Corticotropin-releasing factor antagonist attenuates stress-induced inhibition of seasonal ovarian recrudescence in the lizard Mabuya carinata.


:Whether administration of the corticotropin-releasing factor (CRF) antagonist alpha-helical CRF(9-41) (hCRF) prevents stress response of the ovary, the oviduct, the adrenals, and the spleen was studied in the lizard Mabuya carinata. Stressors (handling, chasing, and noise) applied randomly, five times a day, for 1 month to lizards during the recrudescence phase of the ovarian cycle caused a significant increase in mean nuclear diameter of the adrenal cortical cells and a significant reduction in mean number of islands of white pulp in the spleen. These results, albeit indirectly, indicated an activation of the adrenal gland and immune suppression. There was a significant decrease in the mean relative weight of the ovary and the oviduct and in the mean number of oocytes and the primordial follicles compared to those of controls. Furthermore, vitellogenic follicles were absent in the ovary of lizards exposed to stressors in contrast to their presence in controls. However, administration of hCRF to the lizards exposed to stressors (stress + hCRF) resulted in vitellogenesis and follicular growth. The mean relative weight of the ovary and the oviduct and the mean number of oocytes and the primordial follicles in stress + hCRF-treated lizards were significantly higher than those in the lizards exposed to stressors, whereas they did not significantly differ from those of controls. The results indicate that hCRF attenuates stress-induced inhibition of ovarian follicular and oviductal development in M. carinata. To the best of our knowledge, this is the first report revealing that CRF antagonist can prevent ovarian stress response in lower vertebrates.


Gen Comp Endocrinol


Ganesh CB,Yajurvedi HN





Has Abstract


2002-04-01 00:00:00














  • Immunoreactive gonadotropin-releasing hormone-like material in the brain and the pituitary gland during the periovulatory period in the brown trout (Salmo trutta L.): relationships with the plasma and pituitary gonadotropin.

    abstract::In fish there are few data on the gonadotropin-releasing hormone (Gn-RH) neurosecretory activity, which could explain long- and short-term variations of the gonadotropin secretion. There is no biological species specificity between mammal and fish Gn-RH; although there is a structural difference, they are, on the cont...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Breton B,Motin A,Billard R,Kah O,Geoffre S,Precigoux G

    更新日期:1986-01-01 00:00:00

  • Characterization of spermatogonial cells and niche in the scorpion mud turtle (Kinosternon scorpioides).

    abstract::Undifferentiated spermatogonia (Aund) or spermatogonial stem cells (SSCs) are committed to the establishment and maintenance of spermatogenesis and fertility throughout a male's life and are located in a highly specialized microenvironment called niche that regulates their fate. Although several studies have been deve...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Costa GMJ,Sousa AL,Figueiredo AFA,Lacerda SMSN,França LR

    更新日期:2019-03-01 00:00:00

  • Some new observations on the binding of thyroxine and triiodothyronine to plasma proteins and lipoproteins in the domestic fowl.

    abstract::In addition to the previously recognised thyroid hormone-binding proteins, three plasma components possibly involved in T3 and T4 transport have been identified in chicken plasma using gel filtration at pH 7.4. In mature female, though not male and immature female birds, a significant amount of T3 (11%) is bound to ve...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Mitchell MA,Stiles MS

    更新日期:1985-02-01 00:00:00

  • Postprandial effects on appetite-related neuropeptide expression in the brain of Atlantic salmon, Salmo salar.

    abstract::Following feeding of a single meal to Atlantic salmon, the temporal changes in the brain mRNA expression of neuropeptide y (npy), cocaine-amphetamine regulated transcript (cart), peptide yy (pyy), two isoforms of agouti-related protein (agrp), two isoforms of cholecystokinin (cck), and four isoforms of proopiomelanoco...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Valen R,Jordal AE,Murashita K,Rønnestad I

    更新日期:2011-05-01 00:00:00

  • The effects of neurohypophysial hormones on the vascular resistance of the isolated perfused gill of the European eel, Anguilla anguilla L.

    abstract::Arginine vasotocin (AVT) and oxytocin (OXY), in the dose range of 2 X 10(-13)-2 X 10(-8) mol, were found to be potent vasoconstrictors of the arterioarterial pathway of isolated perfused eel gills. AVT was significantly (P less than 0.05) more potent than OXY, as indicated by the results of both dose- and concentratio...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Bennett MB,Rankin JC

