A double-blind controlled trial of 'Gaviscon' in patients with symptomatic gastro-oesophageal reflux.

abstract：BACKGROUND:In clinical practice, persistence with statin therapy is poor. While little is known about relative persistence to specific statins, previous studies have observed greater persistence in patients who achieve greater degrees of lipid lowering. Identification of statin therapies which improve patient persisten...

journal_title：Current medical research and opinion

authors： Foody JM,Joyce AT,Rudolph AE,Liu LZ,Benner JS

更新日期：2008-07-01 00:00:00

abstract：:A large, open, multi-centre study was carried out in general practice to evaluate the effectiveness and tolerance of a combination of 10 mg pindolol plus 5 mg clopamide, in single tablet form, in the treatment of patients with essential hypertension. Computer analysis of the records of 8989 patients who completed the ...

journal_title：Current medical research and opinion

authors： Crowder D,Cameron EG

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Elevated glucose blood levels are the key criteria for diagnosing diabetes mellitus (DM). Hyperglycaemia contributes to the pathophysiology associated with DM, including microvascular and possibly macrovascular disease. In spite of a wide range of pharmacological options available to reduce hyperglycaemia in...

journal_title：Current medical research and opinion

authors： Bays H

更新日期：2009-03-01 00:00:00

abstract：:A double-blind study was carried out to investigate the prophylactic use of single-dose cefuroxime in elective abdominal surgery. Twenty-three patients received 1.5 g cefuroxime by intravenous injection immediately prior to induction of anaesthesia; 24 patients received no antibiotics. In the cefuroxime group, there w...

journal_title：Current medical research and opinion

authors： Lambert WG,Mullinger BM

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:The primary objective of the study was to compare the percentage of men with mean serum total T (C(ave(0-24))) within normal range during the 24-h pharmacokinetic (PK) sampling period on Days 14 and 15. METHODS:Treatment with a new testosterone (T) buccal system, (Striant), 30 mg twice daily was compared to ...

journal_title：Current medical research and opinion

authors： Dobs AS,Matsumoto AM,Wang C,Kipnes MS

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Alternaria alternata (AA) sensitisation is a common cause of respiratory allergies such as rhinitis and asthma. So far there are no controlled double-blind trials evaluating the efficacy and safety of specific sublingual immunotherapy (SLIT) in AA allergies. OBJECTIVE:To evaluate the efficacy of SLIT treatm...

journal_title：Current medical research and opinion

authors： Pozzan M,Milani M

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To evaluate effectiveness and safety information of transdermal fentanyl (TDF) (Duragesic/Durogesic) and sustained-release oral morphine (SRM) in cancer pain (CP) and chronic non-cancer pain (NCP), a pooled analysis was conducted on datasets of published, open label, uncontrolled (no comparator group) and rando...

journal_title：Current medical research and opinion

authors： Clark AJ,Ahmedzai SH,Allan LG,Camacho F,Horbay GL,Richarz U,Simpson K

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To evaluate posaconazole pharmacokinetics in subjects with different degrees of hepatic impairment compared with matched healthy subjects. RESEARCH DESIGN AND METHODS:A total of 37 subjects were enrolled in this open-label, single-dose, parallel-group study; 19 with hepatic impairment and 18 healthy subjects...

journal_title：Current medical research and opinion

authors： Moton A,Krishna G,Ma L,O'Mara E,Prasad P,McLeod J,Preston RA

更新日期：2010-01-01 00:00:00

abstract：:Objectives: Atopic dermatitis (AD) is a chronic, relapsing skin condition, with signs and symptoms that impact patients' lives and are best measured from the patient perspective. Therefore, there is a need for AD-specific questionnaires that are consistent with Food and Drug Administration guidance and best measuremen...

journal_title：Current medical research and opinion

authors： Foley C,Tundia N,Simpson E,Teixeira HD,Litcher-Kelly L,Bodhani A

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:As an ever widening array of anti-hyperglycemic agents are now available, the effect of these drugs on lipids is increasingly complex and controversial. The present meta-analysis was designed to clarify the effect of a dual combination of noninsulin anti-hyperglycemic agents on lipids in type 2 diabetes. MET...

