Angiotensin-converting enzyme inhibitor cilazapril suppresses expression of basic fibroblast growth factor messenger ribonucleic acid and protein in endothelial and intimal smooth muscle cells in a vascular injury model of spontaneous hypertensive rats.

Abstract:

:The relationship between the expression of basic fibroblast growth factor (bFGF) messenger ribonucleic acid (mRNA) and protein, a potent mitogen for vascular smooth muscle cells in vivo, and administration of the angiotensin-converting enzyme inhibitor cilazapril, which suppresses smooth muscle cells proliferation in denuded arteries, was studied in spontaneously hypertensive rats using the in situ hybridization technique and immunohistochemical study. The effect of cilazapril on neointimal formation through modification of bFGF expression was evaluated using the increased tissue expression of the renin-angiotensin system in spontaneously hypertensive rats. Arterial injury was produced by using balloon catheter denudation in the left carotid artery of rats. The effects were evaluated 2 weeks later. bFGF mRNA and protein were observed only in the endothelial cells of sham-operated rats. bFGF mRNA and protein were observed in both endothelial cells and intimal smooth muscle cells in operated rats receiving only vehicle. Expression of bFGF mRNA and protein was suppressed in both endothelial cells and intimal smooth muscle cells of operated rats receiving cilazapril. These data suggest that cilazapril suppresses smooth muscle cell proliferation through modification of the expression of bFGF mRNA and bFGF protein in addition to other genes.

authors

Iwata A,Masago A,Yamada K

doi

10.2176/nmc.38.257

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

257-64; discussion 264-5

issue

5

eissn

0470-8105

issn

1349-8029

pii

JST.Journalarchive/nmc1959/38.257

journal_volume

38

pub_type

杂志文章
  • Meningeal hemangiopericytoma manifesting as massive intracranial hemorrhage--two case reports.

    abstract::Meningeal hemangiopericytoma is rare, and only seven cases have manifested as intracranial hemorrhage. We treated two patients with meningeal hemangiopericytoma manifesting as life-threatening massive intracerebral hemorrhage. Case 1: A 66-year-old woman presented with consciousness disturbance and left hemiparesis. C...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.46.92

    authors: Maruya J,Seki Y,Morita K,Nishimaki K,Minakawa T

    更新日期:2006-02-01 00:00:00

  • Remote cerebellar hemorrhage (zebra sign) in vascular neurosurgery: pathophysiological insights.

    abstract::Hemorrhage in regions remote from the site of initial intracranial operations is rare, but may be fatal. Postoperative cerebellar hemorrhage as a complication of supratentorial surgery, with a radiological appearance known as zebra sign, is an increasingly recognized clinical entity and is associated mainly with vascu...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.49.229

    authors: Figueiredo EG,de Amorim RL,Teixeira MJ

    更新日期:2009-06-01 00:00:00

  • Management of Spontaneous Intracerebral Hematoma.

    abstract::The incidence of spontaneous intracerebral hematoma (SICH) is even now high worldwide, especially higher in Japan than in Western countries, despite the development of advances in blood pressure (BP) management and food/alcohol intake education. Although mortality and morbidity for SICH are high, some controversies re...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.ra.2016-0327

    authors: Morioka M,Orito K

    更新日期:2017-11-15 00:00:00

  • Limited efficacy of endoscopic third ventriculostomy for hydrocephalus following aneurysmal subarachnoid hemorrhage.

    abstract::Endoscopic third ventriculostomy (ETV) has not been recognized as a surgical option for hydrocephalus following aneurysmal subarachnoid hemorrhage (SAH), since hydrocephalus following aneurysmal SAH is considered to result from the communicating component. However, obstructions in the ventricular system may exist, so ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.49.449

    authors: Fukuhara T,Shimizu T,Namba Y

    更新日期:2009-10-01 00:00:00

  • Acute subdural hematoma after intra-arterial thrombolysis for acute ischemic stroke--case report.

    abstract::A 79-year-old man with a cardiac pacemaker for bradycardia fell down and presented with sudden onset of right hemiplegia and aphasia. Initial computed tomography (CT) showed no cerebral infarction but angiography revealed occlusion of the left middle cerebral artery (MCA). Local intra-arterial thrombolysis with tissue...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.45.627

    authors: Meguro T,Higashi H,Nishimoto K

    更新日期:2005-12-01 00:00:00

  • Removal of petrous apex meningioma and microvascular decompression for trigeminal neuralgia through the anterior petrosal approach. Case report.

