Abstract:
:For a few decades, patients with Parkinson's disease (PD) have been treated with intracerebral transplantations of fetal mesencephalic tissue. The results of open trials have been variable. Double blind, placebo-controlled studies have recently been started in order to further investigate the efficacy of this new medical technique. In this paper we challenge the need for sham surgery in neurotransplantation research on PD patients. Considerations regarding the research subjects' informed consent, therapeutic misconception, the integrity of the human body, and the assessment of risks and benefits argue against sham surgery for patients with PD. Moreover, there is an alternative, less harmful mode of research that can provide the same or comparable scientific evidence. A plea is made for intrapatient research based on quantitative measurements of the patient's pre- and post-operative condition combined with similar research on a reference group of patients who have received the standard treatment.
journal_name
J Med Ethicsjournal_title
Journal of medical ethicsauthors
Dekkers W,Boer Gdoi
10.1136/jme.27.3.151keywords:
subject
Has Abstractpub_date
2001-06-01 00:00:00pages
151-6issue
3eissn
0306-6800issn
1473-4257journal_volume
27pub_type
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pub_type: 评论,杂志文章
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更新日期:2019-03-01 00:00:00
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doi:10.1136/jme.2008.027615
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journal_title:Journal of medical ethics
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doi:10.1136/medethics-2011-100136
更新日期:2012-04-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 传,历史文章,杂志文章
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更新日期:2012-07-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:
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journal_title:Journal of medical ethics
pub_type: 历史文章,杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2020-106493
更新日期:2021-01-05 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.2006.016477
更新日期:2007-01-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2020-106177
更新日期:2020-07-06 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.11.1.35
更新日期:1985-03-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2012-100715
更新日期:2014-05-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2020-106294
更新日期:2020-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/medethics-2015-103189
更新日期:2017-09-01 00:00:00