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Amyloid-beta peptide is toxic to neurons in vivo via indirect mechanisms.

Abstract：

:We have studied the neurotoxicity of amyloid-beta (Abeta) after a single unilateral intravitreal injection. Within the retina apoptotic cells were seen throughout the photoreceptor layer and the inner nuclear layer but not in the ganglion cell layer at 48 h after injection of Abeta(1-42) compared to vehicle control and control peptide. At 5 months, there was a significant reduction in total cell numbers in the ganglion cell layer in Nissl stained retinas. There was glial cell dysfunction with upregulation of glial fibrillary acidic protein and a reduction in the expression of Müller cell associated proteins in the injected retinas. These results suggest an indirect cytotoxic effect of Abeta on retinal neurons and an important role for dysfunction of Müller glia in mediating Abeta neurotoxicity.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Walsh DT,Montero RM,Bresciani LG,Jen AY,Leclercq PD,Saunders D,EL-Amir AN,Gbadamoshi L,Gentleman SM,Jen LS

doi

10.1006/nbdi.2002.0485

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

20-7

issue

1

eissn

0969-9961

issn

1095-953X

pii

S0969996102904857

journal_volume

10

pub_type

杂志文章

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