    abstract::A 64-year-old female presented with right trigeminal neuralgia. Computed tomography and magnetic resonance (MR) imaging demonstrated a tumor attached to the right petrous apex. MR imaging also revealed that the trigeminal nerve was compressed and distorted by the tumor. Tumor removal and microvascular decompression (M...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.39.447

    authors: Kuroki A,Kayama T,Song J,Saito S

    更新日期:1999-06-01 00:00:00

  • Coil embolization of a ruptured aneurysm arising from a middle cerebral artery fenestration--case report.

    abstract::An 81-year-old woman was transferred to our hospital after suffering loss of consciousness. Computed tomography revealed subarachnoid hemorrhage. Angiography revealed middle cerebral artery fenestration and a ruptured aneurysm arising from the inferior limb of the fenestrated artery. Coil embolization of the aneurysm ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.50.213

    authors: Yamaguchi S,Ito O,Suzuki S

    更新日期:2010-01-01 00:00:00

  • Spontaneous slow drainage of epidural hematoma into the subgaleal space through a skull fracture in an infant--case report.

    abstract::A 4-month-old girl fell off a table onto the floor. Computed tomography performed 4 hours after the trauma showed a left parietal epidural hematoma (EDH) with an omega-shaped fracture line in the left parietal region. The EDH was enlarged after another 4 hours. However, the EDH showed drainage into the subgaleal space...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.51.854

    authors: Chida K,Yukawa H,Mase T,Endo H,Ogasawara K

    更新日期:2011-01-01 00:00:00

  • Morphological effects of tumor necrosis factor-alpha on the blood vessels in rat experimental brain tumors.

    abstract::The morphological changes in the vascular endothelium caused by the administration of tumor necrosis factor-alpha (TNF-alpha) were studied in an experimental model of rat brain tumors. Wistar rats bearing implanted C6 glioma received human natural-type TNF-alpha (1.7 x 10(5) U/m2) through the carotid artery and were s...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.36.423

    authors: Isaka T,Yoshimine T,Maruno M,Hayakawa T

    更新日期:1996-07-01 00:00:00

  • A biomechanical comparison of three different posterior fixation constructs used for c6-c7 cervical spine immobilization: a finite element study.

    abstract::The intralaminar screw construct has been recently introduced in C6-C7 fixation. The aim of the study is to compare the stability afforded by three different C7 posterior fixation techniques using a three-dimensional finite element model of a C6-C7 cervical spine motion segment. Finite element models representing thre...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.oa.2013-0004

    authors: Hong JT,Qasim M,Espinoza Orías AA,Natarajan RN,An HS

    更新日期:2014-01-01 00:00:00

  • Effects of irradiation on the expression of the adhesion molecules (NCAM, ICAM-1) by glioma cell lines.

    abstract::The expression of the intercellular adhesion molecule-1 (ICAM-1) and neural cell adhesion molecule (NCAM) by glioma cell lines was investigated. The effects of interferon (IFN)-gamma or irradiation on the expression was also assessed. Two glioma cell lines showed more than 75% NCAM-positive cells. After treatment with...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.33.749

    authors: Yamanaka R,Tanaka R,Yoshida S

    更新日期:1993-11-01 00:00:00

  • Epidermoid cyst in Meckel's cave with unusual computed tomography and magnetic resonance imaging findings. Case report.

    abstract::A 27-year-old woman presented with headache and occasional numbness over her right face. Computed tomography revealed a hypodense mass in the middle cranial fossa and another adjacent hyperdense mass in the posterior fossa with erosion of the right petrous apex. Magnetic resonance imaging revealed the lesion in the mi...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.50.701

    authors: Arai A,Sasayama T,Koyama J,Fujita A,Hosoda K,Kohmura E

    更新日期:2010-01-01 00:00:00

  • Simulation of clipping position for cerebral aneurysms using three-dimensional computed tomography angiography.

    abstract::A novel method for the simulation of the clipping position for cerebral aneurysms based on three-dimensional computed tomography (3D CT) angiography was evaluated. Rotating the regional 3D CT angiography images including the aneurysm provided the virtual intraoperative views of 36 cerebral aneurysms that were eligible...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.44.6

    authors: Futami K,Nakada M,Iwato M,Kita D,Miyamori T,Yamashita J

    更新日期:2004-01-01 00:00:00

  • Simple new method for making a rat carotid artery post-angioplasty stenosis model.

    abstract::A simple new method for making a rat post-angioplasty stenosis model was developed using a single-lumen compliant balloon catheter/guidewire system and no special diet. This technique was applied to 10 9-week-old Wistar rats fed a normal diet. The catheter/guidewire system was inserted from the external carotid artery...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.47.525

    authors: Tsuruta W,Yamamoto T,Suzuki K,Yoshida F,Matsumura A

    更新日期:2007-11-01 00:00:00

  • Hearing Restoration with Auditory Brainstem Implant.