    更新日期:1986-10-01 00:00:00

  • Glucocorticoid receptor upregulation during seawater adaptation in a euryhaline teleost, the tilapia (Oreochromis mossambicus).

    abstract::Cortisol is an important seawater (SW) osmoregulatory hormone in the Mozambique tilapia (Oreochromis mossambicus), a highly euryhaline cichlid able to live in environments ranging from fresh water (FW) to salinities well in excess of full-strength seawater. Previous studies indicate that cortisol may promote SW adapta...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Dean DB,Whitlow ZW,Borski RJ

    更新日期:2003-06-01 00:00:00

  • Identification and quantification of 5α-dihydrotestosterone in the teleost fathead minnow (Pimephales promelas) by gas chromatography-tandem mass spectrometry.

    abstract::The steroid hormone 5α-dihydrotestosterone (DHT) is one of the most physiologically important androgens in male vertebrates, with the exception of teleost fish, in which it is generally assumed that DHT does not play any major physiological role. However, this assumption is challenged by the fact that all the componen...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Margiotta-Casaluci L,Courant F,Antignac JP,Le Bizec B,Sumpter JP

    更新日期:2013-09-15 00:00:00

  • Ovarian development in red-sided garter snakes, Thamnophis sirtalis parietalis: relationship to mating.

    abstract::Female red-sided garter snakes (Thamnophis sirtalis parietalis) exhibit a complex array of behavioral patterns. Females may mate once, more than once, or not at all in the spring of the year, and a high percentage of females may mate in late summer before returning to winter hibernacula. The role of mating in the indu...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Whittier JM,Crews D

    更新日期:1986-01-01 00:00:00

  • Glucosidation of estradiol-17 beta in the cultured ovaries of the silkworm, Bombyx mori.

    abstract::Metabolic pathways of estradiol-17 beta and other vertebrate steroid hormones of cultured silkworm pupal ovaries were examined using 14C-labeled steroids. The isolated ovaries showed significant uptake and metabolic activity of the 14C-labeled estradiol-17 beta added to the medium. Analysis of the metabolized compound...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Ogiso M,Fujimoto Y,Ikekawa N,Ohnishi E

    更新日期:1986-03-01 00:00:00

  • Characterisation of melatonin binding sites in the eye of the Japanese quail (Coturnix japonica).

    abstract::Melatonin binding sites were examined in the quail eye using 2-[125]iodomelatonin. Radioreceptor assays indicated similar binding sites in membrane preparations of neural retina (NR) and choroid-retinal pigment epithelium (C-RPE) eye components. In both tissues binding of the radioligand was specific, saturable, and o...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: James K,Skene DJ,Lucini V,Stankov B,Arendt J

    更新日期:1995-11-01 00:00:00

  • Changes in baseline and stress-induced glucocorticoid levels during the active period in free-ranging male and female little brown myotis, Myotis lucifugus (Chiroptera: Vespertilionidae).

    abstract::Baseline and stress-responsive glucocorticoid (GC) levels were characterized during the active period in free-ranging male and reproductive female little brown myotis (Myotis lucifugus). Bats were trapped and blood was sampled within 3 min of capture at two maternity sites during the summer and at one swarming site pr...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Reeder DM,Kosteczko NS,Kunz TH,Widmaier EP

    更新日期:2004-04-01 00:00:00

  • Influence of calcitonin administration of serum calcium and inorganic phosphate level of the frog, Rana tigrina.

    abstract::The effect of salmon calcitonin (0.25 MRC mU/g body wt) was investigated on the serum calcium and inorganic phosphate levels of the frog. Rana tigrina. The hormone evokes hypocalcemia (on Day 1 and Day 3) which is followed by a significant hypercalcemia on Day 10. Thereafter, the level of calcium decreases again on Da...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Srivastav AK,Rani L

    更新日期:1989-04-01 00:00:00

  • Tetrapod-like hypothalamo-hypophysial portal system in the teleost Megalops cyprinoides (Broussonet).

    abstract::A tetrapod-like hypothalamo-hypophysial portal system and a persistent bucco-hypophysial canal are present in Megalops cyprinoides. The complicated loops of the primary capillary plexus are seen on the ventral side of the infundibular floor and contact the perikarya of the nucleus lateralis tuberis and the preoptico-h...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Baskaran G,Sathyanesan AG

    更新日期:1992-05-01 00:00:00

  • An immunohistochemical study of enteropancreatic endocrine cells in larvae and juveniles of the southern-hemisphere lampreys Geotria australis and Mordacia mordax.

