Abstract:
:Cost-effectiveness acceptability curves (CEACs) have become widely used in applied health technology assessment and at the same time are criticized as unreliable decision-making tool. In this paper we show how using CEACs differs from maximizing expected net benefit (NB) and when it can lead to inconsistent decisions. In the case of comparing two alternatives we show the limits of the discrepancy between CEAC and expected NB approach and link it with expected value of perfect information. We also show how the shape of CEAC is influenced by the skewness of estimate of expected NB distribution, the correlation between cost and effect estimates and their variance. In the case of more than two options we show when using CEACs can lead to non-transitive choices in pair-wise comparisons and when it lacks independence of irrelevant alternatives property in joint comparisons.
journal_name
Health Econjournal_title
Health economicsauthors
Jakubczyk M,Kamiński Bdoi
10.1002/hec.1534subject
Has Abstractpub_date
2010-08-01 00:00:00pages
955-63issue
8eissn
1057-9230issn
1099-1050journal_volume
19pub_type
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