    abstract::Auditory brainstem implant (ABI) technology attempts to restore hearing in deaf patients caused by bilateral cochlear nerve injury through the direct stimulation of the brainstem, but many aspects of the related mechanisms remain unknown. The unresolved issues can be grouped into three topics: which patients are the b...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.ra.2016-0080

    authors: Nakatomi H,Miyawaki S,Kin T,Saito N

    更新日期:2016-10-15 00:00:00

  • Medulloblastoma associated with cysts and calcifications--case report.

    abstract::An 11-year-old boy presented with medulloblastoma occurring in the cerebellar vermis. Computed tomography and magnetic resonance imaging revealed numerous cysts and calcifications in the tumor. The tumor was subtotally removed and cellular synchronization radiation therapy given. He was discharged without neurological...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.34.375

    authors: Tsunoda S,Kurokawa S,Sakaki T,Yabuno T,Tsuzuki T,Kawaguchi S,Kiriishi R,Morimoto T

    更新日期:1994-06-01 00:00:00

  • High-velocity gunshot wounds to the head: analysis of 135 patients.

    abstract::Head injuries due to high-velocity missiles and shrapnel as a result of military conflicts have become a very important cause of death or severe neurological deficits. Military-type missiles have high velocities and transfer higher amounts of energy to neural tissue, compared to civil-type missiles. This physical phen...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.45.281

    authors: Bakir A,Temiz C,Umur S,Aydin V,Torun F

    更新日期:2005-06-01 00:00:00

  • Novel intraoperative cerebral blood flow monitoring by laser-Doppler scanner.

    abstract::Laser-Doppler (LD) flowmetry was used to measure tissue perfusion non-invasively and continuously during neurosurgical operations using an LD scanner. Scanning was usually completed in 20 seconds. Measurements were processed in software to provide a color-coded image of the tissue perfusion. Moreover, the measurement ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.42.1

    authors: Nakase H,Kaido T,Okuno S,Hoshida T,Sakaki T

    更新日期:2002-01-01 00:00:00

  • Symptomatic hemorrhage associated with recurrent pilocytic astrocytoma with granulation tissue--case report.

    abstract::A 51-year-old woman had been followed up for 10 years for recurrence of pilocytic astrocytoma 5 years after the initial treatment consisting of subtotal resection, chemotherapy, and radiation therapy. The patient presented with sudden onset of headache and vomiting. Computed tomography and T(2)*-weighted magnetic reso...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.47.222

    authors: Shingu T,Akiyama Y,Daisu M,Maruyama N,Matsumoto Y,Miyazaki T,Nagai H,Yamamoto Y,Yamasaki T,Yoshida M,Maruyama R,Moritake K

    更新日期:2007-05-01 00:00:00

  • Potential risk of artificial cerebrospinal fluid solution without magnesium ion for cerebral irrigation and perfusion in neurosurgical practice.

    abstract::The effect of irrigation with artificial cerebrospinal fluid (CSF) containing various magnesium ion (Mg(2+)) concentrations on vasospastic arteries was investigated in the dog. Cerebral vasospasm was induced by the experimental subarachnoid hemorrhage model in 15 beagle dogs. Cisternal irrigation was performed for 1 h...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.oa2012-0295

    authors: Mori K,Yamamoto T,Miyazaki M,Hara Y,Koike N,Nakao Y

    更新日期:2013-01-01 00:00:00

  • Basilar invagination associated with an intercarotid paraganglioma--case report.

    abstract::A 24-year-old female presented with basilar invagination and kyphoscoliosis of the cervical spine associated with a large intercarotid paraganglioma. She had suffered from pharyngeal discomfort from the age of 9 years due to the tumor. The tumor had originated from the right carotid body and extended in the parapharyn...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.37.279

    authors: Ishii N,Sawamura Y,Tada M,Kato T,Abe H

    更新日期:1997-03-01 00:00:00

  • Growth hormone-producing pituitary adenomas: MR characteristics and pre- and postoperative evaluation.

    abstract::Twelve patients with growth hormone-producing pituitary adenomas were investigated to evaluate correlations between magnetic resonance (MR) appearance and tissue characteristics, sellar expansion, suprasellar tumor extension, and tumor consistency. MR imaging could detect microadenomas with a characteristic enhancemen...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.33.81

    authors: Chakrabortty S,Oi S,Yamaguchi M,Tamaki N,Matsumoto S

    更新日期:1993-02-01 00:00:00

  • Cilostazol reduces periprocedural hemodynamic depression in carotid artery stenting.

