当前位置： SCI文献检索 > RESUSCITATION期刊下所有文献 > Effects of epinephrine in a pig model of hypothermic cardiac arrest and closed-chest cardiopulmonary resuscitation combined with active rewarming.

Effects of epinephrine in a pig model of hypothermic cardiac arrest and closed-chest cardiopulmonary resuscitation combined with active rewarming.

Abstract：

OBJECTIVE:The aim of the current study was to assess the effects of epinephrine in a pig model of hypothermic cardiac arrest followed by closed-chest cardiopulmonary resuscitation combined with active rewarming, simulating the clinical management of an arrested hypothermic patient in a hospital without cardiopulmonary bypass facilities. DESIGN:Prospective, randomized animal study. SETTING:University research laboratory. SUBJECTS:Twelve 12- to 16-week-old domestic pigs. INTERVENTIONS:Pigs were surface cooled to a body core temperature of 28 degrees C. After 4 min of untreated cardiac arrest, manual closed-chest CPR and thoracic lavage with 40 degrees C warmed fluid were started. After 3 min of external chest compression animals were randomly assigned to receive epinephrine (45, 45 and 200 microg/kg) or saline placebo in 5-min intervals. MEASUREMENTS AND MAIN RESULTS:Coronary perfusion pressure was about 15 mmHg in placebo group pigs. Coronary perfusion pressure was significantly higher after epinephrine, but restoration of spontaneous circulation was not more frequent (one of six epinephrine versus three of six saline placebo pigs, P=0.34). After 45 microg/kg epinephrine the arterial PO(2) was significantly lower when compared to the saline placebo. The third 200 microg/kg epinephrine dose resulted in a significantly enhanced mixed venous hypercarbic acidosis. CONCLUSIONS:After a short 4-min period of hypothermic cardiac arrest, epinephrine may not be necessary to maintain coronary perfusion pressure around the threshold usually correlating with successful defibrillation, even during prolonged closed-chest CPR combined with active rewarming. The enhanced mixed venous hypercarbic acidosis in epinephrine-treated animals may support the argument against repeated or high dose epinephrine administration during hypothermic CPR.

journal_name

Resuscitation

journal_title

Resuscitation

authors

Kornberger E,Lindner KH,Mayr VD,Schwarz B,Rackwitz KS,Wenzel V,Krismer AC,Mair P

doi

10.1016/s0300-9572(01)00353-7

keywords:

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

301-8

issue

3

eissn

0300-9572

issn

1873-1570

pii

S0300957201003537

journal_volume

50

pub_type

杂志文章

相关文献

RESUSCITATION文献大全
  • New conventional long-term survival normovolemic cardiac arrest pig model.

    abstract：AIM OF THE STUDY:A reproducible long-term intensive care and outcome cardiac arrest model for exploring new cerebral preservation strategies is needed. We tried to determine effects and limitations of current therapies after different 'no-flow' times. METHODS:Thirty-five female Large White Breed pigs (26-37kg) were in...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2010.08.040

    authors： Schratter A,Holzer M,Sterz F,Janata A,Sipos W,Uray T,Losert U,Behringer W

    更新日期：2011-01-01 00:00:00

  • A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation.

    abstract：OBJECTIVE:To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation. METHODS:A muscle crush injury and 40% estimated blood volume controlled hemorrhage was completed in 24 Yucatan mini-pigs. Pigs were untreated or resuscitated w...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2005.03.019

    authors： Philbin N,Rice J,Gurney J,McGwin G,Arnaud F,Dong F,Johnson T,Flournoy WS,Ahlers S,Pearce LB,McCarron R,Freilich D

    更新日期：2005-09-01 00:00:00

  • Low rates of immediate coronary angiography among young adults resuscitated from sudden cardiac arrest.

    abstract：AIM:Coronary artery disease (CAD) has recently been emphasized as a major cause of sudden cardiac arrest (SCA) in young adults. We aim to assess the rate of immediate coronary angiography performance in young patients resuscitated from SCA. METHODS:From May 2011 to May 2017, all cases of out-of-hospital SCA aged 18-40...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2019.12.005

    authors： Waldmann V,Karam N,Rischard J,Bougouin W,Sharifzadehgan A,Dumas F,Narayanan K,Sideris G,Voicu S,Gandjbakhch E,Jost D,Lamhaut L,Ludes B,Plu I,Beganton F,Wahbi K,Varenne O,Megarbane B,Algalarrondo V,Extramiana F,Lel

