Estimating survival gain for economic evaluations with survival time as principal endpoint: a cost-effectiveness analysis of adding early hormonal therapy to radiotherapy in patients with locally advanced prostate cancer.

Abstract:

:The problem of estimating expected outcomes for the economic evaluation of treatments for which the outcome of principal interest is (quality adjusted) survival time has so far not received sufficient attention in the literature. The best estimate of expected survival is mean survival time, but with censored survival data, the true survival time for all the subjects is not known, so the mean is not defined.A possible solution to this estimation problem is illustrated by a retrospective cost-effectiveness analysis of the addition of hormonal therapy to standard radiotherapy for patients with locally advanced prostate cancer. A recently proposed method is used to approach the problem caused by censored cost data, and the impact of uncertainty is assessed by bootstrap resampling techniques. Mean survival time is estimated by a restricted means analysis with the time point of restriction determined by statistical criteria. When average total costs and mean survival time is evaluated at this time point of restriction, the result is that the combined therapy (radiotherapy plus hormonal therapy) increases mean survival time by about 1 year, while reducing the costs per patient for the French health insurance system by 12 700 FF. The time point of restriction may also be determined by other criteria and mean survival time may be estimated by extrapolating the survival curves by means of various parametric survival distributions. We show that the exact results of the economic evaluation are decisively determined by the restriction time point chosen and the approach taken to estimate mean survival time.

journal_name

Health Econ

journal_title

Health economics

authors

Neymark N,Adriaenssen I,Gorlia T,Caleo S,Bolla M

doi

10.1002/hec.662

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

233-48

issue

3

eissn

1057-9230

issn

1099-1050

pii

10.1002/hec.662

journal_volume

11

pub_type

临床试验,杂志文章,随机对照试验
  • Measuring the effects of work loss on productivity with team production.

    abstract::Using data from a survey of 800 managers in 12 industries, we find empirical support for the hypothesis that the cost associated with missed work varies across jobs according to the ease with which a manager can find a perfect replacement for the absent worker, the extent to which the worker functions as part of a tea...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.1052

    authors: Nicholson S,Pauly MV,Polsky D,Sharda C,Szrek H,Berger ML

    更新日期:2006-02-01 00:00:00

  • Accuracy of patient recall for self-reported doctor visits: Is shorter recall better?

    abstract::In health economics, the use of patient recall of health care utilisation information is common, including in national health surveys. However, the types and magnitude of measurement error that relate to different recall periods are not well understood. This study assessed the accuracy of recalled doctor visits over 2...

    journal_title:Health economics

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/hec.3794

    authors: Dalziel K,Li J,Scott A,Clarke P

    更新日期:2018-11-01 00:00:00

  • The effect of hospital-physician integration on health information technology adoption.

    abstract::The US federal government has recently made a substantial investment to enhance the US health information technology (IT) infrastructure. Previous literature on the impact of IT on firm performance across multiple industries has emphasized the importance of a process of co-invention whereby organizations develop compl...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.2878

    authors: Lammers E

    更新日期:2013-10-01 00:00:00

  • Language Barriers and Immigrant Health.

    abstract::We study the impact of language deficiency on the health status of childhood migrants to Australia. Our identification strategy relies on a quasi-experiment comparing immigrants arriving at different ages and from different linguistic origins. In the presence of considerable non-classical measurement error in self-rep...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.3358

    authors: Clarke A,Isphording IE

    更新日期:2017-06-01 00:00:00

  • The geography of hospital admission in a national health service with patient choice.

    abstract::Each year about 20% of the 10 million hospital inpatients in Italy get admitted to hospitals outside the Local Health Authority of residence. In this paper we carefully explore this phenomenon and estimate gravity equations for 'trade' in hospital care using a Poisson pseudo-maximum likelihood method. Consistency of t...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.1639

    authors: Fabbri D,Robone S

    更新日期:2010-09-01 00:00:00

  • Household characteristics affecting where mothers deliver in rural Kenya.

