Abstract:
:Replication-deficient adenoviral vectors are promising agents for human gene therapy of the greater transduction efficiency than other vectors. However, there are distinct disadvantages, including high immunogenicity, which limits the administration to human organs, particularly the brain. Injection of adenoviral vectors into the human brain causes inflammatory responses and induces cerebral edema. The combined effect of adenoviral vectors and cationic liposomes in vitro was investigated in an effort to reduce the immune reaction against the antigens of adenoviral vectors. No toxicity of adenoviral vector-associated liposomes was observed within optimal lipid concentration. The transduction efficiency of the adenoviral vectors containing the beta-galactosidase gene increased almost 10-fold when associated with the cationic liposomes. Furthermore, greater cytotoxicity was induced when the adenoviral vector containing herpes simplex virus-thymidine kinase gene was combined with cationic liposomes than with only the adenoviral vector. These results suggest that the combination of adenoviral vectors and cationic liposomes allows the doses of adenoviral vectors to be reduced while maintaining transduction efficiency.
journal_name
Neurol Med Chir (Tokyo)journal_title
Neurologia medico-chirurgicaauthors
Ryuke Y,Mizuno M,Natsume A,Yoshida Jdoi
10.2176/nmc.40.256keywords:
subject
Has Abstractpub_date
2000-05-01 00:00:00pages
256-60issue
5eissn
0470-8105issn
1349-8029pii
JST.JSTAGE/nmc/40.256journal_volume
40pub_type
杂志文章abstract::Changes in the mean cerebral blood flow (mCBF) with growth in normal children (1-20 years old) were evaluated, and compared to serial mCBF changes in children with spontaneous occlusion of the circle of Willis (moyamoya disease) after vascular reconstructive surgery. mCBF gradually decreased with growth in control chi...
journal_title:Neurologia medico-chirurgica
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abstract::Hemorrhage in regions remote from the site of initial intracranial operations is rare, but may be fatal. Postoperative cerebellar hemorrhage as a complication of supratentorial surgery, with a radiological appearance known as zebra sign, is an increasingly recognized clinical entity and is associated mainly with vascu...
journal_title:Neurologia medico-chirurgica
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journal_title:Neurologia medico-chirurgica
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journal_title:Neurologia medico-chirurgica
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abstract::A 48-year-old female was stabbed by her husband with a chopstick made of wood in the left temporal region during a quarrel. She suffered laceration of the left temporal scalp. At initial examination, she concealed the assault with a chopstick. Radiography showed no abnormality, so the wound was sutured. One month afte...
journal_title:Neurologia medico-chirurgica
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doi:10.2176/nmc.39.744
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abstract::A 27-year-old male presented with a rare association of a ruptured orbitofrontal artery aneurysm and a dural arteriovenous malformation (DAVM) fed by both ethmoidal arteries, manifestation as severe headache, nausea, and vomiting. Computed tomography revealed a hematoma within the right frontal lobe and diffuse subara...
journal_title:Neurologia medico-chirurgica
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doi:10.2176/nmc.39.157
更新日期:1999-02-01 00:00:00
abstract::Bevacizumab has been reported to be effective for recurrent glioblastoma. In our hospital, ifosfamide, carboplatin, etoposide (ICE) is the second-line chemotherapy for first recurrence of glioblastoma after temozolomide failure. In the present analysis, we retrospectively investigated the feasibility and effectiveness...
journal_title:Neurologia medico-chirurgica
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journal_title:Neurologia medico-chirurgica
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journal_title:Neurologia medico-chirurgica
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journal_title:Neurologia medico-chirurgica
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journal_title:Neurologia medico-chirurgica
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更新日期:2001-05-01 00:00:00
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journal_title:Neurologia medico-chirurgica
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doi:10.2176/nmc.29.20
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journal_title:Neurologia medico-chirurgica
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doi:10.2176/nmc.29.88
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journal_title:Neurologia medico-chirurgica
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journal_title:Neurologia medico-chirurgica
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journal_title:Neurologia medico-chirurgica
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journal_title:Neurologia medico-chirurgica
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journal_title:Neurologia medico-chirurgica
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journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
abstract::After introduction of levetiracetam (LEV), treatment of seizures in patients with malignant brain tumors has prominently improved. On the other hand, we still experience some cases with LEV-uncontrollable epilepsy. Perampanel (PER) is a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoaxazolepropionate acid receptor ant...
journal_title:Neurologia medico-chirurgica
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journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
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abstract::A 5-month-old boy presented with a rare case of intramedullary teratoma extending from T1 to S5 and associated with a lumbosacral lipoma. Magnetic resonance imaging showed the tumor extended over the lipoma. Since the tumor could not be clearly demarcated from the spinal cord, surgery was performed under a preoperativ...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.51.393
更新日期:2011-01-01 00:00:00
abstract::A 62-year-old male presented with a rare intraosseous meningioma with intradural extension manifesting as frequent vomiting and floating sensation that had persisted for 3 months. Neuroimaging detected a mass lesion that was mainly located extradurally in the right posterior fossa with a daughter lesion inside the dur...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章,评审
doi:10.2176/nmc.41.149
更新日期:2001-03-01 00:00:00