    更新日期：2020-02-01 00:00:00

  • Comparing three CPR feedback devices and standard BLS in a single rescuer scenario: a randomised simulation study.

    abstract：BACKGROUND:Efficiently performed basic life support (BLS) after cardiac arrest is proven to be effective. However, cardiopulmonary resuscitation (CPR) is strenuous and rescuers' performance declines rapidly over time. Audio-visual feedback devices reporting CPR quality may prevent this decline. We aimed to investigate ...

    journal_title：Resuscitation

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.resuscitation.2013.10.028

    authors： Zapletal B,Greif R,Stumpf D,Nierscher FJ,Frantal S,Haugk M,Ruetzler K,Schlimp C,Fischer H

    更新日期：2014-04-01 00:00:00

  • Comparison of GlideScope(®) versus Macintosh laryngoscope for the removal of a hypopharyngeal foreign body: a randomized cross-over cadaver study.

    abstract：OBJECTIVE:This study aimed to evaluate whether GlideScope(®) is an effective and acceptable method for the removal of a hypopharyngeal foreign body. METHODS:This was a prospective study conducted in 28 first year emergency residents with little prior airway management experience. Participants extracted hypopharyngeal ...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2012.02.032

    authors： Je SM,Kim MJ,Chung SP,Chung HS

    更新日期：2012-10-01 00:00:00

  • Plasma lidocaine levels occurring with endotracheal administration during hemorrhagic shock.

    abstract：:During the many emergency situations in which venous access is difficult or impossible, endotracheal drug administration is an effective alternative means of delivering life-saving medications. Shock is a commonly encountered emergency situation in which endotracheal drug therapy can and is often used. Yet whether a d...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/0300-9572(90)90108-q

    authors： Mace SE

    更新日期：1990-06-01 00:00:00

  • Chest compression-only versus conventional cardiopulmonary resuscitation for bystander-witnessed out-of-hospital cardiac arrest of medical origin: A propensity score-matched cohort from 143,500 patients.

    abstract：BACKGROUND:Current cardiopulmonary resuscitation (CPR) guidelines do not define the optimal type of CPR (chest compression-only CPR [CCCPR] or conventional CPR with rescue breathing [CCRB]) to be performed by bystanders when they witness someone collapse. METHODS:Using a nationwide database of 1.17 million patients wh...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2018.02.017

    authors： Kitamura T,Kiyohara K,Nishiyama C,Kiguchi T,Kobayashi D,Kawamura T,Iwami T

    更新日期：2018-05-01 00:00:00

  • Development of a strategic process using checklists to facilitate team preparation and improve communication during neonatal resuscitation.

    abstract：BACKGROUND:To improve our neonatal resuscitations we review video recordings of actual high-risk deliveries as an ongoing quality review process. In order to help identify and review errors that occurred during resuscitation we educated our resuscitation teams using crew resource management and in March 2009 developed ...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2013.06.012

    authors： Katheria A,Rich W,Finer N

    更新日期：2013-11-01 00:00:00

  • Resuscitation of out-of-hospital cardiac arrest by Asian primary health-care physicians.

    abstract：AIM:To assess the experience, knowledge and attitudes of local primary health-care doctors towards resuscitation in out-of-hospital cardiac arrest. METHODS:We conducted a survey of general practitioners (GPs) working in both private and public sectors. The survey consisted of 29 questions and was self-administered. R...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2004.11.021

    authors： Ong ME,Chan YH,Ang HY,Lim SH,Tan KL

    更新日期：2005-05-01 00:00:00

  • Life after cardiac arrest; a retrospective study.