    abstract::The clinical effects of two different types of antiplatelet drugs, cilostazol and thienopyridine drugs, were compared in patients treated by carotid artery stenting (CAS). Two hundred patients scheduled for CAS were randomized to either cilostazol or a thienopyridine drug (ticlopidine or clopidogrel). The study was co...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,随机对照试验

    doi:10.2176/nmc.53.163

    authors: Tsutsumi M,Aikawa H,Nii K,Etou H,Sakamoto K,Kureshima M,Inoue R,Yoshida H,Matsumoto Y,Narita S,Kazekawa K

    更新日期:2013-01-01 00:00:00

  • Effects of naloxone on prolactin-secreting pituitary adenomas.

    abstract::The investigators assessed the effects of the opioid antagonist naloxone on anterior pituitary hormone release in hyperprolactinemic females with pituitary microadenoma (n = 6) and macroadenoma (n = 7). In those with microadenoma, intravenous bolus injection of naloxone significantly increased serum luteinizing hormon...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.30.109

    authors: Shima K,Chigasaki H,Seki K

    更新日期:1990-02-01 00:00:00

  • Time course of expression of three nitric oxide synthase isoforms after transient middle cerebral artery occlusion in rats.

    abstract::The involvement of nitric oxide synthase (NOS) in ischemia was evaluated by detecting the expression of neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS) by the immunohistochemical method in the rat model of middle cerebral artery (MCA) occlusion. Transient MCA occlusion (2 hours) was induced in 32...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.41.63

    authors: Niwa M,Inao S,Takayasu M,Kawai T,Kajita Y,Nihashi T,Kabeya R,Sugimoto T,Yoshida J

    更新日期:2001-02-01 00:00:00

  • Internal carotid artery obstruction derived from persistent arterial wall dissection associated with old trivial trauma.

    abstract::A 59-year-old man presented with acute onset of visual loss in his right eye. He was treated under a diagnosis of retinal artery thrombosis. Ultrasonography revealed obstruction of the ipsilateral internal carotid artery (ICA). He had no risk factor for stroke and he denied any history of trauma. Follow-up ultrasonogr...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.46.395

    authors: Akiyama Y,Tanaka M,Hayashi J,Fujimoto M,Harada K,Nakahara I,Taniwaki Y

    更新日期:2006-08-01 00:00:00

  • Cerebral ischemia promotes rich pseudopalisading necrosis in the rat c6 glioblastoma model.

    abstract::The effect of hypoxia on glioma growth including pathological changes was investigated in an experimental model of brain ischemia in the rat C6 glioma model. C6 glioma cells were inoculated into the subcortex of adult Wistar rats. Focal cerebral ischemia near the implanted glioma area was induced by permanent middle c...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.49.294

    authors: Mamun MH,Kamitani H,Kinoshita Y,Tabuchi S,Wasita B,Watanabe T

    更新日期:2009-07-01 00:00:00

  • [Single burr hole irrigation without drainage in chronic subdural hematoma].

    abstract::The surgical treatment of chronic subdural hematoma has evolved from membranectomy through craniotomy to burr hole irrigation. The latter approach is based on utilization of the natural absorptive process that is thought to be part of the life cycle of the hematoma. To test this theory, the authors treated fifty-nine ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.29.117

    authors: Iwadate Y,Ishige N,Hosoi Y

    更新日期:1989-02-01 00:00:00

  • Fluorine-18-fluorodeoxyglucose positron emission tomography may predict the outcome in patients with asymptomatic mild stenosis of internal carotid artery--case report.

    abstract::A 47-year-old male presented with asymptomatic mild (45%) internal carotid artery (ICA) stenosis associated with familial hypercholesterolemia. Fluorine-18-fluorodeoxyglucose ([(18)F]FDG) positron emission tomography (PET) showed that the carotid plaque had high uptake of [(18)F]FDG on the initial scan. He was treated...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.51.720

    authors: Motegi H,Kuroda S,Nakayama N,Hirata K,Shiga T,Tamaki N

    更新日期:2011-01-01 00:00:00

  • Pituitary abscess showing high uptake of thallium-201 on single photon emission computed tomography--case report.

    abstract::A 32-year-old female presented with a rare case of pituitary abscess manifesting as homonymous hemianopsia. Serum prolactin level was slightly high (40.8 ng/ml). Magnetic resonance (MR) imaging showed the content of the lesion as homogeneously isointense on the T1-weighted images and hyperintense on the T2-weighted im...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.43.100

    authors: Shimamura N,Ogane K,Takahashi T,Tabata H,Ohkuma H,Suzuki S

    更新日期:2003-02-01 00:00:00