Pharmacokinetic interactions between cyclosporine and bupropion or methylphenidate.

Abstract:

:A 10-year-old boy with a history of heart transplantation had a potentially life-threatening decrease in his cyclosporine (CSA) blood levels during administration of bupropion. Subsequently he had an increase in CSA levels while receiving methylphenidate. These occurrences represent potential drug-drug interactions in children not previously documented in the literature. The CSA-bupropion and CSA-methylphenidate interactions merit further investigation, particularly because psychotropic agents are often prescribed in combination with immunosuppressants in transplantation patients of all ages.

authors

Lewis BR,Aoun SL,Bernstein GA,Crow SJ

doi

10.1089/104454601750284117

keywords:

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

193-8

issue

2

eissn

1044-5463

issn

1557-8992

journal_volume

11

pub_type

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