    abstract：AIM:We decided to evaluate the life situation of the survivors after out-of-hospital cardiopulmonary resuscitation (CPR). METHOD:CPR survivors who were 75 years or younger at the time and who were discharged alive from the hospital were identified consecutively. Average follow-up time was 25.5 months, and at follow-up...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/0300-9572(95)00903-5

    authors： Sunnerhagen KS,Johansson O,Herlitz J,Grimby G

    更新日期：1996-04-01 00:00:00

  • Decrease in the occurrence of ventricular fibrillation as the initially observed arrhythmia after out-of-hospital cardiac arrest during 11 years in Sweden.

    abstract：AIM:To describe the change in the occurrence of ventricular fibrillation as initially observed arrhythmia among patients suffering from out-of-hospital cardiac arrest in Sweden. PATIENTS:All patients included in the Swedish cardiac arrest registry between 1991 until 2001. The registry covers 85% of the population in S...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2003.11.003

    authors： Herlitz J,Engdahl J,Svensson L,Young M,Angquist KA,Holmberg S

    更新日期：2004-03-01 00:00:00

  • Comparison of two emergency response systems and their effect on survival from out of hospital cardiac arrest.

    abstract：:The pre-hospital care provided by emergency response systems will have an effect on the outcome of patients who have sustained an out of hospital cardiac arrest. This study compares the results of resuscitation in two centres, one in the UK (Edinburgh) and the other in the USA (Milwaukee), and examines the demographic...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/s0300-9572(97)00072-5

    authors： Mitchell RG,Brady W,Guly UM,Pirrallo RG,Robertson CE

    更新日期：1997-11-01 00:00:00

  • Future directions for resuscitation research. V. Ultra-advanced life support.

    abstract：:Standard external cardiopulmonary resuscitation (SECPR) frequently produces very low perfusion pressures, which are inadequate to achieve restoration of spontaneous circulation (ROSC) and intact survival, particularly when the heart is diseased. Ultra-advanced life support (UALS) techniques may allow support of vital ...

    journal_title：Resuscitation

    pub_type： 杂志文章,评审

    doi：10.1016/s0300-9572(96)01065-9

    authors： Tisherman SA,Vandevelde K,Safar P,Morioka T,Obrist W,Corne L,Buckman RF,Rubertsson S,Stephenson HE,Grenvik A,White RJ

    更新日期：1997-06-01 00:00:00

  • First aid cooling techniques for heat stroke and exertional hyperthermia: A systematic review and meta-analysis.

    abstract：BACKGROUND:Heat stroke is an emergent condition characterized by hyperthermia (>40 °C/>104 °F) and nervous system dysregulation. There are two primary etiologies: exertional which occurs during physical activity and non-exertional which occurs during extreme heat events without physical exertion. Left untreated, both m...

    journal_title：Resuscitation

    pub_type： 杂志文章,评审

    doi：10.1016/j.resuscitation.2020.01.007

    authors： Douma MJ,Aves T,Allan KS,Bendall JC,Berry DC,Chang WT,Epstein J,Hood N,Singletary EM,Zideman D,Lin S,First Aid Task Force of the International Liaison Committee on Resuscitation.

    更新日期：2020-03-01 00:00:00

  • Amiodarone or nifekalant upon hospital arrival for refractory ventricular fibrillation after out-of-hospital cardiac arrest.

    abstract：BACKGROUND:We evaluated the association between nifekalant or amiodarone on hospital admission and in-hospital mortality for cardiac arrest patients with persistent ventricular fibrillation on hospital arrival. METHODS:This was a retrospective cohort study using the Japanese Diagnosis Procedure Combination inpatient d...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2016.08.017

    authors： Tagami T,Matsui H,Ishinokami S,Oyanagi M,Kitahashi A,Fukuda R,Unemoto K,Fushimi K,Yasunaga H

    更新日期：2016-12-01 00:00:00

  • Assessment of free radical-induced damage in brain proteins after ischemia and reperfusion.

    abstract：:Brain damage initiated during global ischemia has been shown to be exacerbated by iron-dependent lipid peroxidation during early reperfusion. We hypothesized that other cellular components might be involved in similar free radical reactions. In this study we examined three brain protein fractions and ribosomal RNA for...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/0300-9572(92)90162-6

    authors： Krause GS,DeGracia DJ,Skjaerlund JM,O'Neil BJ

    更新日期：1992-02-01 00:00:00

  • The effect of cytidine diphosphate choline on in vivo lung mechanics in premature newborn rabbits.