    abstract::Data from a household survey were used to analyse the distribution of newborn deliveries in a rural area of Kenya. It was found that 52% of deliveries occurred at home or with traditional birth attendants. Using regression techniques, the most significant predictors of choosing an informal delivery setting are the hou...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-1050(199607)5:4<333::AID-HEC202

    authors: Hodgkin D

    更新日期:1996-07-01 00:00:00

  • Are health shocks different? Evidence from a multishock survey in Laos.

    abstract::Using primary data from Laos, we compare a broad range of different types of shocks in terms of their incidence, distribution between the poor and the better off, idiosyncrasy, costs, coping responses, and self-reported impacts on well-being. Health shocks are more common than most other shocks, more concentrated amon...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.2944

    authors: Wagstaff A,Lindelow M

    更新日期:2014-06-01 00:00:00

  • Colorectal cancer screening: efficiency and effectiveness.

    abstract::The cost-effectiveness of a series of mutually exclusive colorectal cancer screening programmes with varying screening interval and target group are analysed. Costs and effects for 60 possible screening programmes are simulated on the basis of data collected from a randomized trial initiated in 1985 in Funen County, D...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-1050(199802)7:1<9::aid-hec304>3

    authors: Gyrd-Hansen D,Søgaard J,Kronborg O

    更新日期:1998-02-01 00:00:00

  • Modelling the monetary value of a QALY: a new approach based on UK data.

    abstract::Debate about the monetary value of a quality-adjusted life year (QALY) has existed in the health economics literature for some time. More recently, concern about such a value has arisen in UK health policy. This paper reports on an attempt to 'model' a willingness-to-pay-based value of a QALY from the existing value o...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.1416

    authors: Mason H,Jones-Lee M,Donaldson C

    更新日期:2009-08-01 00:00:00

  • The role of the staff MFF in distributing NHS funding: taking account of differences in local labour market conditions.

    abstract::The National Health Service (NHS) in England distributes substantial funds to health-care providers in different geographical areas to pay for the health care required by the populations they serve. The formulae that determine this distribution reflect populations' health needs and local differences in the prices of i...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.1489

    authors: Elliott R,Ma A,Sutton M,Skatun D,Rice N,Morris S,McConnachie A

    更新日期:2010-05-01 00:00:00

  • Cost-benefit analysis of a national screening programme for cystic fibrosis in an Israeli population.

    abstract::The recently acquired ability to identify 97% of CF carriers in an Israeli Ashkenazi population, prompts an evaluation of a nationwide screening programme. In 1993, the programme would first screen and counsel 9,261 parents, then 396 spouses of carrier parents and finally screen 16.5 fetuses where both parents are car...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.4730030104

    authors: Ginsberg G,Blau H,Kerem E,Springer C,Kerem BS,Akstein E,Greenberg A,Kolumbos A,Abeliovich D,Gazit E

    更新日期:1994-01-01 00:00:00

  • Ratio-based and net benefit-based approaches to health care resource allocation: proofs of optimality and equivalence.

    abstract::Both incremental cost-effectiveness ratios and net benefits have been proposed as summary measures for use in cost-effectiveness analyses. We present a unifying proof of the optimality and equivalence of ICER- and net benefit-based approaches to the health resource allocation problem, including both 'fixed budget' and...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-1050(199903)8:2<171::aid-hec424

    authors: Laska EM,Meisner M,Siegel C,Stinnett AA

    更新日期:1999-03-01 00:00:00

  • The relationship between road traffic accidents and real economic activity in Spain: common cycles and health issues.

    abstract::This paper analyses the aggregate relationships between traffic accidents and real economic activity in Spain during the last 30 years. Our general approach is based on two basic assumptions: (1) the number of accidents depends on the use of cars and other exogenous variables, and (2) the level of economic activity af...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.1186

    authors: García-Ferrer A,De Juan A,Poncela P

    更新日期:2007-06-01 00:00:00

  • Impact of social accountability monitoring on health facility performance: Evidence from Tanzania.

