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BDNF regulates the expression of fragile X mental retardation protein mRNA in the hippocampus.

Abstract：

:Both fragile X mental retardation protein (FMRP) and brain-derived neurotrophic factor (BDNF) are implicated in the maturation of neurons and in the higher cognitive functions. We have investigated whether FMRP and BDNF are reciprocally regulated in neurons. Exposure of cultured hippocampal neurons to BDNF, but not to NT-3, reduced FMR1 mRNA levels to 84.8% of control at 4 h and the levels were back to baseline by 24 h or 4 days. Furthermore, expression of FMR1 mRNA was reduced (82.4% of control) in vivo in the hippocampus of transgenic mice overexpressing TrkB receptors, and a small but significant (5.1%) decrease was also detected in FMRP protein levels. In contrast, the expression patterns of BDNF and TrkB mRNAs were not altered in FMRP-deficient mice compared to wild-type mice. Our data provide evidence that BDNF via TrkB signaling decreases FMRP expression and suggest a role for FMRP in BDNF-induced synaptic plasticity.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Castrén M,Lampinen KE,Miettinen R,Koponen E,Sipola I,Bakker CE,Oostra BA,Castrén E

doi

10.1006/nbdi.2002.0544

keywords:

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

221-9

issue

1

eissn

0969-9961

issn

1095-953X

pii

S0969996102905449

journal_volume

11

pub_type

杂志文章

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