Research decisions in the face of heterogeneity: what can a new study tell us?

Abstract:

:Willan and Eckermann describe a method for dealing with heterogeneity in value of information (VOI) calculations for prioritising and designing new research. Their article raises three fundamental (inter-related) issues for VOI methods: (1) how to make sense of the concept of uncertainty in a cost-effectiveness analysis (CEA) model, (2) the interpretation of heterogeneity in CEA, and (3) the relationship between data from a new study and the CEA model when there is heterogeneity. We discuss these three issues using an illustrative example meta-analysis of magnesium for myocardial infarction. Careful consideration of the relationship between existing (and future) evidence and the CEA model is required to provide practical VOI methods that can help research funders prioritise new research in the face of heterogeneity.

journal_name

Health Econ

journal_title

Health economics

authors

Welton N,Ades AE

doi

10.1002/hec.1797

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1196-200

issue

10

eissn

1057-9230

issn

1099-1050

journal_volume

21

pub_type

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