journal_title：Current medical research and opinion

authors： Dai X,Wang H,Jing Z,Fu P

更新日期：2014-09-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a major cause of morbidity and mortality and is associated with substantial healthcare costs. Identification of patients at risk of developing VTE enables appropriate thromboprophylaxis to be implemented. Although no predisposing risk factors can be identified in many patients in whom V...

journal_title：Current medical research and opinion

authors： Shirvanian S,Tapson VF

更新日期：2015-12-01 00:00:00

abstract：:Oesophageal mucosa has well established protective mechanisms, which operate within pre-epithelial, epithelial and post-epithelial compartments. Since refluxed acid and pepsin always act from the luminal side of the mucosa, protective factors like EGF, operating as a part of pre-epithelial defence, are thought to be p...

journal_title：Current medical research and opinion

authors： Marcinkiewicz M,Grabowska SZ,Czyzewska E

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:The objectives of this article are to review the pathophysiology of type 2 diabetes mellitus (T2DM), present the rationale for a pathophysiologically based treatment approach for patients with T2DM and discuss the role of the therapeutic combination of pioglitazone and exenatide in the management of T2DM. ME...

journal_title：Current medical research and opinion

authors： Schwartz S

更新日期：2008-11-01 00:00:00

abstract：: Background & aims: Vitamin D deficiency is widespread worldwide. In this study, we aimed to evaluate the effect of a nano encapsulated form of vitamin D used for fortifying low-fat dairy products (milk and yogurt) on anthropometric indices, glycemic status, and lipid profi...

journal_title：Current medical research and opinion

authors： Sharifan P,Ziaee A,Darroudi S,Rezaie M,Safarian M,Eslami S,Khadem-Rezaiyan M,Tayefi M,Mohammadi M,Ghazizadeh H,Khorasanchi Z,Bagherniya M,Sardar MA,Ferns G,Vatanparast H,Ghayour Mobarhan M

更新日期：2021-01-12 00:00:00

abstract：:A study was carried out to determine the efficacy and long-term safety of dantrolene in treating stroke patients with spasticity limiting rehabilitation. Fifteen of the 18 patients studied experienced reduction in spasticity and clinical improvement after treatment with dantrolene sodium for 6 weeks. Fourteen of these...

journal_title：Current medical research and opinion

authors： Ketel WB,Kolb ME

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:Clinical evidence supports the use of cardiac resynchronization therapy (CRT) in advanced heart failure, but its cost-effectiveness is still unclear. This analysis assessed the economic and health consequences in the UK of implanting a CRT in patients with NYHA class III-IV heart failure. METHODS:A discrete ...

journal_title：Current medical research and opinion

authors： Caro JJ,Guo S,Ward A,Chalil S,Malik F,Leyva F

更新日期：2006-06-01 00:00:00

abstract：:Objective To assess the efficacy of a mixed intervention, educational, and reminder calendar of the intake, as a strategy to improve therapeutic adherence with dabigatran in patients with non-valvular atrial fibrillation (NVAF). Methods This was a prospective, longitudinal, multi-center study, carried out in 110 speci...

journal_title：Current medical research and opinion

authors： Márquez-Contreras E,Martell-Claros N,Márquez-Rivero S,Hermida-Campa E,Gracia-Diez C,Sanchez-López E,Gil-Guillén V,Compliance and Inertia Working Group, Spanish Society of Hypertension (SEH-LELHA).

更新日期：2018-07-01 00:00:00

abstract：:Twenty patients with mild to moderate hypertension participated in a single-blind crossover comparison of treatment with 25 mg hydrochlorothiazide plus 50 mg triamterene and 50 mg hydrochlorothiazide plus 5 mg amiloride in once-daily dosage regimens. After a 2-week run-in period without treatment, patients were alloca...

journal_title：Current medical research and opinion

authors： Dean S,Spencer-Mills L

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVES:Health economic analysis from a healthcare and societal point of view was conducted to assess the cost-effectiveness of insulin degludec (IDeg) after switching from other basal insulins in people with type 1 diabetes. MATERIAL AND METHODS:This was a prospective, open-label, single arm, observational follow-...

journal_title：Current medical research and opinion

authors： Landstedt-Hallin L,Gundgaard J,Ericsson Å,Ellfors-Zetterlund S

更新日期：2017-04-01 00:00:00

abstract：:Data from phase III clinical trials suggest that high dose chemotherapy (HDC) is currently not indicated for any stage of breast cancer. Therefore HDC should only be considered within the context of clinical trials. Furthermore, there is no significant evidence to support the routine use of taxanes in women with metas...