    abstract::Social accountability programs are increasingly used to improve the performance of public service providers in low-income settings. Despite their growing popularity, evidence on the effectiveness of social accountability programs remains mixed. In this manuscript, we assess the impact of a social accountability interv...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.4219

    authors: Francetic I,Fink G,Tediosi F

    更新日期:2021-01-17 00:00:00

  • What is the relationship between income inequality and health? Evidence from the BHPS.

    abstract::Income inequality hypotheses propose that income differentials and/or income distributions have a detrimental effect on health. This previously well accepted relationship between inequality and health has recently come under scrutiny; some claim that it is a statistical artefact, arguing that aggregate level data are ...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.1254

    authors: Lorgelly PK,Lindley J

    更新日期:2008-02-01 00:00:00

  • Constraints on Formulary Design Under the Affordable Care Act.

    abstract::I study the effect of prescription drug essential health benefits (EHB) requirements from the Affordable Care Act on prescription drug formularies of health insurance marketplace plans. The EHB regulates the number of drugs covered but leaves other dimensions (cost sharing and utilization management) of the formulary ...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.3491

    authors: Andersen M

    更新日期:2017-12-01 00:00:00

  • The effect of national health insurance on mortality and the SES-health gradient: evidence from the elderly in Taiwan.

    abstract::Using the difference-in-difference-in-differences method, we examine the effect of the National Health Insurance (NHI) on mortality, self-assessed health, and functional limitations of the elderly and seek to determine whether the effect is spread equally across health classes. We find that the NHI only has an effect ...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.1815

    authors: Keng SH,Sheu SJ

    更新日期:2013-01-01 00:00:00

  • The role of time preferences in the intergenerational transfer of smoking.

    abstract::Evidence suggests that maternal and offspring smoking behaviour is correlated. Little is known about the mechanisms through which this intergenerational transfer occurs. This paper explores the role of time preferences. Although time preference is likely to be heritable and correlated with health investments, its role...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.2987

    authors: Brown H,van der Pol M

    更新日期:2014-12-01 00:00:00

  • Health effects of reduced workload for older employees.

    abstract::To keep elder employees in the labour force, introducing age-dependent job conditions can be a policy measure. However, we know little about the effect of such initiatives. We investigate the effects of a particular programme in Norway that reduces the workload of teachers at age 55 but maintains the same wage. Evalua...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.4002

    authors: Bratberg E,Holmås TH,Monstad K

    更新日期:2020-05-01 00:00:00

  • Adolescent depression: diagnosis, treatment, and educational attainment.

    abstract::In this paper, I use nationally representative longitudinal data to examine adolescent depression and educational attainment. First, I examine the individual, family, and community-level determinants of adolescent depression, diagnosis, and treatment. I find that male and minority adolescents who score high on depress...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.1319

    authors: Fletcher JM

    更新日期:2008-11-01 00:00:00

  • Health care policy evaluation using longitudinal insurance claims data: an application of the panel Tobit estimator.

    abstract::The British Columbia Ministry of Health provides enhanced prescription drug insurance coverage to residents aged 65 and older. This exogenous change in the effective price of prescription drugs is used to investigate aspects of the drug use by seniors. Three sets of issues are of interest. First, what is the effect of...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-1050(199707)6:4<365::aid-hec279

    authors: Grootendorst PV

    更新日期:1997-07-01 00:00:00

  • The effect of a major cigarette price change on smoking behavior in california: a zero-inflated negative binomial model.