    abstract::The cell types within the endocrine pancreatic tissue and anterior intestine of larvae and juveniles of representatives of the two southern-hemisphere families (Mordaciidae and Geotriidae) were compared, using immunohistochemistry and antisera against insulin (lamprey, bovine), two somatostatins (SST-14, -34), two PP-...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Youson JH,Potter IC

    更新日期:1993-11-01 00:00:00

  • Regulation of melanotropin release from the pars intermedia of the amphibian Xenopus laevis: evaluation of the involvement of serotonergic, cholinergic, or adrenergic receptor mechanisms.

    abstract::Melanophore-stimulating hormone (MSH) release from the pars intermedia of the pituitary gland is probably regulated by multiple factors of hypothalamic origin. We have examined a number of potential regulatory factors for their effects on MSH release from the amphibian Xenopus laevis. Serotonin and acetylcholine have ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Verburg-van Kemenade BM,Jenks BG,van Overbeeke AP

    更新日期:1986-09-01 00:00:00

  • Regulation of hepatic growth hormone receptors in coho salmon (Oncorhynchus kisutch).

    abstract::Factors potentially regulating hepatic growth hormone (GH) receptors in coho salmon (Oncorhynchus kisutch) have been investigated. From December to June of the first year, relative changes in hepatic 125I-sGH binding and 35SO4 incorporation by ceratobranchial cartilage were similar. Stunted salmon, which in seawater h...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Gray ES,Kelley KM,Law S,Tsai R,Young G,Bern HA

    更新日期:1992-11-01 00:00:00

  • The effects of estrogen on skeletal calcium metabolism and on plasma parameters of vitellogenesis in the male, three-toed box turtle (Terrapene carolina triunguis).

    abstract::The box turtle (Terrapene carolina triunguis) does not appear to have evolved a mechanism for secondary bone formation similar to Aves inasmuch as several parameters of bone calcium metabolism were unaffected by estrogen treatment. This suggests that reproduction does not constitute a substantial stress to the calcium...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Magliola L

    更新日期:1984-04-01 00:00:00

  • Sexual dimorphism in numbers of vasotocin-immunoreactive neurons in brain areas associated with reproductive behaviors in the roughskin newt.

    abstract::Vasotocin (VT) and vasopressin control many endocrine and neuroendocrine functions, including the regulation of reproductive behaviors. In the roughskin newt (Taricha granulosa), VT administration can enhance courtship behaviors in males and egg-laying behaviors in females. This study used immunohistochemistry to inve...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Moore FL,Richardson C,Lowry CA

    更新日期:2000-02-01 00:00:00

  • A novel thyroid stimulating hormone beta-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid.

    abstract::Thyroid stimulating hormone (TSH) is produced by the anterior pituitary and is used to regulate thyroid hormone output, which in turn controls metabolic activity. Currently, the pituitary is believed to be the only source of TSH used by the thyroid. Recent studies in mice from our laboratory have identified a TSHbeta ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Schaefer JS,Klein JR

    更新日期:2009-07-01 00:00:00

  • Effects of time, photoperiod, and pinealectomy on ocular and plasma melatonin concentrations in the chick.

    abstract::Pinealectomized and intact chicks raised under cyclic (14L:10D) and noncyclic (OL;24L) conditions of environmental lighting were sampled 60 hr and 6 weeks after pinealectomy to evaluate the effects of pineal ablation on plasma and ocular melatonin concentrations. Little or no immunoreactive melatonin was present in pl...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Osol G,Schwartz B,Foss DC

    更新日期:1985-06-01 00:00:00

  • Effect of methallibure on gestation in the guppy, Poecilia reticulata.

    abstract::Methallibure treatment (1 mg fed on alternate days to a female and a male kept in 1 liter of 25% seawater) started from 1 or 7 days postpartum (early gestation) inhibited gestation in the wild guppy, Poecilia reticulata. A few of the fish treated from 7 days postpartum (2/9) did give birth, but the young either were d...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Lam TJ,Pavri C,Ng KL

    更新日期:1985-11-01 00:00:00

  • Growth hormone and gonadotropin secretion in the common carp (Cyprinus carpio L.): in vitro interactions of gonadotropin-releasing hormone, somatostatin, and the dopamine agonist apomorphine.