journal_title：Current medical research and opinion

authors： Mokbel K,Elkak A

更新日期：2001-01-01 00:00:00

abstract：:A double-blind trial was carried out in 45 anxious out-patients to compare the effectiveness and tolerance of clobazam and diazepam. The severity of each patient's symptoms was assessed before, during and at the end of the trial period using the Hamilton Anxiety Rating Scale, and a note kept of any side-effects. The r...

journal_title：Current medical research and opinion

authors： Botter PA

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVES:Epidemiological data support an association between age-related macular degeneration (AMD) and cataract surgery that may be attributed to post-operative blue light exposure. By limiting the retina's blue light exposure, new blue-light filtering intraocular lenses (BLF IOLs) have the potential to reduce the d...

journal_title：Current medical research and opinion

authors： Reddy P,Gao X,Barnes R,Fairchild C,Boci K,Waycaster C,Pashos C

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:Neurogenic bladder refers to morphofunctional alterations of the bladder-sphincter complex secondary to central or peripheral neurological lesions. Discal etiology can be suggested by clinical observation in patients complaining of classical lower back pain, but not excluded even without musculoskeletal pain....

journal_title：Current medical research and opinion

authors： Siracusa G,Sparacino A,Lentini VL

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Many children with severe persistent allergic (IgE-mediated) asthma remain inadequately controlled despite treatment with high-dose inhaled corticosteroids (ICS) plus a long-acting beta(2)-agonist (LABA). RESEARCH AND DESIGN METHODS:This pre-specified analysis of a randomized, double-blind, placebo-controll...

journal_title：Current medical research and opinion

authors： Kulus M,Hébert J,Garcia E,Fowler Taylor A,Fernandez Vidaurre C,Blogg M

更新日期：2010-06-01 00:00:00

abstract：:Control of hypertension is hindered by the incidence of adverse events associated with therapy, which can result in low patient compliance. Specific angiotensin II receptor subtype AT1 blockers offer an alternative to the angiotensin converting enzyme inhibitors in the treatment of hypertension, as the incidence of si...

journal_title：Current medical research and opinion

authors： Levine B

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:It has been postulated that intraocular pressure, an important glaucoma risk factor, correlates positively with arterial blood pressure (blood pressure). However, results of experimental and clinical studies are often contradictory. It is hypothesized that, in some hypertensive patients, disturbances in intr...

journal_title：Current medical research and opinion

authors： Skrzypecki J,Grabska-Liberek I,Przybek J,Ufnal M

更新日期：2018-03-01 00:00:00

abstract：:A multi-centre, double-blind trial was carried out in general practice in 44 patients with symptoms of neurotic anxiety to compare the effects of treatment with either 400 mg chlormezanone at night or 5 mg diazepam 3-times daily for 4 weeks. The results indicated tht there were similar improvements in anxiety, duratio...

journal_title：Current medical research and opinion

authors： Allin DM

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to analyze the characteristics and costs of exogenous endoscopy-related infections, pseudo-infections, and toxic reactions in the US. METHODS:A systematic review of the scientific literature published between 1966 and 2005 was conducted in Medline. Data collection was based o...

journal_title：Current medical research and opinion

authors： Seoane-Vazquez E,Rodriguez-Monguio R,Visaria J,Carlson A

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:Previous systematic reviews and meta-analyses of treatments in relapsing-remitting multiple sclerosis (RRMS) derived their findings from either placebo-controlled studies only or separately from head-to-head and comparative studies. The purpose of this study is to compare annualized relapse rates (ARR) of fi...

journal_title：Current medical research and opinion

authors： Roskell NS,Zimovetz EA,Rycroft CE,Eckert BJ,Tyas DA

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:To determine the characteristics of asthma (A) and allergic rhinitis (AR) among asthma patients in primary care practice. RESEARCH DESIGN AND METHODS:Primary care physicians, pulmonologists, and allergologists were asked to recruit consecutive asthma patients with or without allergic rhinitis from their dail...

journal_title：Current medical research and opinion

authors： Taegtmeyer AB,Steurer-Stey C,Spertini F,Bircher A,Helbling A,Miedinger D,Schafroth S,Scherer K,Leuppi JD

更新日期：2009-05-01 00:00:00