    abstract::The objective of this paper is to determine the price sensitivity of smokers in their consumption of cigarettes, using evidence from a major increase in California cigarette prices due to Proposition 10 and the Tobacco Settlement. The study sample consists of individual survey data from Behavioral Risk Factor Survey (...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.849

    authors: Sheu ML,Hu TW,Keeler TE,Ong M,Sung HY

    更新日期:2004-08-01 00:00:00

  • Does global drug innovation correspond to burden of disease? The neglected diseases in developed and developing countries.

    abstract::Although it is commonly argued that there is a mismatch between drug innovation and disease burden, there is little evidence on the magnitude and direction of such disparities. In this paper, we measure inequality in innovation, by comparing research and development activity with population health and gross domestic p...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.3833

    authors: Barrenho E,Miraldo M,Smith PC

    更新日期:2019-01-01 00:00:00

  • Information and sorting in the market for obstetrical services.

    abstract::Using a statistical model and a partial equilibrium economic search model, we develop a methodology for appraising the value of consumer information about the quality of health care providers and apply it to information about physicians' predispositions to perform cesarean section deliveries. There are three primary r...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.968

    authors: Grant D

    更新日期:2005-07-01 00:00:00

  • The Welfare Cost of Homicides in Brazil: Accounting for Heterogeneity in the Willingness to Pay for Mortality Reductions.

    abstract::This paper estimates the health dimension of the welfare cost of homicides in Brazil incorporating age, gender, educational, and regional heterogeneities. We use a marginal willingness to pay approach to assign monetary values to the welfare cost of increased mortality due to violence. Results indicate that the presen...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.3137

    authors: Cerqueira D,Soares RR

    更新日期:2016-03-01 00:00:00

  • Childhood Obesity and Cognitive Achievement.

    abstract::Obese children tend to perform worse academically than normal-weight children. If poor cognitive achievement is truly a consequence of childhood obesity, this relationship has significant policy implications. Therefore, an important question is to what extent can this correlation be explained by other factors that joi...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.3211

    authors: Black N,Johnston DW,Peeters A

    更新日期:2015-09-01 00:00:00

  • Cost and technical efficiency of German hospitals: does ownership matter?

    abstract::This paper is the first to investigate both the technical and cost efficiency of more than 1500 German general hospitals. More specifically, it deals with the question how hospital efficiency varies with ownership, patient structure, and other exogenous factors, which are neither inputs to nor outputs of the productio...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.1388

    authors: Herr A

    更新日期:2008-09-01 00:00:00

  • Outcomes in Economic Evaluations of Public Health Interventions in Low- and Middle-Income Countries: Health, Capabilities and Subjective Wellbeing.

    abstract::Public health programmes tend to be complex and may combine social strategies with aspects of empowerment, capacity building and knowledge across sectors. The nature of the programmes means that some effects are likely to occur outside the healthcare sector; this breadth impacts on the choice of health and non-health ...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.3302

    authors: Greco G,Lorgelly P,Yamabhai I

    更新日期:2016-02-01 00:00:00

  • Equitable access to health care: methodological extensions to the analysis of physician utilization in Canada.

    abstract::In this paper we analyse the distribution of family physician use in Canada to explore whether the stated goal of reasonable access to care has been achieved. We test hypotheses to see whether (a) variations in incidence and quantity of use are independent of need for care as proxied by self-assessed health status and...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.4730020203

    authors: Birch S,Eyles J,Newbold KB

    更新日期:1993-07-01 00:00:00

  • An impact evaluation of the Safe Motherhood Program in China.

    abstract::Using 11 years of county-level panel data, fixed effect models are estimated to evaluate the impact of the Safe Motherhood (SM) Program in China. Propensity score matching is used to select comparable factual and counterfactual counties. Out of 2013 counties in China, 283 are selected for the treatment group and 1051 ...

    journal_title:Health economics

    pub_type: 杂志文章

    doi:10.1002/hec.1593

    authors: Feng XL,Shi G,Wang Y,Xu L,Luo H,Shen J,Yin H,Guo Y

    更新日期:2010-09-01 00:00:00