    abstract::The effects of salmon gonadotropin-releasing hormone (sGnRH) and the superactive agonist [D-Arg6, Pro9NEt]-sGnRH (sGnRH-A) on growth hormone (GH) and gonadotropin (GtH) release were examined using a perifusion system for pituitary fragments of the common carp (Cyprinus carpio). Perifusion of 2-min pulses of different ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Lin XW,Lin HR,Peter RE

    更新日期:1993-01-01 00:00:00

  • Identification of testosterone and progesterone in hemolymph of larvae of the fleshfly Sarcophaga bullata.

    abstract::Testosterone- and progesterone-like substances were detected by radioimmunoassay (RIA) in chromatographed extracts of hemolymph from larvae of Sarcophaga bullata (S.B.). Gas chromatographic (GC) analysis after heptafluorobutyric acid (HFBA) derivation of hemolymph extracts, purified by paper and silica gel column chro...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: De Clerck D,Eechaute W,Leusen I,Diederik H,De Loof A

    更新日期:1983-12-01 00:00:00

  • Characterization of dopamine D2 receptors in the pituitary of the African catfish, Clarias gariepinus.

    abstract::Dopamine receptors in the pituitary of the African catfish, Clarias gariepinus, were characterized using [3H]spiperone as radioligand. Specific binding of [3H]spiperone to pituitary membranes reached equilibrium within 60 min of incubation. The binding of the radioligand was tissue specific since the amount of binding...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Van Asselt LA,Goos HJ,De Leeuw R,Peter RE,Hol EM,Wassenberg FP,Van Oordt PG

    更新日期:1990-10-01 00:00:00

  • An insulin-like growth factor found in hepatopancreas implicates carbohydrate metabolism of the blue crab Callinectes sapidus.

    abstract::Hyperglycemia that is caused by the release of crustacean hyperglycemic hormone (CHH) from the sinus gland to hemolymph is one of the hallmark physiological phenomena, occurring in decapod crustaceans experiencing stressful conditions. However, the mechanism(s) by which such elevated glucose levels return to resting l...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Chung JS

    更新日期:2014-04-01 00:00:00

  • Sex differentiation in the hagfish Eptatretus stouti.

    abstract::A detailed study was made of sex differentiation in three anteroposteriorly distributed body regions of the long gonadal fold in young Pacific hagfish (Eptatretus stouti) from 12.4 to 45 cm in length. In general, the posterior region, adjacent to the cloaca, remained undifferentiated, and only in specimens more than 2...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Gorbman A

    更新日期:1990-02-01 00:00:00

  • Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish.

    abstract::The endocannabinoid system is a major regulator of food intake in many animal species. Studies conducted so far have mostly focused on mammals, and, therefore, in this study, the role of the endocannabinoid system in food intake in the sea bream Sparus aurata was investigated. The effect of different doses of the endo...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Piccinetti CC,Migliarini B,Petrosino S,Di Marzo V,Carnevali O

    更新日期:2010-04-01 00:00:00

  • Hysteresis and calcium set-point for the calcium parathyroid hormone relationship in healthy horses.

    abstract::Abnormalities in calcium (Ca(2+)) homeostasis are reported in horses with several pathological conditions; however, there is little information on Ca(2+) regulation in horses. The objectives of the present study were to determine the Ca(2+) set-point in healthy horses, to determine whether the Ca(2+)/parathyroid hormo...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Toribio RE,Kohn CW,Sams RA,Capen CC,Rosol TJ

    更新日期:2003-02-15 00:00:00

  • Multiple limb autotomy can trigger either ovarian growth or somatic growth in the freshwater crab, Paratelphusa hydrodromous (Herbst).

    abstract::In female Paratelphusa, there appear to be two alternating dominant physiological tendencies, one biased in favor of reproductive (ovarian) growth and another biased in favor of somatic (regenerative) growth. Multiple limb autotomy (MA), long known to stimulate somatic growth, did so only if the crab was physiological...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Kurup KN,Adiyodi RG

    更新日期:1984-12-01 00:00:00

  • Dynorphin modulates prolactin secretion in the turkey.

    abstract::Big dynorphin (prodynorphin 209-240), dynorphin A (prodynorphin 209-225), dynorphin B (prodynorphin 228-240), beta-endorphin (beta-lipotrophin 61-90), or Met-enkephalin, each infused into the third ventricle, were tested for their effect on PRL release in the anesthetized turkey hen. Laying hens that received big dyno...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Youngren OM,Silsby JL,Phillips RE,el Halawani ME

    更新日期:1993-08-01 00:00:00