    abstract：:The influence of CDP-choline on neonatal lung adaptation was studied in premature rabbit neonates, delivered on day 28 of gestation. We found that the administration of CDP-choline (200 mg/kg body wt) at birth has a moderately beneficial effect on the respiratory frequency, dynamic lung compliance, and expiratory lung...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/0300-9572(80)90005-2

    authors： Lachmann B,Grossmann G,Malmqvist E,Nilsson R,Robertson B

    更新日期：1980-03-01 00:00:00

  • Detection of a spontaneous pulse in photoplethysmograms during automated cardiopulmonary resuscitation in a porcine model.

    abstract：INTRODUCTION:Reliable, non-invasive detection of return of spontaneous circulation (ROSC) with minimal interruptions to chest compressions would be valuable for high-quality cardiopulmonary resuscitation (CPR). We investigated the potential of photoplethysmography (PPG) to detect the presence of a spontaneous pulse dur...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2013.07.019

    authors： Wijshoff RW,van der Sar T,Peeters WH,Bezemer R,Aelen P,Paulussen IW,Ordelman SC,Venema A,van Berkom PF,Aarts RM,Woerlee PH,Scheffer GJ,Noordergraaf GJ

    更新日期：2013-11-01 00:00:00

  • Drowning: a review of epidemiology, pathophysiology, treatment and prevention.

    abstract：:Although often preventable, drowning remains a leading cause of accidental death, especially in children. New definitions classify drowning as the process of experiencing respiratory impairment from submersion or immersion in a liquid. The key pathophysiological feature in drowning is hypoxia. Accurate neurological pr...

    journal_title：Resuscitation

    pub_type： 杂志文章,评审

    doi：10.1016/j.resuscitation.2004.06.007

    authors： Salomez F,Vincent JL

    更新日期：2004-12-01 00:00:00

  • The influence of tracheal vascularization on the optimum location, shape and size of the tracheostomy in prolonged intubation.

    abstract：:Tracheal complications due to prolonged intensive therapy were studied. By means of angiography and dye injection of blood vessels in human cadavers, and by means of surgery in dogs, the arterial systems of the trachea in both species have been analysed with regard to problems arising during prolonged intubation in th...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/0300-9572(78)90020-5

    authors： Bercic J,Pocajt M,Drzecnik J

    更新日期：1978-01-01 00:00:00

  • Cardiac complications in preterm infants with percutaneous long lines: the importance of early diagnosis.

    abstract：:Percutaneous long lines, routinely used in preterm infants, can be associated with several cardiac complications such as pericardial effusion and consequent cardiac tamponade. We report three patients with pericardial effusion highlighting the importance of cardiac ultrasound monitoring to both early diagnosis and tre...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2008.07.023

    authors： Fusco FP,De Carolis MP,Costa S,De Rosa G,Zambraro A,Romagnoli C

    更新日期：2008-12-01 00:00:00

  • Trends in the incidence of presumed cardiac out-of-hospital cardiac arrest in Perth, Western Australia, 1997-2010.

    abstract：AIM:This study investigated temporal trends in the incidence of out-of-hospital cardiac arrests (OHCA) in metropolitan Perth (Western Australia) between 1997 and 2010. METHODS:We calculated crude and age-and-sex-standardised incidence rates (ASIRs) using the 2011 Australian population as the standard population. Incid...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2014.02.017

    authors： Bray JE,Di Palma S,Jacobs I,Straney L,Finn J

    更新日期：2014-06-01 00:00:00

  • Incidence of re-arrest and critical events during prolonged transport of post-cardiac arrest patients.

    abstract：AIM:To determine the feasibility of transporting post-cardiac arrest patients to tertiary-care facilities, the rate of re-arrest, and the rate of critical events during critical care transport team (CCTT) care. METHODS:Retrospective chart review of cardiac arrest patients transported via CCTT between 1/1/2001 and 5/31...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2010.04.012

    authors： Hartke A,Mumma BE,Rittenberger JC,Callaway CW,Guyette FX

    更新日期：2010-08-01 00:00:00

  • Beta-blocker use and the changing epidemiology of out-of-hospital cardiac arrest rhythms.

