODS:Swine chronically instrumented with a proxima...
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pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2006.05.026
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journal_title:Journal of electrocardiology
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doi:10.1016/s0022-0736(82)81002-9
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
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journal_title:Journal of electrocardiology
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doi:10.1016/j.jelectrocard.2019.06.010
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2007.02.002
更新日期:2007-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2020.11.016
更新日期:2020-12-03 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jelectrocard.2007.06.021
更新日期:2007-11-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2014.02.006
更新日期:2014-05-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/0022-0736(91)90010-j
更新日期:1991-04-01 00:00:00
abstract:OBJECTIVE:Assess effect of right ventricular pacing (RVP) on left ventricular (LV) activation in heart failure patients with left bundle branch block (LBBB). BACKGROUND:LV activation during RVP is regarded as similar to LBBB; hence novel CRT algorithms may avoid RVP by adopting "fusion" pacing with intrinsic RBB-media...
journal_title:Journal of electrocardiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.jelectrocard.2014.09.002
更新日期:2015-01-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/0022-0736(88)90105-7
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Simulation of the electrical activation of the heart and its comparison with real in vivo activation is a promising method in testing potential determinants of excitation. Simulation of the electrical activity of the human heart is now emerging as a step forward for understanding and predicting electrophysio...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2008.12.008
更新日期:2009-03-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jelectrocard.2015.12.007
更新日期:2016-03-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(88)80023-2
更新日期:1988-01-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2017.08.032
更新日期:2018-01-01 00:00:00
abstract::QT and RR intervals' fluctuations are implicated in the development of malignant arrhythmias. Recent research has quantified repolarization lability using stochastic and linear methods. However, QT-RR intervals are nonlinearly coupled. To this end, QT and RR intervals were extracted from twenty four patients with acut...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2004.04.008
更新日期:2004-07-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2010.07.013
更新日期:2010-11-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2007.11.004
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2010.08.008
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journal_title:Journal of electrocardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jelectrocard.2008.06.016
更新日期:2008-11-01 00:00:00
abstract::The vectorcardiographic basis of indeterminate QRS axis has not been elucidated. Accordingly, Frank lead VCGs were obtained on ten consecutive subjects with biphasic QRS complexes in the six extremity leads. The frontal plane vector in each case showed a very narrow loop inscribed in a symmetrical fashion around the E...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(82)80022-8
更新日期:1982-01-01 00:00:00
abstract::Sintered Ag-AgCl needle electrodes were used to record unipolar directly coupled (DC) electrograms transmurally from right and left ventricular myocardium. Direct coupling yields unfiltered low-frequency signal content, preserving repolarization waveform morphology. These electrograms were analyzed using completely au...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/0022-0736(88)90102-1
更新日期:1988-08-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2019.05.005
更新日期:2019-01-01 00:00:00
abstract::Junctional ectopic tachycardia(JET) is a rare childhood arrhythmia originating from the area adjacent to the atrioventricular(AV) node. It often occurs after surgical procedures like repair of Tetralogy of Fallot, atrioventricular septal defect and ventricular septal defect, which are all performed in that area. While...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2017.01.015
更新日期:2017-01-01 00:00:00
abstract::In eighteen patients with atrioventricular conduction disturbance, His bundle electrograms were studied via the arm vein. A 6F Berkovits-Castellanos USCI hexapolar electrode catheter was introduced into the right atrium and looped across the tricuspid valve in a "golf club" shape. The main aim was to leave the two dis...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(81)80046-5
更新日期:1981-01-01 00:00:00
abstract::The authors present a patient who initially underwent anterior approach atrioventricular (AV) nodal modification for treatment of typical AV junctional reentrant tachycardia (AVJRT) and subsequently developed clinical episodes of a previously undocumented type of supraventricular tachycardia. Findings during electroph...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(05)80113-x
更新日期:1994-01-01 00:00:00
abstract::Central venous catheters extending into intracardiac chambers can provoke premature atrial and ventricular complexes, which have been reported to initiate supraventricular tachyarrhythmias. These catheters are traditionally placed via the femoral, subclavian, or internal jugular veins. A new alternative to the convent...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(96)80116-6
更新日期:1996-01-01 00:00:00
abstract::Unexplained sudden deaths following use of pentavalent antimonial drugs have been described, presumably owing to ventricular arrhythmias. A patient is reported with QT interval prolongation and syncopal episodes related to torsade de pointes following treatment of visceral leishmaniasis with meglumine antimoniate. Thi...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(97)80023-4
更新日期:1997-04-01 00:00:00