    abstract：BACKGROUND:The incidence of ventricular fibrillation (VF) as the presenting rhythm in out-of-hospital cardiac arrest (OHCA) is declining, whereas pulseless electrical activity (PEA) is increasing. This changing epidemiology has occurred concomitant with an increase in beta-blocker use. AIMS:The aim of this study was t...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2007.08.022

    authors： Youngquist ST,Kaji AH,Niemann JT

    更新日期：2008-03-01 00:00:00

  • Incidence and outcome from adult cardiac arrest occurring in the intensive care unit: a systematic review of the literature.

    abstract：BACKGROUND:Significant amount of data on the incidence and outcome of out-of-hospital and in-hospital cardiac arrest have been published. Cardiac arrest occurring in the intensive care unit has received less attention. AIMS:To evaluate and summarize current knowledge of intensive care unit cardiac arrest including qua...

    journal_title：Resuscitation

    pub_type： 杂志文章,评审

    doi：10.1016/j.resuscitation.2013.12.027

    authors： Efendijev I,Nurmi J,Castrén M,Skrifvars MB

    更新日期：2014-04-01 00:00:00

  • Standardising communication to improve in-hospital cardiopulmonary resuscitation.

    abstract：AIM:Recommendations for standardised communication to reduce chest compression (CC) pauses are lacking. We aimed to achieve consensus and evaluate feasibility and efficacy using standardised communication during cardiopulmonary resuscitation (CPR) events. METHODS:Modified Delphi consensus process to design standardise...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2019.12.013

    authors： Lauridsen KG,Watanabe I,Løfgren B,Cheng A,Duval-Arnould J,Hunt EA,Good GL,Niles D,Berg RA,Nishisaki A,Nadkarni VM

    更新日期：2020-02-01 00:00:00

  • Vasopressin and epinephrine are equally effective for CPR in a rat asphyxia model.

    abstract：:Epinephrine has been administered as a drug essential for cardiopulmonary resuscitation (CPR). Recently, vasopressin has been reported to be more effective than epinephrine for CPR in a ventricular fibrillation (VF) model. As a different myocardial pathology is speculated to exist between the VF model and the asphyxia...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/s0300-9572(01)00447-6

    authors： Kono S,Bito H,Suzuki A,Obata Y,Igarashi H,Sato S

    更新日期：2002-02-01 00:00:00

  • Hemodynamic monitoring in the operating room.

    abstract：:Cardiopulmonary homeostasis for the high risk surgical patient is dependent on invasive monitoring techniques which are designed to allow for the early detection of physiological dysfunction during the development stages. One must maintain both minimum and maximum predetermined cardiorespiratory values by the early ut...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/0300-9572(84)90014-5

    authors： de Angelis J

    更新日期：1984-03-01 00:00:00

  • Baby-directed umbilical cord clamping: A feasibility study.

    abstract：INTRODUCTION:Over five percent of infants born worldwide will need help breathing after birth. Delayed cord clamping (DCC) has become the standard of care for vigorous infants. DCC in non-vigorous infants is uncommon because of logistical difficulties in providing effective resuscitation during DCC. In Baby-Directed Um...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2018.07.020

    authors： Blank DA,Badurdeen S,Omar F Kamlin C,Jacobs SE,Thio M,Dawson JA,Kane SC,Dennis AT,Polglase GR,Hooper SB,Davis PG

    更新日期：2018-10-01 00:00:00

  • Emergency medical service transport-induced stress? An experimental approach with healthy volunteers.

    abstract：:This randomized controlled trial was designed to evaluate the effects of simulated emergency medical service (EMS) transport related stress on hemodynamic variables, and catecholamine plasma levels. A total of 32 healthy male volunteers were randomized to being carried by paramedics from a third-floor apartment throug...

    journal_title：Resuscitation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0300-9572(00)00354-3

    authors： Dörges V,Wenzel V,Kühl A,Dix S,Hüppe M,Gehring H,Schumann T,Gerlach K

    更新日期：2001-05-01 00:00:00